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Entry version 141 (18 Sep 2019)
Sequence version 1 (27 Mar 2002)
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Protein

Reelin

Gene

Reln

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2062Zinc 1By similarity1
Metal bindingi2075Zinc 1By similarity1
Metal bindingi2180Zinc 1By similarity1
Metal bindingi2265Zinc 1By similarity1
Metal bindingi2398Zinc 2By similarity1
Metal bindingi2400Zinc 2By similarity1
Metal bindingi2461Zinc 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protease, Serine protease
Biological processCell adhesion
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-8866376 Reelin signalling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reelin (EC:3.4.21.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Reln
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
3553 Reln

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Reln are the cause of the creeping phenotype, which is characterized by tremor, gait ataxia, cerebellar hypoplasia and abnormal neuronal migration (particularly in the cerebral cortex and hippocampus). The mutation is due to a nucleotide insertion at codon 1892 which results in a translational frameshift and truncation of the protein.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003030628 – 3462ReelinAdd BLAST3435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 128PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 180PROSITE-ProRule annotation
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi541 ↔ 582PROSITE-ProRule annotation
Disulfide bondi610 ↔ 615PROSITE-ProRule annotation
Glycosylationi630N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi676 ↔ 686PROSITE-ProRule annotation
Disulfide bondi693 ↔ 702PROSITE-ProRule annotation
Disulfide bondi896 ↔ 938PROSITE-ProRule annotation
Disulfide bondi969 ↔ 976PROSITE-ProRule annotation
Disulfide bondi1035 ↔ 1045PROSITE-ProRule annotation
Disulfide bondi1052 ↔ 1061PROSITE-ProRule annotation
Glycosylationi1268N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1272 ↔ 1311PROSITE-ProRule annotation
Disulfide bondi1340 ↔ 1349PROSITE-ProRule annotation
Glycosylationi1448N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1601N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1634 ↔ 1674PROSITE-ProRule annotation
Disulfide bondi1703 ↔ 1710PROSITE-ProRule annotation
Glycosylationi1751N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1922N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2102InterchainPROSITE-ProRule annotation
Disulfide bondi2134 ↔ 2144PROSITE-ProRule annotation
Disulfide bondi2138 ↔ 2150PROSITE-ProRule annotation
Glycosylationi2146N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2152 ↔ 2161PROSITE-ProRule annotation
Disulfide bondi2196 ↔ 2236PROSITE-ProRule annotation
Glycosylationi2270N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2318N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2349 ↔ 2388PROSITE-ProRule annotation
Disulfide bondi2394 ↔ 2560PROSITE-ProRule annotation
Disulfide bondi2483 ↔ 2493PROSITE-ProRule annotation
Disulfide bondi2487 ↔ 2498PROSITE-ProRule annotation
Disulfide bondi2500 ↔ 2509PROSITE-ProRule annotation
Disulfide bondi2545 ↔ 2585PROSITE-ProRule annotation
Glycosylationi2570N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2795 ↔ 2802PROSITE-ProRule annotation
Disulfide bondi2920 ↔ 2967PROSITE-ProRule annotation
Glycosylationi2963N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3017N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3074N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3161 ↔ 3171PROSITE-ProRule annotation
Glycosylationi3186N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3233 ↔ 3243PROSITE-ProRule annotation
Disulfide bondi3237 ↔ 3249PROSITE-ProRule annotation
Disulfide bondi3251 ↔ 3260PROSITE-ProRule annotation
Disulfide bondi3297 ↔ 3347PROSITE-ProRule annotation
Glycosylationi3413N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3440N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P58751

PRoteomics IDEntifications database

More...
PRIDEi
P58751

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P58751

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P58751

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
246846, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000058574

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P58751

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 192ReelinPROSITE-ProRule annotationAdd BLAST165
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati594 – 605BNR 1Add BLAST12
Domaini672 – 703EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Repeati800 – 811BNR 2Add BLAST12
Repeati953 – 964BNR 3Add BLAST12
Domaini1031 – 1062EGF-like 2PROSITE-ProRule annotationAdd BLAST32
Repeati1158 – 1169BNR 4Add BLAST12
Repeati1324 – 1335BNR 5Add BLAST12
Domaini1410 – 1443EGF-like 3PROSITE-ProRule annotationAdd BLAST34
Repeati1536 – 1547BNR 6Add BLAST12
Repeati1687 – 1698BNR 7Add BLAST12
Domaini1766 – 1797EGF-like 4PROSITE-ProRule annotationAdd BLAST32
Repeati1885 – 1896BNR 8Add BLAST12
Repeati2044 – 2055BNR 9Add BLAST12
Domaini2130 – 2162EGF-like 5PROSITE-ProRule annotationAdd BLAST33
Repeati2251 – 2262BNR 10Add BLAST12
Repeati2400 – 2411BNR 11Add BLAST12
Domaini2479 – 2510EGF-like 6PROSITE-ProRule annotationAdd BLAST32
Repeati2599 – 2610BNR 12Add BLAST12
Repeati2779 – 2790BNR 13Add BLAST12
Domaini2854 – 2885EGF-like 7PROSITE-ProRule annotationAdd BLAST32
Repeati2980 – 2991BNR 14Add BLAST12
Repeati3144 – 3156BNR 15Add BLAST13
Domaini3229 – 3261EGF-like 8PROSITE-ProRule annotationAdd BLAST33
Repeati3364 – 3375BNR 16Add BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3433 – 3462Arg-rich (basic)Add BLAST30

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The basic C-terminal region is essential for secretion.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the reelin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEXI Eukaryota
ENOG410XQKB LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252908

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P58751

KEGG Orthology (KO)

More...
KOi
K06249

Database of Orthologous Groups

More...
OrthoDBi
9177at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P58751

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08544 Reeler, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 19 hits
2.60.40.4060, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR008979 Galactose-bd-like_sf
IPR002861 Reeler_dom
IPR042307 Reeler_sf
IPR034968 Reelin
IPR036278 Sialidase_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11841 PTHR11841, 8 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02014 Reeler, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50939 SSF50939, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 6 hits
PS50026 EGF_3, 5 hits
PS51019 REELIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P58751-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERGCWAPRT LVLAVLLLLL ATLRARAATG YYPRFSPFFF LCTHHGELEG
60 70 80 90 100
DGEQGEVLIS LHIAGNPTYY VPGQEYHVTI STSTFFDGLL VTGLYTSTSI
110 120 130 140 150
QSSQSIGGSS AFGFGIMSDH QFGNQFMCSV VASHVSHLPT TNLSFVWIAP
160 170 180 190 200
PAGTGCVNFM ATATHRGQVI FKDALAQQLC EQGAPTEATA YSHLAEIHSD
210 220 230 240 250
SVILRDDFDS YHQLELNPNI WAECSNCDTG EQCGTIMHGN AVTFCEPYGP
260 270 280 290 300
RELTTTYLNT TTASVLQFSI GSGSCRFSYS DPSIIVSYAK NNTADWIQLE
310 320 330 340 350
KIRAPSNVST IIHILYLPED AKGENVQFQW KQDSLHVGEV YEACWALDNI
360 370 380 390 400
LVINSAHRQV ILEDSLDPVD TGNWLFFPGA TVKHSCQSDG NAIYFHGNEG
410 420 430 440 450
SQLNFATTRD VDLSTEDIQE QWSEEFESQP TGWDILGAVV GSECGTIESG
460 470 480 490 500
LSLVFLKDGE RKLCTPYMDT TGYGNLRFYF AMGGTCDPGD SHENDVILYA
510 520 530 540 550
KIEGKKEHIA LDTLSYSSYK VPTLVSVVIN PELQTPATKF CLRQKNHQGH
560 570 580 590 600
NQNVWAVDFF HVLPILPSTM SHMIQFSINL GCGTHQPGNS VSLEFSTNHG
610 620 630 640 650
RSWSLLHTEC LPEICAGPHL PHSTIYSSEN YSGWNRVTIP LPNAALTRDT
660 670 680 690 700
RIRWRQTGPI LGNMWAIDNV YIGPSCLKFC SGRGQCTRHG CKCDPGFSGP
710 720 730 740 750
ACEMASQTFP MFISESFGSS RLSSYHNFYS IRGAEVSFGC GVLASGKALV
760 770 780 790 800
FNKDGRRQLI TSFLDSSQSR FLQFTLRLGS KSVLSTCRAP DQPGEGVLLH
810 820 830 840 850
YSYDNGITWK LLEHYSYLNY HEPRIISVEL PDDAKQFGIQ FRWWQPYHSS
860 870 880 890 900
QGEDVWAIDE ILMTSVLFNS ISLDFTNLVE VTQSLGFYLG NIQPYCGHDW
910 920 930 940 950
TLCFTGDSKL ASSMRYVETQ SMQIGASYMI QFSLVMGCGQ KYTPHMDNQV
960 970 980 990 1000
KLEYSTNHGL TWHLVQDECL PSMPSCQEFT SASIYHASEF TQWRRVTVIL
1010 1020 1030 1040 1050
PQKTWSGATR FRWSQSYYTA QDEWALDDIY IGQQCPNMCS GHGSCDHGVC
1060 1070 1080 1090 1100
RCDQGYQGTE CHPEAALPST IMSDFENPSS WDSDWQEVIG GEVVKPEQGC
1110 1120 1130 1140 1150
GVVSSGSSLY FSKAGKRQLV SWDLDTSWVD FVQFYIQIGG ESAACNKPDS
1160 1170 1180 1190 1200
REEGVLLQYS NNGGIQWHLL AEMYFSDFGK PRFVYLELPA AAKTPCTRFR
1210 1220 1230 1240 1250
WWQPVFSGED YDQWAVDDII ILSEKQKQVI PVVNPTLPQN FYEKPAFDYP
1260 1270 1280 1290 1300
INQMSVWLML ANEGMAKNDS FCATTPSAMV FGKSDGDRFA VTRDLTLKPG
1310 1320 1330 1340 1350
YVLQFKLNIG CASQFSSTAP VLLQYSHDAG MSWFLVKEGC FPASAGKGCE
1360 1370 1380 1390 1400
GNSRELSEPT VYYTGDFEEW TRVTIAIPRS LASSKTRFRW IQESSSQKNV
1410 1420 1430 1440 1450
PPFGLDGVYI SEPCPSYCSG HGDCISGVCF CDLGYTAAQG TCVSNIPNHS
1460 1470 1480 1490 1500
EMFDRFEGKL SPLWYKISGG QVGTGCGTLS DGRSLYFNGL GKREARTVPL
1510 1520 1530 1540 1550
DTRNIRLVQF YIQIGSKTSG ITCIKPRARN EGLVVQYSND NGILWHLLRE
1560 1570 1580 1590 1600
LDFLSFLEPQ IISIDLPREA KTPATAFRWW QPQHGKHSAQ WALDDVLIGV
1610 1620 1630 1640 1650
NDSSQTGFQD KFDGSIDLQA NWYRIQGGQV DIDCLSMDTA LIFTENIGKP
1660 1670 1680 1690 1700
RYAETWDFHV SASSFLQFDM SMGCSKPFSA THSVQLQYSL NNGKDWHPVT
1710 1720 1730 1740 1750
EECVPPTIGC VHYTESSTYT SERFQNWRRV TVYLPLATNS PRTRFRWIQA
1760 1770 1780 1790 1800
NYTMGADAWA IDNVLLASGC PWLCSGRGIC DSGRCVCDRG FGGPFCVPVV
1810 1820 1830 1840 1850
PLPSILKDDF NGNLHPDLWP EVYGAERGNL NGETIKSGTS LIFKGEGLRM
1860 1870 1880 1890 1900
LISRDLDCTN TMYVQFSLRF IAKGTPERSH SILLQSSING GVTWRLMDEF
1910 1920 1930 1940 1950
YFPQTTSILF INVPLPYSAQ TNATRFRLWQ PYNNGKKEEI WIIDDFIIDG
1960 1970 1980 1990 2000
DNLNNPVMLL DTFDFGPRED NWFFYPGGNI GLYCPYSSKG APEEDSAMVF
2010 2020 2030 2040 2050
VSNEIGEHSI TTRDLSVNEN TIIQFEINVG CSTDSSSADP VRLEFSRDFG
2060 2070 2080 2090 2100
ATWHLLLPLC YHSSSLVSSL CSTEHHPSST YYAGTTQGWR REVVHFGKLH
2110 2120 2130 2140 2150
LCGSVRFRWY QGFYPAGSQP VTWAIDNVYI GPQCEEMCCG HGSCVNGTKC
2160 2170 2180 2190 2200
ICDPGYSGPT CKISTKNPDF LKDDFEGQLE SDRFLLMSGG KPSRKCGILS
2210 2220 2230 2240 2250
SGNNLFFNED GLRMLVTRDL DLSHARFVQF FMRLGCGKGV PDPRSQPVLL
2260 2270 2280 2290 2300
QYSLNGGLSW SLLQEFLFSN SSNVGRYIAL EMPLKARSGS TRLRWWQPSE
2310 2320 2330 2340 2350
NGHFYSPWVI DQILIGGNIS GNTVLEDDFS TLDSRKWLLH PGGTKMPVCG
2360 2370 2380 2390 2400
STGDALVFIE KASTRYVVTT DIAVNEDSFL QIDFAASCSV TDSCYAIELE
2410 2420 2430 2440 2450
YSVDLGLSWH PLVRDCLPTN VECSRYHLQR ILVSDTFNKW TRITLPLPAY
2460 2470 2480 2490 2500
TRSQATRFRW HQPAPFDKQQ TWAIDNVYIG DGCLDMCSGH GRCIQGSCVC
2510 2520 2530 2540 2550
DEQWGGLYCD EPETSLPTQL KDNFNRAPSN QNWLTVNGGK LSTVCGAVAS
2560 2570 2580 2590 2600
GLALHFSGGC SRLLVTVDLN LTNAEFIQFY FMYGCLITPS NRNQGVLLEY
2610 2620 2630 2640 2650
SVNGGITWTL LMEIFYDQYS KPGFVNILLP PDAKEIGTRF RWWQPRHDGL
2660 2670 2680 2690 2700
DQNDWAIDNV LISGSADQRT VMLDTFSSAP VPQHERSPAD AGPVGRIAFD
2710 2720 2730 2740 2750
MFMEDKTSVN ENWVFHDDCT VERFCDSPDG VMLCGSHDGR EVYAVTHDLT
2760 2770 2780 2790 2800
PTENWIMQFK ISVGCKVPEK IAQNQIHVQF STDFGVSWSY LVPQCLPADP
2810 2820 2830 2840 2850
KCSGTVSQPS VFFPTKGWKR ITYPLPESLM GNPVRFRFYQ KYSDVQWAID
2860 2870 2880 2890 2900
NFYLGPGCLD NCGGHGDCLK EQCICDPGYS GPHCYLTHTL KTFLKERFDS
2910 2920 2930 2940 2950
EEIKPDLWMS LEGGSTCTEC GILAENTALY FGGSTVRQAI TQDLDLRGAK
2960 2970 2980 2990 3000
FLQYWGRIGS ENNMTSCHRP VCRKEGVLLD YSKDGGITWT LLHEMDFQKY
3010 3020 3030 3040 3050
ISVRHDYILL PEGALTNTTR LRWWQPFVIS NGLVVSGVER AQWALDNILI
3060 3070 3080 3090 3100
GGAEINPSQL VDTFDDEGSS HEENWSFYPN AVRTAGFCGN PSFHLYWPNK
3110 3120 3130 3140 3150
KKDKTHNALS SRELIIQPGY MMQFKIVVGC EATSCGDLHS VMLEYTKDAR
3160 3170 3180 3190 3200
SDSWQLVQTQ CLPSSSNSIG CSPFQFHEAT IYNAVNSSSW KRITIQLPDH
3210 3220 3230 3240 3250
VSSSATQFRW IQKGEETEKQ SWAIDHVYIG EACPRLCSGH GYCTTGAVCI
3260 3270 3280 3290 3300
CDESFQGDDC SVFSHELPSY IKDNFESARV TEANWETIQG GAIGSGCGQL
3310 3320 3330 3340 3350
APYAHGDSLY FNGCQIRQAA TKPLDLTRAS KIMFVLQIGS TAQTDSCNSD
3360 3370 3380 3390 3400
LSGPHTVDKA VLLQYSVNNG ITWHVIAQHQ PKDFTQAQRV SYNVPLEARM
3410 3420 3430 3440 3450
KGVLLRWWQP RHNGTGHDQW ALDHVEVVLV STRKQNYMMN FSRQHGLRHF
3460
YNRRRRSLRR YP
Length:3,462
Mass (Da):387,531
Last modified:March 27, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCCF89B090E035F6
GO
Isoform 2 (identifier: P58751-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3430-3431: Missing.

Show »
Length:3,460
Mass (Da):387,345
Checksum:i610A71EBC643226D
GO
Isoform 3 (identifier: P58751-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3430-3462: Missing.

Show »
Length:3,429
Mass (Da):383,236
Checksum:i22F3FFBBDF2E088B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LZI7F1LZI7_RAT
Reelin
Reln
3,462Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LM29F1LM29_RAT
Reelin
Reln
3,461Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti336H → R in BAC75467 (PubMed:12670697).Curated1
Sequence conflicti2714V → L in BAC75467 (PubMed:12670697).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0055803430 – 3462Missing in isoform 3. CuratedAdd BLAST33
Alternative sequenceiVSP_0055793430 – 3431Missing in isoform 2. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB049473 mRNA Translation: BAB78470.1
AB062680 mRNA Translation: BAC75467.1

NCBI Reference Sequences

More...
RefSeqi
NP_536319.2, NM_080394.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24718

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:24718

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049473 mRNA Translation: BAB78470.1
AB062680 mRNA Translation: BAC75467.1
RefSeqiNP_536319.2, NM_080394.2

3D structure databases

SMRiP58751
ModBaseiSearch...

Protein-protein interaction databases

BioGridi246846, 1 interactor
STRINGi10116.ENSRNOP00000058574

PTM databases

iPTMnetiP58751
PhosphoSitePlusiP58751

Proteomic databases

PaxDbiP58751
PRIDEiP58751

Genome annotation databases

GeneIDi24718
KEGGirno:24718

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5649
RGDi3553 Reln

Phylogenomic databases

eggNOGiENOG410IEXI Eukaryota
ENOG410XQKB LUCA
HOGENOMiHOG000252908
InParanoidiP58751
KOiK06249
OrthoDBi9177at2759
PhylomeDBiP58751

Enzyme and pathway databases

ReactomeiR-RNO-8866376 Reelin signalling pathway

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P58751

Family and domain databases

CDDicd08544 Reeler, 1 hit
Gene3Di2.60.120.260, 19 hits
2.60.40.4060, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR008979 Galactose-bd-like_sf
IPR002861 Reeler_dom
IPR042307 Reeler_sf
IPR034968 Reelin
IPR036278 Sialidase_sf
PANTHERiPTHR11841 PTHR11841, 8 hits
PfamiView protein in Pfam
PF02014 Reeler, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SUPFAMiSSF50939 SSF50939, 4 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 6 hits
PS50026 EGF_3, 5 hits
PS51019 REELIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRELN_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58751
Secondary accession number(s): Q80T65
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: September 18, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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