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Protein

Opticin

Gene

OPTC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds collagen fibrils.By similarity

Enzyme and pathway databases

ReactomeiR-BTA-1474228 Degradation of the extracellular matrix

Names & Taxonomyi

Protein namesi
Recommended name:
Opticin
Alternative name(s):
Oculoglycan
Gene namesi
Name:OPTC
Synonyms:OPT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:32441 OPTC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000018008720 – 321OpticinAdd BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61SulfotyrosineSequence analysis1
Disulfide bondi278 ↔ 311By similarity
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

O-glycosylated (sialylated oligosaccharides).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PaxDbiP58874
PRIDEiP58874

Miscellaneous databases

PMAP-CutDBiP58874

Expressioni

Gene expression databases

BgeeiENSBTAG00000013764 Expressed in 8 organ(s), highest expression level in prefrontal cortex

Interactioni

Subunit structurei

Dimer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018286

Structurei

3D structure databases

ProteinModelPortaliP58874
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 142LRRNTAdd BLAST38
Repeati143 – 164LRR 1Add BLAST22
Repeati167 – 188LRR 2Add BLAST22
Repeati191 – 212LRR 3Add BLAST22
Repeati237 – 258LRR 4Add BLAST22
Repeati259 – 279LRR 5Add BLAST21
Repeati289 – 309LRR 6Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi71 – 102Ser/Thr-richAdd BLAST32
Compositional biasi117 – 129Cys-richAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00730000110781
HOGENOMiHOG000273909
HOVERGENiHBG006850
InParanoidiP58874
KOiK08128
OMAiFCDPEEH
OrthoDBiEOG091G0E8Y
TreeFamiTF351924

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 4 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58874-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLALLSLL ILMLQEARTA SLSEEREGDP YAILHLGDYV LSLDNYDEVI
60 70 80 90 100
DPSNYDELID YGDQLPQVKG TSLASLTRTR FTQSTEAART LPSNPTTARP
110 120 130 140 150
PTLGLLAAPA NHGLPTCLIC VCLGSSVYCD DADLENIPPL PQTTAYLYAR
160 170 180 190 200
FNRISHIRAG DFKGLTKLKR IDLSGNSISS IDDKALRLLP ALRDLILPEN
210 220 230 240 250
KLVALPTLPT SIEVLDVRMN RLQSSGIQPE AFRALEKLQF LYLADNLLDA
260 270 280 290 300
IPPSLPLSLR SLHLQNNMIE TMQRDAFCDA EEHRHTRRPL EDIRLDGNPI
310 320
NLSLFPSAYF CLPRLPTGRF V
Length:321
Mass (Da):35,731
Last modified:June 27, 2006 - v2
Checksum:iFB87F0CEEE7E0EC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23S → P AA sequence (PubMed:10636917).Curated1
Sequence conflicti189L → Q AA sequence (PubMed:10636917).Curated1
Sequence conflicti243L → A AA sequence (PubMed:10636917).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY249537 mRNA Translation: AAP76303.1
RefSeqiNP_991339.1, NM_205770.1
XP_005216715.1, XM_005216658.3
UniGeneiBt.88120

Genome annotation databases

EnsembliENSBTAT00000018286; ENSBTAP00000018286; ENSBTAG00000013764
GeneIDi404034
KEGGibta:404034

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY249537 mRNA Translation: AAP76303.1
RefSeqiNP_991339.1, NM_205770.1
XP_005216715.1, XM_005216658.3
UniGeneiBt.88120

3D structure databases

ProteinModelPortaliP58874
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018286

Proteomic databases

PaxDbiP58874
PRIDEiP58874

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018286; ENSBTAP00000018286; ENSBTAG00000013764
GeneIDi404034
KEGGibta:404034

Organism-specific databases

CTDi26254
VGNCiVGNC:32441 OPTC

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00730000110781
HOGENOMiHOG000273909
HOVERGENiHBG006850
InParanoidiP58874
KOiK08128
OMAiFCDPEEH
OrthoDBiEOG091G0E8Y
TreeFamiTF351924

Enzyme and pathway databases

ReactomeiR-BTA-1474228 Degradation of the extracellular matrix

Miscellaneous databases

PMAP-CutDBiP58874

Gene expression databases

BgeeiENSBTAG00000013764 Expressed in 8 organ(s), highest expression level in prefrontal cortex

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 4 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOPT_BOVIN
AccessioniPrimary (citable) accession number: P58874
Secondary accession number(s): P83285, Q6X8P9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 27, 2006
Last modified: November 7, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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