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Protein

Conotoxin CcTx

Gene
N/A
Organism
Conus consors (Singed cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May specifically activate neuronal voltage-gated sodium channels (Nav) at the resting membrane potential. Causes a marked contraction and extension of the caudal and dorsal fins in fish and noticeable spontaneous contractions of isolated frog neuromuscular preparations.1 Publication

Miscellaneous

Found in both injectable (milked) (IV) and dissected venom (DV).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin CcTx
Alternative name(s):
Excitotoxin CcTx
OrganismiConus consors (Singed cone)
Taxonomic identifieri101297 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri1510 CcTx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000445141 – 30Conotoxin CcTxAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24-hydroxyproline1 Publication1
Glycosylationi7O-linked (HexNAc...) serine2 Publications1
Disulfide bondi12 ↔ 21Combined sources1 Publication
Disulfide bondi13 ↔ 26Combined sources1 Publication
Modified residuei174-hydroxyproline1 Publication1
Modified residuei224-hydroxyproline1 Publication1
Disulfide bondi24 ↔ 30Combined sources1 Publication

Post-translational modificationi

O-glycosylated at Ser-7 by a core type 9 glycan, containing both D- and L-galactose units (alpha-L-Galp-(1->4)-alpha-D- GlcpNAc-(1->6)-[alpha-L-Galp-(1->2)-bets-D-Galp-(1->3)-]alpha-D-GalpNAc-(1->O)).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

PTM databases

iPTMnetiP58928

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

Secondary structure

130
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP58928
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is IV (CC-C-C-C-C).

Sequencei

Sequence statusi: Complete.

P58928-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30
APWLVPSQIT TCCGYNPGTM CPSCMCTNTC
Length:30
Mass (Da):3,184
Last modified:March 23, 2010 - v2
Checksum:iAD8E9CC5ABB0E065
GO

Mass spectrometryi

Molecular mass is 3223 Da from positions 1 - 30. Determined by ESI. Non-glycosylated form.1 Publication
Molecular mass is 4156 Da from positions 1 - 30. Determined by ESI. Glycosylated form.1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B1QNMR-P1-30[»]
SMRiP58928
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP58928

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1510 CcTx

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCEX_CONCN
AccessioniPrimary (citable) accession number: P58928
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: March 23, 2010
Last modified: September 12, 2018
This is version 53 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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