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Protein

Prestin

Gene

SLC26A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processCell shape, Hearing

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.53.2.19 the sulfate permease (sulp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prestin
Alternative name(s):
Solute carrier family 26 member 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC26A5
Synonyms:PRES
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170615.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9359 SLC26A5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604943 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P58743

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 79CytoplasmicSequence analysisAdd BLAST79
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei80 – 100Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini101 – 102ExtracellularSequence analysis2
Transmembranei103 – 123Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini124 – 131CytoplasmicSequence analysis8
Transmembranei132 – 152Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini153 – 183ExtracellularSequence analysisAdd BLAST31
Transmembranei184 – 204Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini205 – 211CytoplasmicSequence analysis7
Transmembranei212 – 232Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini233 – 253ExtracellularSequence analysisAdd BLAST21
Transmembranei254 – 274Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini275 – 286CytoplasmicSequence analysisAdd BLAST12
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 334ExtracellularSequence analysisAdd BLAST27
Transmembranei335 – 355Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini356 – 374CytoplasmicSequence analysisAdd BLAST19
Transmembranei375 – 395Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini396 – 411ExtracellularSequence analysisAdd BLAST16
Transmembranei412 – 432Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini433 – 441CytoplasmicSequence analysis9
Transmembranei442 – 462Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini463 – 479ExtracellularSequence analysisAdd BLAST17
Transmembranei480 – 500Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini501 – 744CytoplasmicSequence analysisAdd BLAST244

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal recessive, 61 (DFNB61)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:613865

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
375611

MalaCards human disease database

More...
MalaCardsi
SLC26A5
MIMi613865 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000170615

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33731

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC26A5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20139418

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000801671 – 744PrestinAdd BLAST744

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P58743

PeptideAtlas

More...
PeptideAtlasi
P58743

PRoteomics IDEntifications database

More...
PRIDEi
P58743

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57096
57097 [P58743-2]
57098 [P58743-3]
57099 [P58743-4]
57100 [P58743-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P58743

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P58743

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170615 Expressed in 71 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC26A5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P58743 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
P58743, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000304783

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P58743

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P58743

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini525 – 713STASPROSITE-ProRule annotationAdd BLAST189

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0236 Eukaryota
COG0659 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153858

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006546

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000639

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P58743

KEGG Orthology (KO)

More...
KOi
K14703

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P58743

TreeFam database of animal gene trees

More...
TreeFami
TF313784

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030282 Prestin
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR002645 STAS_dom
IPR036513 STAS_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11814 PTHR11814, 1 hit
PTHR11814:SF32 PTHR11814:SF32, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52091 SSF52091, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00815 sulP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P58743-1) [UniParc]FASTAAdd to basket
Also known as: SLC26A5a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDHAEENEIL AATQRYYVER PIFSHPVLQE RLHTKDKVPD SIADKLKQAF
60 70 80 90 100
TCTPKKIRNI IYMFLPITKW LPAYKFKEYV LGDLVSGIST GVLQLPQGLA
110 120 130 140 150
FAMLAAVPPI FGLYSSFYPV IMYCFLGTSR HISIGPFAVI SLMIGGVAVR
160 170 180 190 200
LVPDDIVIPG GVNATNGTEA RDALRVKVAM SVTLLSGIIQ FCLGVCRFGF
210 220 230 240 250
VAIYLTEPLV RGFTTAAAVH VFTSMLKYLF GVKTKRYSGI FSVVYSTVAV
260 270 280 290 300
LQNVKNLNVC SLGVGLMVFG LLLGGKEFNE RFKEKLPAPI PLEFFAVVMG
310 320 330 340 350
TGISAGFNLK ESYNVDVVGT LPLGLLPPAN PDTSLFHLVY VDAIAIAIVG
360 370 380 390 400
FSVTISMAKT LANKHGYQVD GNQELIALGL CNSIGSLFQT FSISCSLSRS
410 420 430 440 450
LVQEGTGGKT QLAGCLASLM ILLVILATGF LFESLPQAVL SAIVIVNLKG
460 470 480 490 500
MFMQFSDLPF FWRTSKIELT IWLTTFVSSL FLGLDYGLIT AVIIALLTVI
510 520 530 540 550
YRTQSPSYKV LGKLPETDVY IDIDAYEEVK EIPGIKIFQI NAPIYYANSD
560 570 580 590 600
LYSNALKRKT GVNPAVIMGA RRKAMRKYAK EVGNANMANA TVVKADAEVD
610 620 630 640 650
GEDATKPEEE DGEVKYPPIV IKSTFPEEMQ RFMPPGDNVH TVILDFTQVN
660 670 680 690 700
FIDSVGVKTL AGIVKEYGDV GIYVYLAGCS AQVVNDLTRN RFFENPALWE
710 720 730 740
LLFHSIHDAV LGSQLREALA EQEASAPPSQ EDLEPNATPA TPEA
Length:744
Mass (Da):81,264
Last modified:March 27, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E64BE6DB2DC065E
GO
Isoform 2 (identifier: P58743-2) [UniParc]FASTAAdd to basket
Also known as: SLC26A5b

The sequence of this isoform differs from the canonical sequence as follows:
     682-685: QVVN → FIQR
     686-744: Missing.

Show »
Length:685
Mass (Da):74,844
Checksum:iEF5682F6B068BEAE
GO
Isoform 3 (identifier: P58743-3) [UniParc]FASTAAdd to basket
Also known as: SLC26A5c

The sequence of this isoform differs from the canonical sequence as follows:
     506-516: PSYKVLGKLPE → FHTEMTRRWRP
     517-744: Missing.

Show »
Length:516
Mass (Da):56,458
Checksum:iB12E4F7437574ED6
GO
Isoform 4 (identifier: P58743-4) [UniParc]FASTAAdd to basket
Also known as: SLC26A5d

The sequence of this isoform differs from the canonical sequence as follows:
     325-335: LLPPANPDTSL → FHTEMTRRWRP
     336-744: Missing.

Show »
Length:335
Mass (Da):36,949
Checksum:i49BD1BF137784071
GO
Isoform 5 (identifier: P58743-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-469: Missing.

Note: No experimental confirmation available.
Show »
Length:712
Mass (Da):77,579
Checksum:iDFC2F97FD6F18EC1
GO
Isoform 6 (identifier: P58743-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-469: Missing.
     595-595: A → ATQ

Show »
Length:714
Mass (Da):77,809
Checksum:i0D1EB01E3E0578A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z7F4Q7Z7F4_HUMAN
Prestin
SLC26A5 PRES
746Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PCM2E9PCM2_HUMAN
Prestin
SLC26A5
707Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q496J0Q496J0_HUMAN
Prestin
SLC26A5
447Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q496J3Q496J3_HUMAN
Prestin
SLC26A5
473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD50F8WD50_HUMAN
Prestin
SLC26A5
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDL4F8WDL4_HUMAN
Prestin
SLC26A5
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010190325 – 335LLPPANPDTSL → FHTEMTRRWRP in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_010191336 – 744Missing in isoform 4. 1 PublicationAdd BLAST409
Alternative sequenceiVSP_043153438 – 469Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST32
Alternative sequenceiVSP_010192506 – 516PSYKVLGKLPE → FHTEMTRRWRP in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_010193517 – 744Missing in isoform 3. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_047640595A → ATQ in isoform 6. 1 Publication1
Alternative sequenceiVSP_010194682 – 685QVVN → FIQR in isoform 2. 1 Publication4
Alternative sequenceiVSP_010195686 – 744Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF523354 mRNA Translation: AAP31417.1
AY256823 mRNA Translation: AAP31532.1
AY256824 mRNA Translation: AAP31533.1
AY256825 mRNA Translation: AAP31534.1
AY289134 mRNA Translation: AAP43686.1
AC004668 Genomic DNA No translation available.
AC005064 Genomic DNA No translation available.
AC093701 Genomic DNA No translation available.
BC100833 mRNA Translation: AAI00834.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43629.1 [P58743-3]
CCDS43630.1 [P58743-2]
CCDS55150.1 [P58743-5]
CCDS5732.1 [P58743-4]
CCDS5733.1 [P58743-1]

NCBI Reference Sequences

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RefSeqi
NP_001161434.1, NM_001167962.1 [P58743-5]
NP_001308716.1, NM_001321787.1
NP_945350.1, NM_198999.2 [P58743-1]
NP_996766.1, NM_206883.2 [P58743-2]
NP_996767.1, NM_206884.2 [P58743-3]
NP_996768.1, NM_206885.2 [P58743-4]
XP_011514472.1, XM_011516170.2 [P58743-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.585146

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000306312; ENSP00000304783; ENSG00000170615 [P58743-1]
ENST00000339444; ENSP00000342396; ENSG00000170615 [P58743-2]
ENST00000356767; ENSP00000349210; ENSG00000170615 [P58743-4]
ENST00000393723; ENSP00000377324; ENSG00000170615 [P58743-6]
ENST00000393730; ENSP00000377331; ENSG00000170615 [P58743-5]
ENST00000393735; ENSP00000377336; ENSG00000170615 [P58743-3]
ENST00000432958; ENSP00000389733; ENSG00000170615 [P58743-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
375611

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:375611

UCSC genome browser

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UCSCi
uc003vbt.3 human [P58743-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Pump up the volume - Issue 22 of May 2002

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523354 mRNA Translation: AAP31417.1
AY256823 mRNA Translation: AAP31532.1
AY256824 mRNA Translation: AAP31533.1
AY256825 mRNA Translation: AAP31534.1
AY289134 mRNA Translation: AAP43686.1
AC004668 Genomic DNA No translation available.
AC005064 Genomic DNA No translation available.
AC093701 Genomic DNA No translation available.
BC100833 mRNA Translation: AAI00834.1
CCDSiCCDS43629.1 [P58743-3]
CCDS43630.1 [P58743-2]
CCDS55150.1 [P58743-5]
CCDS5732.1 [P58743-4]
CCDS5733.1 [P58743-1]
RefSeqiNP_001161434.1, NM_001167962.1 [P58743-5]
NP_001308716.1, NM_001321787.1
NP_945350.1, NM_198999.2 [P58743-1]
NP_996766.1, NM_206883.2 [P58743-2]
NP_996767.1, NM_206884.2 [P58743-3]
NP_996768.1, NM_206885.2 [P58743-4]
XP_011514472.1, XM_011516170.2 [P58743-1]
UniGeneiHs.585146

3D structure databases

ProteinModelPortaliP58743
SMRiP58743
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP58743, 1 interactor
STRINGi9606.ENSP00000304783

Protein family/group databases

TCDBi2.A.53.2.19 the sulfate permease (sulp) family

PTM databases

iPTMnetiP58743
PhosphoSitePlusiP58743

Polymorphism and mutation databases

BioMutaiSLC26A5
DMDMi20139418

Proteomic databases

PaxDbiP58743
PeptideAtlasiP58743
PRIDEiP58743
ProteomicsDBi57096
57097 [P58743-2]
57098 [P58743-3]
57099 [P58743-4]
57100 [P58743-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306312; ENSP00000304783; ENSG00000170615 [P58743-1]
ENST00000339444; ENSP00000342396; ENSG00000170615 [P58743-2]
ENST00000356767; ENSP00000349210; ENSG00000170615 [P58743-4]
ENST00000393723; ENSP00000377324; ENSG00000170615 [P58743-6]
ENST00000393730; ENSP00000377331; ENSG00000170615 [P58743-5]
ENST00000393735; ENSP00000377336; ENSG00000170615 [P58743-3]
ENST00000432958; ENSP00000389733; ENSG00000170615 [P58743-5]
GeneIDi375611
KEGGihsa:375611
UCSCiuc003vbt.3 human [P58743-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
375611
DisGeNETi375611
EuPathDBiHostDB:ENSG00000170615.14

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC26A5
HGNCiHGNC:9359 SLC26A5
MalaCardsiSLC26A5
MIMi604943 gene
613865 phenotype
neXtProtiNX_P58743
OpenTargetsiENSG00000170615
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA33731

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0236 Eukaryota
COG0659 LUCA
GeneTreeiENSGT00940000153858
HOGENOMiHOG000006546
HOVERGENiHBG000639
InParanoidiP58743
KOiK14703
PhylomeDBiP58743
TreeFamiTF313784

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC26A5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Prestin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
375611

Protein Ontology

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PROi
PR:P58743

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170615 Expressed in 71 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SLC26A5
ExpressionAtlasiP58743 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR030282 Prestin
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR002645 STAS_dom
IPR036513 STAS_dom_sf
PANTHERiPTHR11814 PTHR11814, 1 hit
PTHR11814:SF32 PTHR11814:SF32, 1 hit
PfamiView protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit
SUPFAMiSSF52091 SSF52091, 1 hit
TIGRFAMsiTIGR00815 sulP, 1 hit
PROSITEiView protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS26A5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58743
Secondary accession number(s): Q496J2
, Q7Z7F3, Q86UF8, Q86UF9, Q86UG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: December 5, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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