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Protein

Glucocorticoid modulatory element-binding protein 2

Gene

Gmeb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi110ZincBy similarity1
Binding sitei136DNABy similarity1
Binding sitei140DNABy similarity1
Binding sitei143DNABy similarity1
Binding sitei154DNABy similarity1
Metal bindingi167ZincBy similarity1
Metal bindingi171ZincBy similarity1
Metal bindingi175ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glucocorticoid modulatory element-binding protein 2
Short name:
GMEB-2
Gene namesi
Name:Gmeb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2652836 Gmeb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740931 – 530Glucocorticoid modulatory element-binding protein 2Add BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei373PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP58929
MaxQBiP58929
PaxDbiP58929
PeptideAtlasiP58929
PRIDEiP58929

PTM databases

iPTMnetiP58929
PhosphoSitePlusiP58929

Expressioni

Gene expression databases

BgeeiENSMUSG00000038705 Expressed in 223 organ(s), highest expression level in bone marrow
ExpressionAtlasiP58929 baseline and differential
GenevisibleiP58929 MM

Interactioni

Subunit structurei

Homodimer, and heterodimer of GMEB1 and GMEB2. Interacts with the glucocorticoid receptor (NR3C1). May interact with CREB-binding protein (CBP) (By similarity).By similarity

Protein-protein interaction databases

BioGridi230807, 11 interactors
IntActiP58929, 1 interactor
MINTiP58929
STRINGi10090.ENSMUSP00000037075

Structurei

3D structure databases

ProteinModelPortaliP58929
SMRiP58929
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 163SANDPROSITE-ProRule annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili245 – 270Sequence analysisAdd BLAST26
Coiled coili304 – 344Sequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 16Poly-Val4
Compositional biasi57 – 64Poly-Ala8

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4333 Eukaryota
ENOG410ZMTP LUCA
GeneTreeiENSGT00410000025596
HOGENOMiHOG000231857
HOVERGENiHBG051742
InParanoidiP58929
OMAiALEQQCD
OrthoDBiEOG091G07Q9
PhylomeDBiP58929
TreeFamiTF317090

Family and domain databases

Gene3Di3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR024830 GMEB1/2
IPR010919 SAND-like_dom_sf
IPR000770 SAND_dom
PANTHERiPTHR10417 PTHR10417, 1 hit
PfamiView protein in Pfam
PF01342 SAND, 1 hit
SMARTiView protein in SMART
SM00258 SAND, 1 hit
SUPFAMiSSF63763 SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS50864 SAND, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P58929-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPDVSVHM EEVVVVTTPD TAVDGSGVEE VKTVLVTTNL APHGGDLTED
60 70 80 90 100
NMETENAAAA AAAAFTASSQ LKEAVLVKMA EEGENLEAEI VYPITCGDSR
110 120 130 140 150
ANLIWRKFVC PGINVKCVQY DEHVISPKEF VHLAGKSTLK DWKRAIRMNG
160 170 180 190 200
IMLRKIMDSG ELDFYQHDKV CSNTCRSTKI DLSGARVSLS SPTSTEYIPL
210 220 230 240 250
TPAAADVNGS PATITIETCE DPGDWTTTIG DDTFAFWRGL KDAGLLDEVI
260 270 280 290 300
QEFQQELEET MKGLQQRVQD PPLQLRDAVL LNNIVQNFGM LDLVKKVLAS
310 320 330 340 350
HKCQMDRSRE QYARDLAALE QQCDEHRRRA KELKHKSQHL SNVLMTLTPV
360 370 380 390 400
PLPSPMKRPR LARATSGPAA MASQVLTQSA QIALSPGMPV SQLTSVPLGK
410 420 430 440 450
VVSTLPSTVL GKGSPQAAPA SSPASPLLGG YTVLASSGST FPNAVEIHPD
460 470 480 490 500
TSSLTVLSTA AMQDGSTVLK VVSPLQLLTL PGLGPTLQNV AQASPAGSTI
510 520 530
VTMPTATATG PEEHTATIEV AAVAEDHEQK
Length:530
Mass (Da):56,631
Last modified:October 25, 2005 - v2
Checksum:i9CFF4660A1CB97ED
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AS07A2AS07_MOUSE
Glucocorticoid modulatory element-b...
Gmeb2
215Annotation score:
D6RGU7D6RGU7_MOUSE
Glucocorticoid modulatory element-b...
Gmeb2
127Annotation score:
D6RG43D6RG43_MOUSE
Glucocorticoid modulatory element-b...
Gmeb2
78Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029763 mRNA Translation: AAH29763.1
BC059066 mRNA Translation: AAH59066.1
CCDSiCCDS17206.1
RefSeqiNP_937812.1, NM_198169.2
XP_006500665.1, XM_006500602.2
XP_006500666.1, XM_006500603.1
XP_006500667.1, XM_006500604.1
XP_006500668.1, XM_006500605.2
UniGeneiMm.220423

Genome annotation databases

EnsembliENSMUST00000049032; ENSMUSP00000037075; ENSMUSG00000038705
GeneIDi229004
KEGGimmu:229004
UCSCiuc008olq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029763 mRNA Translation: AAH29763.1
BC059066 mRNA Translation: AAH59066.1
CCDSiCCDS17206.1
RefSeqiNP_937812.1, NM_198169.2
XP_006500665.1, XM_006500602.2
XP_006500666.1, XM_006500603.1
XP_006500667.1, XM_006500604.1
XP_006500668.1, XM_006500605.2
UniGeneiMm.220423

3D structure databases

ProteinModelPortaliP58929
SMRiP58929
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230807, 11 interactors
IntActiP58929, 1 interactor
MINTiP58929
STRINGi10090.ENSMUSP00000037075

PTM databases

iPTMnetiP58929
PhosphoSitePlusiP58929

Proteomic databases

EPDiP58929
MaxQBiP58929
PaxDbiP58929
PeptideAtlasiP58929
PRIDEiP58929

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049032; ENSMUSP00000037075; ENSMUSG00000038705
GeneIDi229004
KEGGimmu:229004
UCSCiuc008olq.1 mouse

Organism-specific databases

CTDi26205
MGIiMGI:2652836 Gmeb2

Phylogenomic databases

eggNOGiKOG4333 Eukaryota
ENOG410ZMTP LUCA
GeneTreeiENSGT00410000025596
HOGENOMiHOG000231857
HOVERGENiHBG051742
InParanoidiP58929
OMAiALEQQCD
OrthoDBiEOG091G07Q9
PhylomeDBiP58929
TreeFamiTF317090

Miscellaneous databases

PROiPR:P58929
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038705 Expressed in 223 organ(s), highest expression level in bone marrow
ExpressionAtlasiP58929 baseline and differential
GenevisibleiP58929 MM

Family and domain databases

Gene3Di3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR024830 GMEB1/2
IPR010919 SAND-like_dom_sf
IPR000770 SAND_dom
PANTHERiPTHR10417 PTHR10417, 1 hit
PfamiView protein in Pfam
PF01342 SAND, 1 hit
SMARTiView protein in SMART
SM00258 SAND, 1 hit
SUPFAMiSSF63763 SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS50864 SAND, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGMEB2_MOUSE
AccessioniPrimary (citable) accession number: P58929
Secondary accession number(s): Q6PCY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: October 25, 2005
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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