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Protein

Mu-conotoxin PnIVB

Gene
N/A
Organism
Conus pennaceus (Feathered cone) (Conus episcopus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mu-conotoxins block voltage-gated sodium channels (Nav). Blocks reversibly sodium channels in molluskan neurons, but has no effect on sodium currents in bovine chromaffin cells or in rat brain synaptosomes. Induces paralysis in bivalve mollusks (Mytilus). No effect are observed on fish (Gambusia) and fly larvae (Sarcophaga). Is approximately 6 times more potent than PnIVA in blockade of the sodium current in Lymnaea neurons.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57Important for binding and activityBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-conotoxin PnIVB
OrganismiConus pennaceus (Feathered cone) (Conus episcopus)
Taxonomic identifieri37335 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusDarioconus

Organism-specific databases

ConoServeri1559 PnIVB
618 PnIVB precursor
771 PnIVB precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000039272521 – 511 PublicationAdd BLAST31
PeptideiPRO_000004449754 – 70Mu-conotoxin PnIVB1 PublicationAdd BLAST17

Post-translational modificationi

Contains 3 disulfide bonds (By similarity). They are not added, since framework IV presents two different connectivities (I-V, II-III, IV-VI and I-III, II-V, IV-VI).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP58927

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is IV (CC-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin M superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214 Conotoxin
PfamiView protein in Pfam
PF02950 Conotoxin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58927-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSKLGVLLI ICLLLCPLTA VPQDGDQPAD QPAERMQDDI SSEHHPFFDP
60 70
VKRCCKYGWT CWLGCSPCGC
Length:70
Mass (Da):7,770
Last modified:March 23, 2010 - v2
Checksum:i8A90EEDF3F90B301
GO

Mass spectrometryi

Molecular mass is 1862.8 Da from positions 54 - 70. Determined by LSI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214931 mRNA Translation: AAG60359.1
AF215093 mRNA Translation: AAG60514.1
AF215094 mRNA Translation: AAG60515.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214931 mRNA Translation: AAG60359.1
AF215093 mRNA Translation: AAG60514.1
AF215094 mRNA Translation: AAG60515.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP58927

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1559 PnIVB
618 PnIVB precursor
771 PnIVB precursor

Family and domain databases

InterProiView protein in InterPro
IPR004214 Conotoxin
PfamiView protein in Pfam
PF02950 Conotoxin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCM4B_CONPE
AccessioniPrimary (citable) accession number: P58927
Secondary accession number(s): Q9BH61, Q9BP54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: March 23, 2010
Last modified: September 12, 2018
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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