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Protein

Gamma-tubulin complex component 3

Gene

Tubgcp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 3
Short name:
GCP-3
Gene namesi
Name:Tubgcp3
Synonyms:Gcp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2183752 Tubgcp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000781192 – 905Gamma-tubulin complex component 3Add BLAST904

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei113PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP58854
MaxQBiP58854
PaxDbiP58854
PeptideAtlasiP58854
PRIDEiP58854

PTM databases

iPTMnetiP58854
PhosphoSitePlusiP58854

Expressioni

Gene expression databases

BgeeiENSMUSG00000000759 Expressed in 273 organ(s), highest expression level in bone marrow
CleanExiMM_TUBGCP3
ExpressionAtlasiP58854 baseline and differential
GenevisibleiP58854 MM

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 (By similarity). Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBTUBGCP3 and CDK5RAP2 (By similarity). Interacts with NIN (via N-terminus); the interaction may promote recruitment of the gamma-tubulin ring complex to the centrosome (PubMed:15784680).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi234417, 15 interactors
CORUMiP58854
IntActiP58854, 12 interactors
MINTiP58854
STRINGi10090.ENSMUSP00000000776

Structurei

3D structure databases

ProteinModelPortaliP58854
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi823 – 827Poly-Glu5

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG2000 Eukaryota
ENOG410XQ5B LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000007959
HOVERGENiHBG031568
InParanoidiP58854
KOiK16570
OMAiKRCVVWT
OrthoDBiEOG091G01V2
PhylomeDBiP58854
TreeFamiTF300705

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

P58854-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPDQKSPN VLLQNLCCRI LGRSEADVAQ QFQFAVRVIG SNFAPTVERD
60 70 80 90 100
EFLVAEKIKK ELIRQRREAD AALFSELHRK LHSQGVLKNK WSILYLLLNL
110 120 130 140 150
SEDPRKQASK VTSYASLFAQ ALPRDAHSTP YYYARPQTLP LNYQDRSTQA
160 170 180 190 200
QSSGSLGSSG ISSIGMCGLS GPTPVQPFLP GQSHQAPGVG DGLRQQLGPR
210 220 230 240 250
LAWTLTGNQP SSQTPTSKGF PNALSRNLTR SRREGDPGGT LEVTEAALVR
260 270 280 290 300
DILYVFQGID GKNIKMSSTE NCYKVEAKAN LNKSLRDTAV RLAELGWLHN
310 320 330 340 350
KIRKYADQRS LDRSFGLVGQ SFCAALHQEL KEYYRLLSVL HSQLQLEDDQ
360 370 380 390 400
GVNLGLESSL TLRRLLVWTY DPKIRLKTLA ALVDHCQGRK GGELASAVHA
410 420 430 440 450
YTKTGDPYMK SLVQHILSLV SHPVLSFLYR WIYDGELEDT YHEFFVASDP
460 470 480 490 500
TVKTDRLWHD KYTLRKSMIP SFITMDQSRK VLLIGKSINF LHQVCHDQTP
510 520 530 540 550
TTKMIAVTKS AESPRDAADL FTDLENAFQG KIDAAYFETS KYLLDVLNKK
560 570 580 590 600
YSLLEHMQAM RRYLLLGQGD FIRHLMDLLK PELVRPATTL YQHNLTGILE
610 620 630 640 650
TAVRATNAQF DSPEILKRLD VRLLEVSPGD TGWDVFSLDY HVDGPIATVF
660 670 680 690 700
TRECMSHYLR VFNFLWRAKR MEYILTDIRK GHMCNAKLLR NMPEFSGVLH
710 720 730 740 750
QCHILASEMV HFIHQMQYYI TFEVLECSWD ELWNRVQQAQ DLDHIIAAHE
760 770 780 790 800
AFLNTITSRC LLDSNSRVLL NQLRAVFDQI IELQNAQDVM YRAALEELQR
810 820 830 840 850
RLQFEEKKKQ REIEGQWGVT AAEEEEENKR IREFQDSIPK MCSQLRILTH
860 870 880 890 900
FYQGVVQQFL VLLTTSSDES LQFLSFRLDF NEHYKAREPR LRVSLGSRGR

RSSHT
Length:905
Mass (Da):103,469
Last modified:October 11, 2005 - v2
Checksum:i7140808D349A471E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q0R3E9Q0R3_MOUSE
Gamma-tubulin complex component
Tubgcp3
364Annotation score:
F6QMZ4F6QMZ4_MOUSE
Gamma-tubulin complex component 3
Tubgcp3
70Annotation score:
F7AJZ3F7AJZ3_MOUSE
Gamma-tubulin complex component 3
Tubgcp3
86Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229 – 232TRSR → HASG in AAH25647 (PubMed:15489334).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150149 mRNA Translation: BAE29343.1
BC025647 mRNA Translation: AAH25647.1
BC058566 mRNA Translation: AAH58566.1
CCDSiCCDS22103.1
RefSeqiNP_932148.1, NM_198031.1
UniGeneiMm.142095
Mm.246402

Genome annotation databases

EnsembliENSMUST00000000776; ENSMUSP00000000776; ENSMUSG00000000759
GeneIDi259279
KEGGimmu:259279
UCSCiuc009kwd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150149 mRNA Translation: BAE29343.1
BC025647 mRNA Translation: AAH25647.1
BC058566 mRNA Translation: AAH58566.1
CCDSiCCDS22103.1
RefSeqiNP_932148.1, NM_198031.1
UniGeneiMm.142095
Mm.246402

3D structure databases

ProteinModelPortaliP58854
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234417, 15 interactors
CORUMiP58854
IntActiP58854, 12 interactors
MINTiP58854
STRINGi10090.ENSMUSP00000000776

PTM databases

iPTMnetiP58854
PhosphoSitePlusiP58854

Proteomic databases

EPDiP58854
MaxQBiP58854
PaxDbiP58854
PeptideAtlasiP58854
PRIDEiP58854

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000776; ENSMUSP00000000776; ENSMUSG00000000759
GeneIDi259279
KEGGimmu:259279
UCSCiuc009kwd.1 mouse

Organism-specific databases

CTDi10426
MGIiMGI:2183752 Tubgcp3

Phylogenomic databases

eggNOGiKOG2000 Eukaryota
ENOG410XQ5B LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000007959
HOVERGENiHBG031568
InParanoidiP58854
KOiK16570
OMAiKRCVVWT
OrthoDBiEOG091G01V2
PhylomeDBiP58854
TreeFamiTF300705

Enzyme and pathway databases

ReactomeiR-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

ChiTaRSiTubgcp3 mouse
PROiPR:P58854
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000759 Expressed in 273 organ(s), highest expression level in bone marrow
CleanExiMM_TUBGCP3
ExpressionAtlasiP58854 baseline and differential
GenevisibleiP58854 MM

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCP3_MOUSE
AccessioniPrimary (citable) accession number: P58854
Secondary accession number(s): Q6PDQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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