UniProtKB - P58807 (CTA6A_CONMR)
Protein
Chi-conotoxin CMrVIA
Gene
N/A
Organism
Conus marmoreus (Marble cone)
Status
Functioni
Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2).By similarity
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Chi-conotoxin CMrVIAAlternative name(s): Conotoxin CMrVIA Lambda-conotoxin CMrVIA |
Organismi | Conus marmoreus (Marble cone) |
Taxonomic identifieri | 42752 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Conus › Conus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000044507 | 1 – 11 | Chi-conotoxin CMrVIA1 PublicationAdd BLAST | 11 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 2 ↔ 11 | 1 PublicationImported | ||
Disulfide bondi | 3 ↔ 8 | 1 PublicationImported | ||
Modified residuei | 10 | 4-hydroxyproline2 Publications | 1 |
Keywords - PTMi
Disulfide bond, HydroxylationExpressioni
Tissue specificityi
Expressed by the venom duct.1 Publication
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2B5P | NMR | - | A | 1-11 | [»] | |
2B5Q | NMR | - | A | 1-11 | [»] | |
SMRi | P58807 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P58807 |
Family & Domainsi
Domaini
The cysteine framework is X (CC-CX[hydroxyPro]C).Curated
Sequence similaritiesi
Belongs to the conotoxin T superfamily.Curated
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Similar proteinsi
Cross-referencesi
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2B5P | NMR | - | A | 1-11 | [»] | |
2B5Q | NMR | - | A | 1-11 | [»] | |
SMRi | P58807 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Miscellaneous databases
EvolutionaryTracei | P58807 |
Family and domain databases
ProtoNeti | Search... |
Entry informationi
Entry namei | CTA6A_CONMR | |
Accessioni | P58807Primary (citable) accession number: P58807 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | May 2, 2002 | |
Last modified: | September 12, 2018 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references