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Protein

TBC1 domain family member 10A

Gene

Tbc1d10a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as GTPase-activating protein for RAB27A.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei156Arginine fingerBy similarity1
Sitei197Glutamine fingerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-MMU-8854214 TBC/RABGAPs

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 10A
Alternative name(s):
EBP50-PDX interactor of 64 kDa
Short name:
EPI64 protein
Gene namesi
Name:Tbc1d10a
Synonyms:Epi64, Tbc1d10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144164 Tbc1d10a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002080361 – 500TBC1 domain family member 10AAdd BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39PhosphoserineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei407PhosphoserineBy similarity1
Modified residuei477PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP58802
MaxQBiP58802
PaxDbiP58802
PeptideAtlasiP58802
PRIDEiP58802

PTM databases

iPTMnetiP58802
PhosphoSitePlusiP58802

Expressioni

Tissue specificityi

Expressed in most tissues, except for skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000034412 Expressed in 233 organ(s), highest expression level in submandibular gland
CleanExiMM_TBC1D10A
ExpressionAtlasiP58802 baseline and differential
GenevisibleiP58802 MM

Interactioni

Subunit structurei

Binds to the first PDZ domain of SLC9A3R1 and SLC9A3R2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136453

Structurei

3D structure databases

ProteinModelPortaliP58802
SMRiP58802
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 299Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni497 – 500Binding to the PDZ domain of EBP50By similarity4

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Phylogenomic databases

eggNOGiKOG2221 Eukaryota
ENOG410XPSR LUCA
GeneTreeiENSGT00920000148983
HOVERGENiHBG070028
InParanoidiP58802
KOiK19944

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P58802-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKSSRENGP REPAAGGSLS GTRESLAQGP DAATADELSS LGSDSEANGF
60 70 80 90 100
AERRIDKFGF IVGSQGAEGA LEEVPLEVLR QRESKWLDML NNWDKWMAKK
110 120 130 140 150
HKKIRLRCQK GIPPSLRGRA WQYLSGGKVK LQQNPGKFDE LDMSPGDPKW
160 170 180 190 200
LDVIERDLHR QFPFHEMFVS RGGHGQQDLF RVLKAYTLYR PEEGYCQAQA
210 220 230 240 250
PIAAVLLMHM PAEQAFWCLV QVCEKYLPGY YSEKLEAIQL DGEILFSLLQ
260 270 280 290 300
KVSPVAHKHL SRQKIDPLLY MTEWFMCAFA RTLPWSSVLR VWDMFFCEGV
310 320 330 340 350
KIIFRVGLVL LKHALGSPEK LKACQGQYET IEQLRSLSPK IMQEAFLVQE
360 370 380 390 400
VIELPVTERQ IEREHLIQLR RWQETRGELE CRSLPRMHGA KAILDAEPGP
410 420 430 440 450
RPALQPSPSI RLPPDAALLS SKAKPHKQAQ KEQKRTKTSA QLDKSPGLSQ
460 470 480 490 500
ATVVTAAGDA CPPQGVSPKD PVPQDPTPQN LACHHSQESL TSQESEDTYL
Length:500
Mass (Da):56,202
Last modified:May 2, 2002 - v1
Checksum:i15954DB7A4E3A9B6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SPX8Q5SPX8_MOUSE
TBC1 domain family member 10A
Tbc1d10a
534Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018300 mRNA Translation: AAH18300.1
CCDSiCCDS56756.1
RefSeqiNP_598784.1, NM_134023.1
UniGeneiMm.28140

Genome annotation databases

EnsembliENSMUST00000180088; ENSMUSP00000136453; ENSMUSG00000034412
GeneIDi103724
KEGGimmu:103724
UCSCiuc007huq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018300 mRNA Translation: AAH18300.1
CCDSiCCDS56756.1
RefSeqiNP_598784.1, NM_134023.1
UniGeneiMm.28140

3D structure databases

ProteinModelPortaliP58802
SMRiP58802
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136453

PTM databases

iPTMnetiP58802
PhosphoSitePlusiP58802

Proteomic databases

EPDiP58802
MaxQBiP58802
PaxDbiP58802
PeptideAtlasiP58802
PRIDEiP58802

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180088; ENSMUSP00000136453; ENSMUSG00000034412
GeneIDi103724
KEGGimmu:103724
UCSCiuc007huq.1 mouse

Organism-specific databases

CTDi83874
MGIiMGI:2144164 Tbc1d10a

Phylogenomic databases

eggNOGiKOG2221 Eukaryota
ENOG410XPSR LUCA
GeneTreeiENSGT00920000148983
HOVERGENiHBG070028
InParanoidiP58802
KOiK19944

Enzyme and pathway databases

ReactomeiR-MMU-8854214 TBC/RABGAPs

Miscellaneous databases

ChiTaRSiTbc1d10a mouse
PROiPR:P58802
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034412 Expressed in 233 organ(s), highest expression level in submandibular gland
CleanExiMM_TBC1D10A
ExpressionAtlasiP58802 baseline and differential
GenevisibleiP58802 MM

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTB10A_MOUSE
AccessioniPrimary (citable) accession number: P58802
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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