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UniProtKB - P58730 (MENE_LISMO)
Protein
2-succinylbenzoate--CoA ligase
Gene
menE
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Functioni
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
UniRule annotationCatalytic activityi
- EC:6.2.1.26UniRule annotation
: 1,4-dihydroxy-2-naphthoate biosynthesis Pathwayi
This protein is involved in step 5 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.
Pathwayi: menaquinone biosynthesis
This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotationView all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- o-succinylbenzoate-CoA ligase activity Source: UniProtKB-UniRule
GO - Biological processi
- menaquinone biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Ligase |
Biological process | Menaquinone biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00079 UPA01057;UER00166 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-succinylbenzoate--CoA ligaseUniRule annotation (EC:6.2.1.26UniRule annotation)Alternative name(s): o-succinylbenzoyl-CoA synthetaseUniRule annotation Short name: OSB-CoA synthetaseUniRule annotation |
Gene namesi | Name:menEUniRule annotation Ordered Locus Names:lmo1672 |
Organismi | Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) |
Taxonomic identifieri | 169963 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193164 | 1 – 467 | 2-succinylbenzoate--CoA ligaseAdd BLAST | 467 |
Proteomic databases
PaxDbi | P58730 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0318, Bacteria |
HOGENOMi | CLU_000022_59_0_9 |
PhylomeDBi | P58730 |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
HAMAPi | MF_00731, MenE, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR010192, MenE |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
TIGRFAMsi | TIGR01923, menE, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
P58730-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNWLQKRVR LSPKETALVF EGKEETFEEI SEAVERLAGK LFALGIRKDE
60 70 80 90 100
MIALLGKNDR MTFLLIHALQ QLGAVTLFLN NRLTKKEIAY QLANAEVKQV
110 120 130 140 150
IVADTFEDKV GAGISYSELA ETDYKEPELL ETWDLSRTAS IMYTSGTTGK
160 170 180 190 200
PKGVIQTYEN HWWSAVASVL NLGLTEKDSW LCAVPIFHIS GLSIMMRSVI
210 220 230 240 250
YGIPVYLEEH FDEEKITQLL ESGKVSTISV VTSMLERLLK IHGGSYHPNV
260 270 280 290 300
RTILLGGGPA SKTVLEICKQ RDIPLVQSFG MTETASQIVT LPPKDALNKI
310 320 330 340 350
GSSGKALFPA EVKIADDGEI LLKGPSITPG YLHNKKATEA SFVDGWFKTG
360 370 380 390 400
DIGYLDEEGF LFVVERRSDL IISGGENIYP TEIEHVIGEY VAVKEVAVIG
410 420 430 440 450
QPDDKWGSVP VAFIVAEETF DEDELQLICQ TNLASYKIPK QIIIVEKLPK
460
TASGKIQRNK LKERHSK
Sequence cautioni
The sequence CAC99750 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591980 Genomic DNA Translation: CAC99750.1 Different initiation. |
PIRi | AH1283 |
RefSeqi | NP_465197.1, NC_003210.1 |
Genome annotation databases
EnsemblBacteriai | CAC99750; CAC99750; CAC99750 |
GeneIDi | 985655 |
KEGGi | lmo:lmo1672 |
PATRICi | fig|169963.11.peg.1715 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591980 Genomic DNA Translation: CAC99750.1 Different initiation. |
PIRi | AH1283 |
RefSeqi | NP_465197.1, NC_003210.1 |
3D structure databases
SMRi | P58730 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 169963.lmo1672 |
Proteomic databases
PaxDbi | P58730 |
Genome annotation databases
EnsemblBacteriai | CAC99750; CAC99750; CAC99750 |
GeneIDi | 985655 |
KEGGi | lmo:lmo1672 |
PATRICi | fig|169963.11.peg.1715 |
Phylogenomic databases
eggNOGi | COG0318, Bacteria |
HOGENOMi | CLU_000022_59_0_9 |
PhylomeDBi | P58730 |
Enzyme and pathway databases
UniPathwayi | UPA00079 UPA01057;UER00166 |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
HAMAPi | MF_00731, MenE, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR010192, MenE |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
TIGRFAMsi | TIGR01923, menE, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MENE_LISMO | |
Accessioni | P58730Primary (citable) accession number: P58730 Secondary accession number(s): Q8Y6L2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 11, 2002 |
Last sequence update: | March 1, 2005 | |
Last modified: | February 23, 2022 | |
This is version 105 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families