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Protein

Basic phospholipase A2 VRV-PL-VIIIa

Gene
N/A
Organism
Daboia russelii (Russel's viper) (Vipera russelii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC50 is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.3 Publications

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi29Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi31Calcium; via carbonyl oxygenCombined sources1 Publication1
Active sitei47By similarity1
Metal bindingi48CalciumCombined sources1 Publication1
Active sitei89By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionBlood coagulation cascade inhibiting toxin, Hemostasis impairing toxin, Hydrolase, Myotoxin, Neurotoxin, Presynaptic neurotoxin, Toxin
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.4 5485

Names & Taxonomyi

Protein namesi
Recommended name:
Basic phospholipase A2 VRV-PL-VIIIa (EC:3.1.1.4)
Short name:
svPLA2
Alternative name(s):
DPLA2
P1
Phosphatidylcholine 2-acylhydrolase
Phospholipase A2 4
Short name:
PLA24
OrganismiDaboia russelii (Russel's viper) (Vipera russelii)
Taxonomic identifieri8707 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeDaboia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is between 5.3 and 5.5 mg/kg by intravenous injection into mice.2 Publications

Chemistry databases

ChEMBLiCHEMBL3784910

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001617171 – 121Basic phospholipase A2 VRV-PL-VIIIaAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 115Combined sources3 Publications
Disulfide bondi28 ↔ 44Combined sources3 Publications
Disulfide bondi43 ↔ 95Combined sources3 Publications
Disulfide bondi49 ↔ 121Combined sources3 Publications
Disulfide bondi50 ↔ 88Combined sources3 Publications
Disulfide bondi57 ↔ 81Combined sources3 Publications
Disulfide bondi75 ↔ 86Combined sources3 Publications

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP59071

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

1121
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP59071
SMRiP59071
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP59071

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008137

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

P59071-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SLLEFGKMIL EETGKLAIPS YSSYGCYCGW GGKGTPKDAT DRCCFVHDCC
60 70 80 90 100
YGNLPDCNPK SDRYKYKRVN GAIVCEKGTS CENRICECDK AAAICFRQNL
110 120
NTYSKKYMLY PDFLCKGELK C
Length:121
Mass (Da):13,611
Last modified:November 1, 2002 - v1
Checksum:i5CDF82DDA7DA638E
GO

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CL5X-ray2.45A/B1-121[»]
1FB2X-ray1.95A/B1-121[»]
1FV0X-ray1.70A/B1-121[»]
1JQ8X-ray2.00A/B1-121[»]
1JQ9X-ray1.80A/B1-121[»]
1KPMX-ray1.80A/B1-121[»]
1OXLX-ray1.80A/B1-121[»]
1OYFX-ray2.45A1-121[»]
1SKGX-ray1.21A1-121[»]
1SQZX-ray1.20A1-121[»]
1SV3X-ray1.35A1-121[»]
1SV9X-ray2.71A1-121[»]
1SXKX-ray1.21A1-121[»]
1TDVX-ray1.70A1-121[»]
1TG1X-ray1.25A1-121[»]
1TG4X-ray1.70A1-121[»]
1TGMX-ray1.86A1-121[»]
1TH6X-ray1.23A1-121[»]
1TJ9X-ray1.10A1-121[»]
1TJKX-ray1.25A1-121[»]
1TK4X-ray1.10A1-121[»]
1TP2X-ray2.40A/B1-121[»]
1Y38X-ray2.44A/B1-121[»]
1ZR8X-ray2.03A1-121[»]
1ZWPX-ray1.10A1-121[»]
1ZYXX-ray1.95A1-121[»]
2B17X-ray2.71A1-121[»]
2DO2X-ray2.60A1-121[»]
2DPZX-ray2.10A1-121[»]
2FNXX-ray2.70A1-121[»]
2G58X-ray0.98A1-121[»]
2GNSX-ray2.30A1-121[»]
2O1NX-ray2.80A1-121[»]
2OLIX-ray2.21A1-121[»]
2OTFX-ray1.95A1-121[»]
2OTHX-ray2.90A1-121[»]
2OUBX-ray2.75A1-121[»]
2OYFX-ray1.20A1-121[»]
2PB8X-ray2.00A1-121[»]
2PMJX-ray2.40A1-121[»]
2PVTX-ray2.10A1-121[»]
2PWSX-ray2.21A1-121[»]
2PYCX-ray1.50A1-121[»]
2Q1PX-ray1.50A1-121[»]
2QHWX-ray2.21A1-121[»]
2QU9X-ray2.08A1-121[»]
2QUEX-ray2.25A1-121[»]
2QVDX-ray1.93A1-121[»]
2ZBHX-ray2.60A1-121[»]
3CBIX-ray3.15A/B/C/D1-121[»]
3G8FX-ray1.25A1-121[»]
3H1XX-ray1.40A1-121[»]
ProteinModelPortaliP59071
SMRiP59071
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL3784910

Proteomic databases

PRIDEiP59071

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008137

Enzyme and pathway databases

BRENDAi3.1.1.4 5485

Miscellaneous databases

EvolutionaryTraceiP59071

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPA2B8_DABRR
AccessioniPrimary (citable) accession number: P59071
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: July 18, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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