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Protein

Conotoxin QcVIA

Gene
N/A
Organism
Conus quercinus (Oak cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Causes scratching and restlessness in mice.

Miscellaneous

The order of the last three amino acids has not yet been definitively established.

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin QcVIA
OrganismiConus quercinus (Oak cone)
Taxonomic identifieri101313 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusLividoconus

Organism-specific databases

ConoServeri1512 QcVIA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444861 – 25Conotoxin QcVIAAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 12By similarity
Modified residuei54-hydroxyproline1 Publication1
Disulfide bondi7 ↔ 17By similarity
Disulfide bondi11 ↔ 22By similarity

Keywords - PTMi

Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.Curated
The cysteine framework is VI/VII (C-C-CC-C-C).

Keywords - Domaini

Knottin

Sequencei

Sequence statusi: Complete.

P58843-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
DQSCPWCGFT CCLPNYCQGL TCTVI
Length:25
Mass (Da):2,756
Last modified:June 6, 2002 - v1
Checksum:iC5327C927FC62D55
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence uncertaintyi23 – 253

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1512 QcVIA

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiU6AA_CONQU
AccessioniPrimary (citable) accession number: P58843
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: October 10, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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