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Protein

Bromosleeper peptide

Gene
N/A
Organism
Conus radiatus (Rayed cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces sleep-like symptoms in mice of all ages.

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Bromosleeper peptide
OrganismiConus radiatus (Rayed cone)
Taxonomic identifieri61198 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPhasmoconus

Organism-specific databases

ConoServeri1811 Bromosleeper peptide

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000448801 – 33Bromosleeper peptideAdd BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16'-bromotryptophan1 Publication1
Modified residuei64-carboxyglutamate1 Publication1
Disulfide bondi7 ↔ 19By similarity
Modified residuei84-carboxyglutamate1 Publication1
Modified residuei94-carboxyglutamate1 Publication1
Disulfide bondi11 ↔ 27By similarity
Disulfide bondi18 ↔ 31By similarity
Modified residuei214-hydroxyproline1 Publication1
Modified residuei224-hydroxyproline1 Publication1
Modified residuei294-carboxyglutamate1 Publication1

Keywords - PTMi

Bromination, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.Curated
The cysteine framework is VI/VII (C-C-CC-C-C).

Keywords - Domaini

Knottin

Sequencei

Sequence statusi: Complete.

P58804-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
WATIDECEET CNVTFKTCCG PPGDWQCVEA CPV
Length:33
Mass (Da):3,636
Last modified:May 2, 2002 - v1
Checksum:i8AF54168A0554EDF
GO

Mass spectrometryi

Molecular mass is 3916.4 Da from positions 1 - 33. Determined by LSI. 1 Publication

Sequence databases

PIRiB58512

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiB58512

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1811 Bromosleeper peptide

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiU6BW_CONRA
AccessioniPrimary (citable) accession number: P58804
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: October 10, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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