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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei130SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation, Transcription termination

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:spyM18_0890
OrganismiStreptococcus pyogenes serotype M18 (strain MGAS8232)
Taxonomic identifieri186103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830691 – 173Bifunctional protein PyrRAdd BLAST173

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP59013
SMRiP59013
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni40 – 41Substrate-bindingBy similarity2
Regioni97 – 105Substrate bindingBy similarity9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi93 – 105PRPP-bindingUniRule annotationAdd BLAST13

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000245770
KOiK02825
OMAiRISHEIL

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01219 PyrR, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023050 PyrR
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit

Sequencei

Sequence statusi: Complete.

P59013-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTKEIVDDV TMKRAITRIT YEIIERNKQL DNVVLAGIKT RGVFLARRIQ
60 70 80 90 100
ERLHQLEGLD LPIGELDTKP FRDDMRVEED TTLMSVDITG KDVILIDDVL
110 120 130 140 150
YTGRTIRAAI DNLVSLGRPA RVSLAVLVDR GHRELPIRAD YVGKNIPTSS
160 170
VEEIVVEVVE VDGRDRVSII DPT
Length:173
Mass (Da):19,517
Last modified:August 30, 2002 - v1
Checksum:iE4E6A11288DE7A22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009949 Genomic DNA Translation: AAL97542.1
RefSeqiWP_009881107.1, NC_003485.1

Genome annotation databases

EnsemblBacteriaiAAL97542; AAL97542; spyM18_0890
KEGGispm:spyM18_0890

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009949 Genomic DNA Translation: AAL97542.1
RefSeqiWP_009881107.1, NC_003485.1

3D structure databases

ProteinModelPortaliP59013
SMRiP59013
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL97542; AAL97542; spyM18_0890
KEGGispm:spyM18_0890

Phylogenomic databases

HOGENOMiHOG000245770
KOiK02825
OMAiRISHEIL

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01219 PyrR, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023050 PyrR
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPYRR_STRP8
AccessioniPrimary (citable) accession number: P59013
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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