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Protein

Sulfate anion transporter 1

Gene

Slc26a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates sulfate transport with high affinity (PubMed:12217875, PubMed:27210743). Mediates oxalate transport (PubMed:12217875). Mediates bicarbonate transport (PubMed:27210743). Does not accept succinate as cosubstrate (By similarity).By similarity2 Publications

GO - Molecular functioni

  • anion:anion antiporter activity Source: UniProtKB
  • bicarbonate transmembrane transporter activity Source: GO_Central
  • chloride channel activity Source: GO_Central
  • chloride transmembrane transporter activity Source: UniProtKB
  • oxalate transmembrane transporter activity Source: UniProtKB
  • secondary active sulfate transmembrane transporter activity Source: InterPro
  • sulfate transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • bicarbonate transport Source: GO_Central
  • chloride transport Source: UniProtKB
  • oxalate transport Source: UniProtKB
  • regulation of intracellular pH Source: GO_Central
  • regulation of membrane potential Source: GO_Central
  • sulfate transport Source: UniProtKB

Keywordsi

Molecular functionIon channel
Biological processAnion exchange, Antiport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-174362 Transport and synthesis of PAPS
R-MMU-427601 Multifunctional anion exchangers

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate anion transporter 1
Short name:
SAT-1
Alternative name(s):
Solute carrier family 26 member 1
Gene namesi
Name:Slc26a1
Synonyms:Sat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2385894 Slc26a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 90HelicalSequence analysisAdd BLAST23
Transmembranei94 – 116HelicalSequence analysisAdd BLAST23
Transmembranei185 – 207HelicalSequence analysisAdd BLAST23
Transmembranei260 – 282HelicalSequence analysisAdd BLAST23
Transmembranei295 – 314HelicalSequence analysisAdd BLAST20
Transmembranei347 – 369HelicalSequence analysisAdd BLAST23
Transmembranei382 – 404HelicalSequence analysisAdd BLAST23
Transmembranei417 – 439HelicalSequence analysisAdd BLAST23
Transmembranei477 – 499HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56A → T: Decreased transporter activity. Does not affect localization to plasma membrane. 1 Publication1
Mutagenesisi190T → M: Decreased transporter activity. Loss of localization to plasma membrane. 1 Publication1
Mutagenesisi363S → L: Decreased transporter activity. Increased accumulation of protein in ER. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2176770

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801561 – 704Sulfate anion transporter 1Add BLAST704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphothreonineBy similarity1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei587PhosphoserineCombined sources1
Glycosylationi588N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei590PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP58735
PRIDEiP58735

PTM databases

iPTMnetiP58735
PhosphoSitePlusiP58735
SwissPalmiP58735

Expressioni

Gene expression databases

BgeeiENSMUSG00000046959
CleanExiMM_SAT1
ExpressionAtlasiP58735 baseline and differential
GenevisibleiP58735 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051561

Chemistry databases

BindingDBiP58735

Structurei

3D structure databases

ProteinModelPortaliP58735
SMRiP58735
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini532 – 690STASPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236 Eukaryota
COG0659 LUCA
GeneTreeiENSGT00760000119026
HOGENOMiHOG000006546
HOVERGENiHBG000639
InParanoidiP58735
KOiK14700
PhylomeDBiP58735
TreeFamiTF313784

Family and domain databases

InterProiView protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030331 SLC26A1
IPR002645 STAS_dom
IPR036513 STAS_dom_sf
PANTHERiPTHR11814 PTHR11814, 1 hit
PTHR11814:SF31 PTHR11814:SF31, 1 hit
PfamiView protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit
SUPFAMiSSF52091 SSF52091, 2 hits
TIGRFAMsiTIGR00815 sulP, 1 hit
PROSITEiView protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

Sequencei

Sequence statusi: Complete.

P58735-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDASPEPQQK GGTLVLVRRQ PPVSQGLLET LKARLKKSCT CSMPCAQALV
60 70 80 90 100
QGLFPAIHWL PQYRLKEYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY
110 120 130 140 150
SLYTSFFANL IYFLMGTSRH VNVGIFSLLC LMVGQVVDRE LQLAGFDPSQ
160 170 180 190 200
DSLGPKNNDS TLNNSATTLI IGLQDCRRDC YAIRVATALT LMAGLYQVLM
210 220 230 240 250
GILRLGFVST YLSQPLLDGF AMGASVTILT SQAKHMLGVQ IPRHQGLGMV
260 270 280 290 300
VHTWLSLLQN VGQANICDVV TSALCLGVLL AAKELSDRYR HRLKVPIPTE
310 320 330 340 350
LFVIVVATIV SHFGQLHTRF DSRVAGNIPT GFVAPQVPDP KIMWRVALDA
360 370 380 390 400
MSLALVGSAF SISLAEMFAR SHGYSVSANQ ELLAVGCCNV LPAFFHCFAT
410 420 430 440 450
SAALSKTLVK IATGCQTQLS SVVSAAVVLL VLLVLAPLFH DLQRCVLACI
460 470 480 490 500
IVVSLRGALR KVKDLPQLWR LSPADALVWV ATAATCVLVS TEAGLLAGVF
510 520 530 540 550
FSLLSLAGRT QRPRAALLAR IGDSTFYEDA AEFEGLLPPP EVRVFRFTGP
560 570 580 590 600
LYYANKDFFL RSLYRLTGLD AGHSATRKDQ GPEVGVSNRS LVDGKDLGSV
610 620 630 640 650
SSGAGLVVPL AFGFHTVVID CAPLLFLDVA GMATLKDLRR DYRALDITLL
660 670 680 690 700
LACCSPSVRD TLRKGGFLGE EQGAENELLF PSVHSAVEAA CARREELLAA

DSAL
Length:704
Mass (Da):75,788
Last modified:March 5, 2002 - v1
Checksum:iA6FA988522A6160A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032151 mRNA Translation: AAH32151.1
BC022130 mRNA Translation: AAH22130.1
BC025824 mRNA Translation: AAH25824.1
CCDSiCCDS19517.1
RefSeqiNP_001297621.1, NM_001310692.1
NP_777359.3, NM_174870.4
XP_006534974.1, XM_006534911.1
XP_011247743.1, XM_011249441.2
XP_017176343.1, XM_017320854.1
XP_017176344.1, XM_017320855.1
XP_017176345.1, XM_017320856.1
UniGeneiMm.440571

Genome annotation databases

EnsembliENSMUST00000051757; ENSMUSP00000051561; ENSMUSG00000046959
ENSMUST00000163328; ENSMUSP00000131282; ENSMUSG00000046959
GeneIDi231583
KEGGimmu:231583
UCSCiuc008yoy.3 mouse

Similar proteinsi

Entry informationi

Entry nameiS26A1_MOUSE
AccessioniPrimary (citable) accession number: P58735
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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