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Entry version 151 (08 May 2019)
Sequence version 2 (25 Nov 2008)
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Protein

NACHT, LRR and PYD domains-containing protein 5

Gene

NLRP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi286 – 293ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 5
Alternative name(s):
Mater protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NLRP5
Synonyms:MATER, NALP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21269 NLRP5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609658 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P59047

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
126206

Open Targets

More...
OpenTargetsi
ENSG00000171487

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162397970

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NLRP5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274029

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000808901 – 1200NACHT, LRR and PYD domains-containing protein 5Add BLAST1200

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P59047

PeptideAtlas

More...
PeptideAtlasi
P59047

PRoteomics IDEntifications database

More...
PRIDEi
P59047

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57122

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P59047

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P59047

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Oocyte-specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171487 Expressed in 17 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P59047 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P59047 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056271

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SCMC which also includes at least OOEP and TLE6.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125965, 10 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P59047

Protein interaction database and analysis system

More...
IntActi
P59047, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375063

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P59047

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 148PyrinPROSITE-ProRule annotationAdd BLAST92
Domaini280 – 602NACHTPROSITE-ProRule annotationAdd BLAST323
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati704 – 727LRR 1Add BLAST24
Repeati730 – 753LRR 2Add BLAST24
Repeati780 – 803LRR 3Add BLAST24
Repeati809 – 832LRR 4Add BLAST24
Repeati836 – 863LRR 5Add BLAST28
Repeati865 – 892LRR 6Add BLAST28
Repeati893 – 916LRR 7Add BLAST24
Repeati950 – 973LRR 8Add BLAST24
Repeati979 – 1002LRR 9Add BLAST24
Repeati1007 – 1034LRR 10Add BLAST28
Repeati1036 – 1059LRR 11Add BLAST24
Repeati1064 – 1092LRR 12Add BLAST29
Repeati1121 – 1142LRR 13Add BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIY8 Eukaryota
ENOG4111BJJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162898

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294064

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P59047

KEGG Orthology (KO)

More...
KOi
K22626

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSFQEVW

Database of Orthologous Groups

More...
OrthoDBi
114368at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P59047

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR041267 NLRC_HD2
IPR041075 NOD2_WH
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516 LRR_6, 5 hits
PF05729 NACHT, 1 hit
PF17776 NLRC4_HD2, 1 hit
PF17779 NOD2_WH, 1 hit
PF02758 PYRIN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01289 PYRIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50824 DAPIN, 1 hit
PS50837 NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P59047-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVAGGLELG AAALLSASPR ALVTLSTGPT CSILPKNPLF PQNLSSQPCI
60 70 80 90 100
KMEGDKSLTF SSYGLQWCLY ELDKEEFQTF KELLKKKSSE STTCSIPQFE
110 120 130 140 150
IENANVECLA LLLHEYYGAS LAWATSISIF ENMNLRTLSE KARDDMKRHS
160 170 180 190 200
PEDPEATMTD QGPSKEKVPG ISQAVQQDSA TAAETKEQEI SQAMEQEGAT
210 220 230 240 250
AAETEEQEIS QAMEQEGATA AETEEQGHGG DTWDYKSHVM TKFAEEEDVR
260 270 280 290 300
RSFENTAADW PEMQTLAGAF DSDRWGFRPR TVVLHGKSGI GKSALARRIV
310 320 330 340 350
LCWAQGGLYQ GMFSYVFFLP VREMQRKKES SVTEFISREW PDSQAPVTEI
360 370 380 390 400
MSRPERLLFI IDGFDDLGSV LNNDTKLCKD WAEKQPPFTL IRSLLRKVLL
410 420 430 440 450
PESFLIVTVR DVGTEKLKSE VVSPRYLLVR GISGEQRIHL LLERGIGEHQ
460 470 480 490 500
KTQGLRAIMN NRELLDQCQV PAVGSLICVA LQLQDVVGES VAPFNQTLTG
510 520 530 540 550
LHAAFVFHQL TPRGVVRRCL NLEERVVLKR FCRMAVEGVW NRKSVFDGDD
560 570 580 590 600
LMVQGLGESE LRALFHMNIL LPDSHCEEYY TFFHLSLQDF CAALYYVLEG
610 620 630 640 650
LEIEPALCPL YVEKTKRSME LKQAGFHIHS LWMKRFLFGL VSEDVRRPLE
660 670 680 690 700
VLLGCPVPLG VKQKLLHWVS LLGQQPNATT PGDTLDAFHC LFETQDKEFV
710 720 730 740 750
RLALNSFQEV WLPINQNLDL IASSFCLQHC PYLRKIRVDV KGIFPRDESA
760 770 780 790 800
EACPVVPLWM RDKTLIEEQW EDFCSMLGTH PHLRQLDLGS SILTERAMKT
810 820 830 840 850
LCAKLRHPTC KIQTLMFRNA QITPGVQHLW RIVMANRNLR SLNLGGTHLK
860 870 880 890 900
EEDVRMACEA LKHPKCLLES LRLDCCGLTH ACYLKISQIL TTSPSLKSLS
910 920 930 940 950
LAGNKVTDQG VMPLSDALRV SQCALQKLIL EDCGITATGC QSLASALVSN
960 970 980 990 1000
RSLTHLCLSN NSLGNEGVNL LCRSMRLPHC SLQRLMLNQC HLDTAGCGFL
1010 1020 1030 1040 1050
ALALMGNSWL THLSLSMNPV EDNGVKLLCE VMREPSCHLQ DLELVKCHLT
1060 1070 1080 1090 1100
AACCESLSCV ISRSRHLKSL DLTDNALGDG GVAALCEGLK QKNSVLARLG
1110 1120 1130 1140 1150
LKACGLTSDC CEALSLALSC NRHLTSLNLV QNNFSPKGMM KLCSAFACPT
1160 1170 1180 1190 1200
SNLQIIGLWK WQYPVQIRKL LEEVQLLKPR VVIDGSWHSF DEDDRYWWKN
Length:1,200
Mass (Da):134,342
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1C6DB1003A2A1BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXM3A0A087WXM3_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP5
1,200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0W4M0R0W4_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP5
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti506V → A in AAL15549 (PubMed:11925379).Curated1
Sequence conflicti999F → S in AAL15549 (PubMed:11925379).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060095459M → I1 PublicationCorresponds to variant dbSNP:rs471979Ensembl.1
Natural variantiVAR_060096584H → P. Corresponds to variant dbSNP:rs34395092Ensembl.1
Natural variantiVAR_060097761R → L. Corresponds to variant dbSNP:rs17713875Ensembl.1
Natural variantiVAR_060098912M → T1 PublicationCorresponds to variant dbSNP:rs16986899Ensembl.1
Natural variantiVAR_0600991097A → T2 PublicationsCorresponds to variant dbSNP:rs3103057Ensembl.1
Natural variantiVAR_0601001108S → C. Corresponds to variant dbSNP:rs12462795Ensembl.1
Natural variantiVAR_0601011181V → I. Corresponds to variant dbSNP:rs10409555Ensembl.1
Natural variantiVAR_0601021195R → Q. Corresponds to variant dbSNP:rs36118060Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY054986 mRNA Translation: AAL15549.1
AY154460 mRNA Translation: AAO18156.1
AC011470 Genomic DNA No translation available.
AC024580 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12938.1

NCBI Reference Sequences

More...
RefSeqi
NP_703148.4, NM_153447.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000390649; ENSP00000375063; ENSG00000171487

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
126206

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:126206

UCSC genome browser

More...
UCSCi
uc002qmj.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY054986 mRNA Translation: AAL15549.1
AY154460 mRNA Translation: AAO18156.1
AC011470 Genomic DNA No translation available.
AC024580 Genomic DNA No translation available.
CCDSiCCDS12938.1
RefSeqiNP_703148.4, NM_153447.4

3D structure databases

SMRiP59047
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125965, 10 interactors
CORUMiP59047
IntActiP59047, 8 interactors
STRINGi9606.ENSP00000375063

PTM databases

iPTMnetiP59047
PhosphoSitePlusiP59047

Polymorphism and mutation databases

BioMutaiNLRP5
DMDMi215274029

Proteomic databases

PaxDbiP59047
PeptideAtlasiP59047
PRIDEiP59047
ProteomicsDBi57122

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
126206
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390649; ENSP00000375063; ENSG00000171487
GeneIDi126206
KEGGihsa:126206
UCSCiuc002qmj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
126206
DisGeNETi126206

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NLRP5

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0040046
HGNCiHGNC:21269 NLRP5
HPAiHPA056271
MIMi609658 gene
neXtProtiNX_P59047
OpenTargetsiENSG00000171487
PharmGKBiPA162397970

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIY8 Eukaryota
ENOG4111BJJ LUCA
GeneTreeiENSGT00940000162898
HOGENOMiHOG000294064
InParanoidiP59047
KOiK22626
OMAiNSFQEVW
OrthoDBi114368at2759
PhylomeDBiP59047

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NLRP5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
126206

Protein Ontology

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PROi
PR:P59047

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171487 Expressed in 17 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiP59047 baseline and differential
GenevisibleiP59047 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR041267 NLRC_HD2
IPR041075 NOD2_WH
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13516 LRR_6, 5 hits
PF05729 NACHT, 1 hit
PF17776 NLRC4_HD2, 1 hit
PF17779 NOD2_WH, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50837 NACHT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNALP5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P59047
Secondary accession number(s): A8MTY4, Q86W29
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 25, 2008
Last modified: May 8, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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