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Protein

Kurtoxin

Gene
N/A
Organism
Parabuthus transvaalicus (South African fattail scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin acts on Nav1.2/SCN2A. Also binds to Cav3.1/CACNA1G and Cav3.2/CACNA1H T-type calcium channels with high affinity and inhibits the channels by modifying voltage-dependent gating. Another study (PubMed:11896142) shows that it also targets neuronal high-threshold calcium channels, including P-type, N-type, and L-type calcium channels (Cav), and others that still are unidentified pharmacologically.2 Publications

Miscellaneous

This toxin does not affect Cav1.2/CACNA1C, Cav2.1/CACNA1A, Cav2.2/CACNA1B, and Cav2.3/CACNA1E calcium channels.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kurtoxin
Short name:
Ktx
OrganismiParabuthus transvaalicus (South African fattail scorpion)
Taxonomic identifieri170972 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeParabuthus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000667921 – 63KurtoxinAdd BLAST63

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi12 ↔ 61PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi16 ↔ 37PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi23 ↔ 44PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi27 ↔ 46PROSITE-ProRule annotation1 PublicationImported

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP58910
SMRiP58910
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58910

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 62LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Family and domain databases

CDDicd00107 Knot1, 1 hit
Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
IPR018218 Scorpion_toxinL
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
PRINTSiPR00285 SCORPNTOXIN
SMARTiView protein in SMART
SM00505 Knot1, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit

Sequencei

Sequence statusi: Complete.

P58910-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KIDGYPVDYW NCKRICWYNN KYCNDLCKGL KADSGYCWGW TLSCYCQGLP
60
DNARIKRSGR CRA
Length:63
Mass (Da):7,394
Last modified:July 26, 2002 - v1
Checksum:i870B1E47F2DF991C
GO

Mass spectrometryi

Molecular mass is 7386.1 Da from positions 1 - 63. Determined by ESI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T1TNMR-A1-63[»]
ProteinModelPortaliP58910
SMRiP58910
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP58910

Family and domain databases

CDDicd00107 Knot1, 1 hit
Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
IPR018218 Scorpion_toxinL
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
PRINTSiPR00285 SCORPNTOXIN
SMARTiView protein in SMART
SM00505 Knot1, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKURT_PARTR
AccessioniPrimary (citable) accession number: P58910
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 26, 2002
Last modified: September 12, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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