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Protein

Mu-conotoxin PnIVA

Gene
N/A
Organism
Conus pennaceus (Feathered cone) (Conus episcopus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mu-conotoxins block voltage-gated sodium channels (Nav). Blocks reversibly sodium channels in molluskan neurons, but has no effect on sodium currents in bovine chromaffin cells or in rat brain synaptosomes. Induces paralysis in bivalve mollusks (Mytilus). No effect are observed on fish (Gambusia) and fly larvae (Sarcophaga). PnIVB is approximately 6 times more potent than PnIVA in blockade of the sodium current in Lymnaea neurons.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei4Important for binding and activity1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-conotoxin PnIVA
OrganismiConus pennaceus (Feathered cone) (Conus episcopus)
Taxonomic identifieri37335 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusDarioconus

Organism-specific databases

ConoServeri1560 PnIVA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444961 – 17Mu-conotoxin PnIVAAdd BLAST17

Post-translational modificationi

Contains 3 disulfide bonds (By similarity). They are not added, since framework IV presents two different connectivities (I-V, II-III, IV-VI and I-III, II-V, IV-VI).By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is IV (CC-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin M superfamily.Curated

Sequencei

Sequence statusi: Complete.

Length:17
Mass (Da):1,797
Last modified:July 26, 2002 - v1
Checksum:iF9B721E0E96B9D82
GO

Mass spectrometryi

Molecular mass is 1789.5 Da from positions 1 - 17. Determined by LSI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1560 PnIVA

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCM4A_CONPE
AccessioniPrimary (citable) accession number: P58926
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 26, 2002
Last modified: September 12, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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