Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor-transporting protein 1

Gene

RTP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.By similarity

GO - Molecular functioni

  • olfactory receptor binding Source: HGNC

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of bitter taste Source: GO_Central
  • protein insertion into membrane Source: HGNC
  • protein targeting to membrane Source: GO_Central

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-transporting protein 1
Alternative name(s):
3CxxC-type zinc finger protein 1
Gene namesi
Name:RTP1
Synonyms:Z3CXXC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000175077.5
HGNCiHGNC:28580 RTP1
MIMi609137 gene
neXtProtiNX_P59025

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 238CytoplasmicSequence analysisAdd BLAST238
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 263ExtracellularSequence analysis4

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175077
PharmGKBiPA143485604

Polymorphism and mutation databases

BioMutaiRTP1
DMDMi61252249

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001819881 – 263Receptor-transporting protein 1Add BLAST263

Proteomic databases

EPDiP59025
PaxDbiP59025
PeptideAtlasiP59025
PRIDEiP59025
ProteomicsDBi57108

PTM databases

iPTMnetiP59025
PhosphoSitePlusiP59025

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000175077 Expressed in 46 organ(s), highest expression level in oocyte
CleanExiHS_RTP1
GenevisibleiP59025 HS

Interactioni

Subunit structurei

Interacts with olfactory receptors.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311712

Structurei

3D structure databases

ProteinModelPortaliP59025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE69 Eukaryota
ENOG41119VJ LUCA
GeneTreeiENSGT00530000063222
HOGENOMiHOG000060180
HOVERGENiHBG079158
InParanoidiP59025
OMAiQDTRRHR
OrthoDBiEOG091G0DS4
PhylomeDBiP59025
TreeFamiTF333246

Family and domain databases

InterProiView protein in InterPro
IPR026096 R-trans_p
IPR026692 RTP1
IPR027377 Znf-3CxxC
PANTHERiPTHR14402 PTHR14402, 1 hit
PTHR14402:SF19 PTHR14402:SF19, 1 hit
PfamiView protein in Pfam
PF13695 zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit

Sequencei

Sequence statusi: Complete.

P59025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRIFRPWRLR CPALHLPSLS VFSLRWKLPS LTTDETMCKS VTTDEWKKVF
60 70 80 90 100
YEKMEEAKPA DSWDLIIDPN LKHNVLSPGW KQYLELHASG RFHCSWCWHT
110 120 130 140 150
WQSPYVVILF HMFLDRAQRA GSVRMRVFKQ LCYECGTARL DESSMLEENI
160 170 180 190 200
EGLVDNLITS LREQCYGERG GQYRIHVASR QDNRRHRGEF CEACQEGIVH
210 220 230 240 250
WKPSEKLLEE EATTYTFSRA PSPTKSQDQT GSGWNFCSIP WCLFWATVLL
260
LIIYLQFSFR SSV
Length:263
Mass (Da):30,913
Last modified:March 15, 2005 - v2
Checksum:i80B2F845DDC81F2B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036122124R → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053729212A → G. Corresponds to variant dbSNP:rs35053281Ensembl.1
Natural variantiVAR_053730229Q → E. Corresponds to variant dbSNP:rs6764714Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034744 mRNA Translation: AAH34744.4
BC065202 mRNA Translation: AAH65202.2
AY562235 mRNA Translation: AAT70680.1
CCDSiCCDS3287.2
RefSeqiNP_714919.2, NM_153708.2
UniGeneiHs.518480

Genome annotation databases

EnsembliENST00000312295; ENSP00000311712; ENSG00000175077
GeneIDi132112
KEGGihsa:132112
UCSCiuc003frg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034744 mRNA Translation: AAH34744.4
BC065202 mRNA Translation: AAH65202.2
AY562235 mRNA Translation: AAT70680.1
CCDSiCCDS3287.2
RefSeqiNP_714919.2, NM_153708.2
UniGeneiHs.518480

3D structure databases

ProteinModelPortaliP59025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311712

PTM databases

iPTMnetiP59025
PhosphoSitePlusiP59025

Polymorphism and mutation databases

BioMutaiRTP1
DMDMi61252249

Proteomic databases

EPDiP59025
PaxDbiP59025
PeptideAtlasiP59025
PRIDEiP59025
ProteomicsDBi57108

Protocols and materials databases

DNASUi132112
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312295; ENSP00000311712; ENSG00000175077
GeneIDi132112
KEGGihsa:132112
UCSCiuc003frg.3 human

Organism-specific databases

CTDi132112
EuPathDBiHostDB:ENSG00000175077.5
GeneCardsiRTP1
H-InvDBiHIX0024412
HGNCiHGNC:28580 RTP1
MIMi609137 gene
neXtProtiNX_P59025
OpenTargetsiENSG00000175077
PharmGKBiPA143485604
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE69 Eukaryota
ENOG41119VJ LUCA
GeneTreeiENSGT00530000063222
HOGENOMiHOG000060180
HOVERGENiHBG079158
InParanoidiP59025
OMAiQDTRRHR
OrthoDBiEOG091G0DS4
PhylomeDBiP59025
TreeFamiTF333246

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GenomeRNAii132112
PROiPR:P59025
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175077 Expressed in 46 organ(s), highest expression level in oocyte
CleanExiHS_RTP1
GenevisibleiP59025 HS

Family and domain databases

InterProiView protein in InterPro
IPR026096 R-trans_p
IPR026692 RTP1
IPR027377 Znf-3CxxC
PANTHERiPTHR14402 PTHR14402, 1 hit
PTHR14402:SF19 PTHR14402:SF19, 1 hit
PfamiView protein in Pfam
PF13695 zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTP1_HUMAN
AccessioniPrimary (citable) accession number: P59025
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 15, 2005
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again