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Entry version 142 (02 Jun 2021)
Sequence version 2 (29 May 2007)
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Protein

182 kDa tankyrase-1-binding protein

Gene

Tnks1bp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-429947, Deadenylation of mRNA
R-MMU-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
182 kDa tankyrase-1-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tnks1bp1
Synonyms:Kiaa1741, Tab182
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2446193, Tnks1bp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724381 – 1720182 kDa tankyrase-1-binding proteinAdd BLAST1720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineBy similarity1
Modified residuei131PhosphothreonineBy similarity1
Modified residuei178PhosphoserineBy similarity1
Modified residuei220PhosphoserineBy similarity1
Modified residuei238PhosphothreonineBy similarity1
Modified residuei286PhosphoserineBy similarity1
Modified residuei300PhosphoserineCombined sources1
Modified residuei429PhosphoserineCombined sources1
Modified residuei437PhosphoserineBy similarity1
Modified residuei496PhosphoserineCombined sources1
Modified residuei500PhosphoserineCombined sources1
Modified residuei503PhosphothreonineCombined sources1
Modified residuei533PhosphothreonineCombined sources1
Modified residuei539PhosphoserineCombined sources1
Modified residuei568PhosphoserineCombined sources1
Modified residuei602PhosphoserineBy similarity1
Modified residuei673PhosphoserineBy similarity1
Modified residuei692PhosphoserineBy similarity1
Modified residuei713PhosphoserineCombined sources1
Modified residuei763PhosphoserineBy similarity1
Modified residuei796PhosphoserineCombined sources1
Modified residuei807PhosphoserineBy similarity1
Modified residuei845PhosphoserineBy similarity1
Modified residuei866PhosphoserineBy similarity1
Modified residuei871PhosphoserineBy similarity1
Modified residuei876PhosphoserineBy similarity1
Modified residuei887PhosphoserineCombined sources1
Modified residuei912PhosphoserineBy similarity1
Modified residuei976PhosphoserineBy similarity1
Modified residuei980PhosphoserineBy similarity1
Modified residuei1006PhosphoserineBy similarity1
Modified residuei1017PhosphoserineBy similarity1
Modified residuei1022PhosphoserineCombined sources1
Modified residuei1047PhosphoserineBy similarity1
Modified residuei1063PhosphoserineCombined sources1
Modified residuei1084PhosphoserineBy similarity1
Modified residuei1096PhosphoserineBy similarity1
Modified residuei1126PhosphoserineBy similarity1
Modified residuei1131PhosphoserineCombined sources1
Modified residuei1171PhosphoserineBy similarity1
Modified residuei1212PhosphoserineCombined sources1
Modified residuei1241PhosphoserineBy similarity1
Modified residuei1246PhosphoserineCombined sources1
Modified residuei1275PhosphothreonineCombined sources1
Modified residuei1290PhosphoserineCombined sources1
Modified residuei1321PhosphoserineBy similarity1
Modified residuei1324PhosphoserineBy similarity1
Modified residuei1373PhosphoserineCombined sources1
Modified residuei1375PhosphoserineCombined sources1
Modified residuei1425PhosphoserineBy similarity1
Modified residuei1429PhosphoserineBy similarity1
Modified residuei1437PhosphoserineCombined sources1
Modified residuei1440PhosphoserineBy similarity1
Modified residuei1442PhosphoserineCombined sources1
Modified residuei1463PhosphoserineBy similarity1
Modified residuei1466PhosphoserineBy similarity1
Modified residuei1496PhosphoserineBy similarity1
Modified residuei1549PhosphoserineBy similarity1
Modified residuei1554PhosphothreonineBy similarity1
Modified residuei1611PhosphoserineCombined sources1
Modified residuei1612PhosphoserineCombined sources1
Modified residuei1622PhosphoserineBy similarity1
Modified residuei1635N6-methyllysineBy similarity1
Modified residuei1643PhosphoserineBy similarity1
Modified residuei1657PhosphoserineCombined sources1
Modified residuei1706PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ADP-ribosylated by TNKS1.By similarity

Keywords - PTMi

ADP-ribosylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P58871

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P58871

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P58871

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P58871

PeptideAtlas

More...
PeptideAtlasi
P58871

PRoteomics IDEntifications database

More...
PRIDEi
P58871

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
263070

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P58871

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P58871

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033955, Expressed in stomach and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P58871, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P58871, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the ANK repeat domain of TNKS1 and TNKS2.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
230718, 15 interactors

Protein interaction database and analysis system

More...
IntActi
P58871, 14 interactors

Molecular INTeraction database

More...
MINTi
P58871

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000107232

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P58871, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 137DisorderedSequence analysisAdd BLAST137
Regioni185 – 472DisorderedSequence analysisAdd BLAST288
Regioni209 – 1563AcidicAdd BLAST1355
Regioni485 – 595DisorderedSequence analysisAdd BLAST111
Regioni659 – 720DisorderedSequence analysisAdd BLAST62
Regioni734 – 925DisorderedSequence analysisAdd BLAST192
Regioni955 – 1081DisorderedSequence analysisAdd BLAST127
Regioni1128 – 1153DisorderedSequence analysisAdd BLAST26
Regioni1198 – 1255DisorderedSequence analysisAdd BLAST58
Regioni1358 – 1546DisorderedSequence analysisAdd BLAST189
Regioni1440 – 1532Tankyrase-bindingBy similarityAdd BLAST93
Regioni1567 – 1720DisorderedSequence analysisAdd BLAST154

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1620 – 1626Nuclear localization signalSequence analysis7
Motifi1714 – 1719Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi58 – 72Pro residuesSequence analysisAdd BLAST15
Compositional biasi265 – 334Polar residuesSequence analysisAdd BLAST70
Compositional biasi362 – 376Polar residuesSequence analysisAdd BLAST15
Compositional biasi418 – 472Polar residuesSequence analysisAdd BLAST55
Compositional biasi664 – 680Polar residuesSequence analysisAdd BLAST17
Compositional biasi734 – 762Polar residuesSequence analysisAdd BLAST29
Compositional biasi780 – 794Polar residuesSequence analysisAdd BLAST15
Compositional biasi837 – 862Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi970 – 984Polar residuesSequence analysisAdd BLAST15
Compositional biasi986 – 1011Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1044 – 1065Polar residuesSequence analysisAdd BLAST22
Compositional biasi1398 – 1415Polar residuesSequence analysisAdd BLAST18
Compositional biasi1425 – 1462Polar residuesSequence analysisAdd BLAST38
Compositional biasi1511 – 1525Polar residuesSequence analysisAdd BLAST15
Compositional biasi1596 – 1622Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1652 – 1667Basic and acidic residuesSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSXZ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154184

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003005_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P58871

Identification of Orthologs from Complete Genome Data

More...
OMAi
WAGDFSL

Database of Orthologous Groups

More...
OrthoDBi
64879at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P58871

TreeFam database of animal gene trees

More...
TreeFami
TF336029

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032764, Tankyrase-bd_C
IPR040006, TNKS1BP1-like

The PANTHER Classification System

More...
PANTHERi
PTHR22042, PTHR22042, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15327, Tankyrase_bdg_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01319, Tankyrase_bdg_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P58871-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGSTLREGT AMASPLPQDM EEELAPVGSE PGDPRAKPPV KPKPRGLPSK
60 70 80 90 100
PALPAKPSLL VPVGPRPPRG PLAELPSARK MNMLAGPQPY GVSKRPLPFA
110 120 130 140 150
PRPSAEATAG GDVTQESGKE DAGKEDLPPL TPPARCAALG GVRKAPAPFR
160 170 180 190 200
PSSERFAACT VEEILAKMEQ PRKEILASPD RLWGSRLTFN HDGSSRYGPR
210 220 230 240 250
TYGAPCPREE DSKSPAKGRS QEGTAEIPAE CQEEHSKTPE ERNLTSSPAM
260 270 280 290 300
NGDLAKLACS EAPTDVSKTW VTSSADPVSE HGGSTSAVRL ANISVPASES
310 320 330 340 350
PRLSSRPSSP CHSQLSETQS PAASEASSIC LPVTPASPSA VLPAEPPGHS
360 370 380 390 400
PSSELPAEAA PETLSPNSSP VETVSGHHSP EQPPVLLPQL LTEGAELPDI
410 420 430 440 450
TRTFPCGEEA AARGHTESRP SSLAQRRFSE GVLQPPSQDQ EKLGGSLATL
460 470 480 490 500
PQGQGSQSAL DRPFGSGTES NWSLSQSFEW TFPTRPSGLG VWRLDSPPPS
510 520 530 540 550
PITEASEAAE AAEADSWAVS GRGEGVSQVG PGTPPAPESP RKPISGVQGN
560 570 580 590 600
DPGISLPQRD DGESQPRSPA LLPSTVEGPP GAPLLQAKEN YEDQEPLVGH
610 620 630 640 650
ESPITLAARE AALPVLEPAL GQQQPTPSDQ PCILFVDVPD PEQALSTEED
660 670 680 690 700
VVTLGWAETT LPMTEAQEPC SVSPEPTGPE SSSRWLDDLL ASPPPNSGSA
710 720 730 740 750
RRAAGAELKD RQSPSTCSEG LLGWAQKDLQ SEFGVATDSH HSSFGSSSWS
760 770 780 790 800
QDTSQNYSLG GRSPVGDTGL GKRDWSSKCG QGSGEGSTRE WASRHSLGQE
810 820 830 840 850
VIGIGGSQDE SEVPVRERAV GRPAQLGAQG LEADAQQWEF GKRESQDPHS
860 870 880 890 900
IHDKELQDQE FGKRDSLGSF STRDASLQDW EFGKRASVST NQDTDENDQE
910 920 930 940 950
LGMKNLSRGY SSQDAEEQDR EFEKRDSVLD IHGSRATAQQ NQEFGKSAWF
960 970 980 990 1000
QDYSSGGGGS RVLGSQERGF GIRSLSSGFS PEEAQQQDEE FEKKTPVGED
1010 1020 1030 1040 1050
RFCEASRDVG HLEEGASGGL LSPSTPHSRD GAARPKDEGS WQDGDSSQEI
1060 1070 1080 1090 1100
TRLQGRMQAE SQSPTNVDLE DKEREQRGWA GEFSLGVAAQ SEAAFSPGRQ
1110 1120 1130 1140 1150
DWSRDVCVEA SESSYQFGII GNDRVSGAGL SPSRKSGGGH FVPPGETKAG
1160 1170 1180 1190 1200
AVDWTDQLGL RNLEVSSCVS SEGPSEAREN VVGQMGWSDS LGLNNGDLAR
1210 1220 1230 1240 1250
RLGTGESEEP RSLGVGEKDW TSSVEARNRD LPGQAEVGRH SQARESGVGE
1260 1270 1280 1290 1300
PDWSGAEAGE FLKSRERGVG QADWTPDLGL RNMAPGAGCS PGEPRELGVG
1310 1320 1330 1340 1350
QVDWGDDLGL RNLEVSCDLE SGGSRGCGVG QMDWAQDLGL RNLRLCGAPS
1360 1370 1380 1390 1400
EVRECGVGRV GPDLELDPKS SGSLSPGLET EDPLEARELG VGEISGPETQ
1410 1420 1430 1440 1450
GEDSSSPSFE TPSEDTGMDT GEAPSLGASP SSCLTRSPPS GSQSLLEGIM
1460 1470 1480 1490 1500
TASSSKGAPQ RESAASGSRV LLEEEGLAAG AGQGEPQEPS RAPLPSSRPQ
1510 1520 1530 1540 1550
PDGEASQVEE VDGTWSLTGA ARQNEQASAP PPRRPPRGLL PSCPSEDFSF
1560 1570 1580 1590 1600
IEDTEILDSA MYRSRANLGR KRGHRAPAIR PGGTLGLSET ADSDTRLFQD
1610 1620 1630 1640 1650
STEPRASRVP SSDEEVVEEP QSRRTRMSLG TKGLKVNLFP GLSPSALKAK
1660 1670 1680 1690 1700
LRSRNRSAEE GEVTESKSSQ KESSVQRSKS CKVPGLGKPL TLPPKPEKSS
1710 1720
GSEGSSPNWL QALKLKKKKI
Length:1,720
Mass (Da):181,825
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7CFF0046559B923D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YJL4Z4YJL4_MOUSE
182 kDa tankyrase-1-binding protein
Tnks1bp1
1,058Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BEG9A0A571BEG9_MOUSE
182 kDa tankyrase-1-binding protein
Tnks1bp1
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAM22340 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti941N → D in BAC98246 (PubMed:14621295).Curated1
Sequence conflicti941N → D in AAH25943 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX546441 Genomic DNA Translation: CAM22340.1 Sequence problems.
AK129436 mRNA Translation: BAC98246.1
BC024499 mRNA Translation: AAH24499.1
BC025943 mRNA Translation: AAH25943.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38166.1

NCBI Reference Sequences

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RefSeqi
NP_001074729.1, NM_001081260.2
XP_017173105.1, XM_017317616.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000111605; ENSMUSP00000107232; ENSMUSG00000033955

Database of genes from NCBI RefSeq genomes

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GeneIDi
228140

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:228140

UCSC genome browser

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UCSCi
uc012byp.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX546441 Genomic DNA Translation: CAM22340.1 Sequence problems.
AK129436 mRNA Translation: BAC98246.1
BC024499 mRNA Translation: AAH24499.1
BC025943 mRNA Translation: AAH25943.1
CCDSiCCDS38166.1
RefSeqiNP_001074729.1, NM_001081260.2
XP_017173105.1, XM_017317616.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi230718, 15 interactors
IntActiP58871, 14 interactors
MINTiP58871
STRINGi10090.ENSMUSP00000107232

PTM databases

iPTMnetiP58871
PhosphoSitePlusiP58871

Proteomic databases

EPDiP58871
jPOSTiP58871
MaxQBiP58871
PaxDbiP58871
PeptideAtlasiP58871
PRIDEiP58871
ProteomicsDBi263070

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
27306, 200 antibodies

Genome annotation databases

EnsembliENSMUST00000111605; ENSMUSP00000107232; ENSMUSG00000033955
GeneIDi228140
KEGGimmu:228140
UCSCiuc012byp.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
85456
MGIiMGI:2446193, Tnks1bp1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG502QSXZ, Eukaryota
GeneTreeiENSGT00940000154184
HOGENOMiCLU_003005_0_0_1
InParanoidiP58871
OMAiWAGDFSL
OrthoDBi64879at2759
PhylomeDBiP58871
TreeFamiTF336029

Enzyme and pathway databases

ReactomeiR-MMU-429947, Deadenylation of mRNA
R-MMU-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
228140, 3 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tnks1bp1, mouse

Protein Ontology

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PROi
PR:P58871
RNActiP58871, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000033955, Expressed in stomach and 216 other tissues
ExpressionAtlasiP58871, baseline and differential
GenevisibleiP58871, MM

Family and domain databases

InterProiView protein in InterPro
IPR032764, Tankyrase-bd_C
IPR040006, TNKS1BP1-like
PANTHERiPTHR22042, PTHR22042, 1 hit
PfamiView protein in Pfam
PF15327, Tankyrase_bdg_C, 1 hit
SMARTiView protein in SMART
SM01319, Tankyrase_bdg_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTB182_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58871
Secondary accession number(s): A2BH84, Q6ZPI8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: May 29, 2007
Last modified: June 2, 2021
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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