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Protein

Conotoxin TVIIA

Gene
N/A
Organism
Conus tulipa (Fish-hunting cone snail) (Tulip cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

By structural similarity with conotoxin GS, may inhibit the sodium channel (Nav). No effect was observed upon intracranial injections into mice and intraperitoneal injections into goldfish (25 µg).

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin TVIIA2 Publications
OrganismiConus tulipa (Fish-hunting cone snail) (Tulip cone)
Taxonomic identifieri6495 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusGastridium

Organism-specific databases

ConoServeri1405 TVIIA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444881 – 30Conotoxin TVIIAAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 141 PublicationImported
Disulfide bondi9 ↔ 191 PublicationImported
Modified residuei104-hydroxyproline1 Publication1
Modified residuei114-hydroxyproline1 Publication1
Disulfide bondi13 ↔ 241 PublicationImported

Post-translational modificationi

Three different forms of TVIIA exist. Pro-10 and Pro-11 of conotoxin TVIIA are hydroxylated in TVIIA, whereas Pro-10 is not hydroxylated in [Pro10]TVIIA and neither Pro-10 nor Pro-11 are hydroxylated in [Pro10,11]TVIIA.1 Publication

Keywords - PTMi

Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

Secondary structure

130
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP58923
SMRiP58923
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58923

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.1 Publication
The cysteine framework is VI/VII (C-C-CC-C-C).Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR012629 Conotoxin_TVIIAGS
PfamiView protein in Pfam
PF08094 Toxin_24, 1 hit

Sequencei

Sequence statusi: Complete.

P58923-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30
SCSGRDSRCP PVCCMGLMCS RGKCVSIYGE
Length:30
Mass (Da):3,186
Last modified:July 26, 2002 - v1
Checksum:iD9419BC6F0DB7A30
GO

Mass spectrometryi

Molecular mass is 3212.4 Da from positions 1 - 30. Determined by ESI. TVIIA with hydroxyPro-10 and hydroxyPro-11.1 Publication
Molecular mass is 3196.0 Da from positions 1 - 30. Determined by ESI. [Pro10]TVIIA with hydroxyPro-11.1 Publication
Molecular mass is 3180.0 Da from positions 1 - 30. Determined by ESI. [Pro10,Pro11]TVIIA.1 Publication

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EYONMR-A1-30[»]
ProteinModelPortaliP58923
SMRiP58923
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1405 TVIIA

Miscellaneous databases

EvolutionaryTraceiP58923

Family and domain databases

InterProiView protein in InterPro
IPR012629 Conotoxin_TVIIAGS
PfamiView protein in Pfam
PF08094 Toxin_24, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiU7A_CONTU
AccessioniPrimary (citable) accession number: P58923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 26, 2002
Last modified: October 10, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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