Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Textile convulsant peptide

Gene
N/A
Organism
Conus textile (Cloth-of-gold cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Causes convulsions mice.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Textile convulsant peptide1 Publication
Short name:
TCP1 Publication
OrganismiConus textile (Cloth-of-gold cone)
Taxonomic identifieri6494 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusCylinder

Organism-specific databases

ConoServeri1810 Textile convulsant peptide

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444871 – 23Textile convulsant peptide1 PublicationAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 10By similarity
Disulfide bondi5 ↔ 15By similarity
Disulfide bondi9 ↔ 20By similarity
Modified residuei23Proline amide; partial3 Publications1

Post-translational modificationi

The C-terminal amidation is described in Ref. 1 and PubMed:23031820, but not in PubMed:22709442.Curated

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct. Is present in all duct parts with a highest content in part 2 (proximal of the venom bulb) and then decreases in concentration toward the end of the duct.2 Publications

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.Curated
The cysteine framework is VI/VII (C-C-CC-C-C).By similarity

Keywords - Domaini

Knottin

Sequencei

Sequence statusi: Complete.

P58845-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
NCPYCVVYCC PPAYCEASGC RPP
Length:23
Mass (Da):2,496
Last modified:June 6, 2002 - v1
Checksum:iAE99BDBB7DC8AD56
GO

Sequence databases

PIRiA59048

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA59048

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1810 Textile convulsant peptide

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiU6TC_CONTE
AccessioniPrimary (citable) accession number: P58845
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: October 10, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again