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Protein

Toll-like receptor 7

Gene

Tlr7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • double-stranded RNA binding Source: UniProtKB
  • drug binding Source: MGI
  • signaling pattern recognition receptor activity Source: GO_Central
  • single-stranded RNA binding Source: UniProtKB
  • siRNA binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1679131 Trafficking and processing of endosomal TLR
R-MMU-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-MMU-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-MMU-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-MMU-975155 MyD88 dependent cascade initiated on endosome

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Toll-like receptor 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tlr7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2176882 Tlr7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 837ExtracellularSequence analysisAdd BLAST811
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei838 – 858HelicalSequence analysisAdd BLAST21
Topological domaini859 – 1050CytoplasmicSequence analysisAdd BLAST192

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6085

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1757

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003473427 – 1050Toll-like receptor 7Add BLAST1024

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi524N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi535N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi591N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi680N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi721N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi800N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P58681

PeptideAtlas

More...
PeptideAtlasi
P58681

PRoteomics IDEntifications database

More...
PRIDEi
P58681

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P58681

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P58681

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000044583 Expressed in 97 organ(s), highest expression level in bone marrow macrophage

CleanEx database of gene expression profiles

More...
CleanExi
MM_TLR7

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P58681 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P58681 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with UNC93B1. Interacts with SMPDL3B (PubMed:26095358).By similarity2 Publications

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P58681, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000061853

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P58681

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P58681

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P58681

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati42 – 64LRR 1Add BLAST23
Repeati65 – 87LRR 2Add BLAST23
Repeati89 – 111LRR 3Add BLAST23
Repeati126 – 149LRR 4Add BLAST24
Repeati151 – 170LRR 5Add BLAST20
Repeati171 – 195LRR 6Add BLAST25
Repeati203 – 226LRR 7Add BLAST24
Repeati228 – 247LRR 8Add BLAST20
Repeati248 – 273LRR 9Add BLAST26
Repeati275 – 289LRR 10Add BLAST15
Repeati290 – 312LRR 11Add BLAST23
Repeati314 – 337LRR 12Add BLAST24
Repeati339 – 364LRR 13Add BLAST26
Repeati369 – 392LRR 14Add BLAST24
Repeati396 – 419LRR 15Add BLAST24
Repeati421 – 443LRR 16Add BLAST23
Repeati493 – 516LRR 17Add BLAST24
Repeati517 – 542LRR 18Add BLAST26
Repeati543 – 565LRR 19Add BLAST23
Repeati567 – 589LRR 20Add BLAST23
Repeati596 – 619LRR 21Add BLAST24
Repeati620 – 645LRR 22Add BLAST26
Repeati650 – 673LRR 23Add BLAST24
Repeati675 – 698LRR 24Add BLAST24
Repeati699 – 722LRR 25Add BLAST24
Repeati724 – 746LRR 26Add BLAST23
Repeati747 – 770LRR 27Add BLAST24
Repeati773 – 796LRR 28Add BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini890 – 1037TIRPROSITE-ProRule annotationAdd BLAST148

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4641 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159771

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230468

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018601

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P58681

KEGG Orthology (KO)

More...
KOi
K05404

Identification of Orthologs from Complete Genome Data

More...
OMAi
MLNFTKN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G023M

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P58681

TreeFam database of animal gene trees

More...
TreeFami
TF325595

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10140, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR026880 TLR7
IPR035897 Toll_tir_struct_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR44312:SF1 PTHR44312:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 4 hits
PF01582 TIR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 12 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 19 hits
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P58681-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFSMWTRKR QILIFLNMLL VSRVFGFRWF PKTLPCEVKV NIPEAHVIVD
60 70 80 90 100
CTDKHLTEIP EGIPTNTTNL TLTINHIPSI SPDSFRRLNH LEEIDLRCNC
110 120 130 140 150
VPVLLGSKAN VCTKRLQIRP GSFSGLSDLK ALYLDGNQLL EIPQDLPSSL
160 170 180 190 200
HLLSLEANNI FSITKENLTE LVNIETLYLG QNCYYRNPCN VSYSIEKDAF
210 220 230 240 250
LVMRNLKVLS LKDNNVTAVP TTLPPNLLEL YLYNNIIKKI QENDFNNLNE
260 270 280 290 300
LQVLDLSGNC PRCYNVPYPC TPCENNSPLQ IHDNAFNSLT ELKVLRLHSN
310 320 330 340 350
SLQHVPPTWF KNMRNLQELD LSQNYLAREI EEAKFLHFLP NLVELDFSFN
360 370 380 390 400
YELQVYHASI TLPHSLSSLE NLKILRVKGY VFKELKNSSL SVLHKLPRLE
410 420 430 440 450
VLDLGTNFIK IADLNIFKHF ENLKLIDLSV NKISPSEESR EVGFCPNAQT
460 470 480 490 500
SVDRHGPQVL EALHYFRYDE YARSCRFKNK EPPSFLPLNA DCHIYGQTLD
510 520 530 540 550
LSRNNIFFIK PSDFQHLSFL KCLNLSGNTI GQTLNGSELW PLRELRYLDF
560 570 580 590 600
SNNRLDLLYS TAFEELQSLE VLDLSSNSHY FQAEGITHML NFTKKLRLLD
610 620 630 640 650
KLMMNDNDIS TSASRTMESD SLRILEFRGN HLDVLWRAGD NRYLDFFKNL
660 670 680 690 700
FNLEVLDISR NSLNSLPPEV FEGMPPNLKN LSLAKNGLKS FFWDRLQLLK
710 720 730 740 750
HLEILDLSHN QLTKVPERLA NCSKSLTTLI LKHNQIRQLT KYFLEDALQL
760 770 780 790 800
RYLDISSNKI QVIQKTSFPE NVLNNLEMLV LHHNRFLCNC DAVWFVWWVN
810 820 830 840 850
HTDVTIPYLA TDVTCVGPGA HKGQSVISLD LYTCELDLTN LILFSVSISS
860 870 880 890 900
VLFLMVVMTT SHLFFWDMWY IYYFWKAKIK GYQHLQSMES CYDAFIVYDT
910 920 930 940 950
KNSAVTEWVL QELVAKLEDP REKHFNLCLE ERDWLPGQPV LENLSQSIQL
960 970 980 990 1000
SKKTVFVMTQ KYAKTESFKM AFYLSHQRLL DEKVDVIILI FLEKPLQKSK
1010 1020 1030 1040 1050
FLQLRKRLCR SSVLEWPANP QAHPYFWQCL KNALTTDNHV AYSQMFKETV
Length:1,050
Mass (Da):121,837
Last modified:January 31, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i495B75DEE849D8EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AHJ1A2AHJ1_MOUSE
Toll-like receptor 7
Tlr7
49Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AHJ2A2AHJ2_MOUSE
Toll-like receptor 7
Tlr7
47Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY035889 mRNA Translation: AAK62676.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30531.1
CCDS72469.1

NCBI Reference Sequences

More...
RefSeqi
NP_001277684.1, NM_001290755.1
NP_001277685.1, NM_001290756.1
NP_001277686.1, NM_001290757.1
NP_573474.1, NM_133211.4
XP_011246087.1, XM_011247785.1
XP_011246088.1, XM_011247786.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.23979
Mm.489377

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000060719; ENSMUSP00000061853; ENSMUSG00000044583
ENSMUST00000112161; ENSMUSP00000107787; ENSMUSG00000044583
ENSMUST00000112164; ENSMUSP00000107789; ENSMUSG00000044583

Database of genes from NCBI RefSeq genomes

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GeneIDi
170743

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:170743

UCSC genome browser

More...
UCSCi
uc009uwz.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035889 mRNA Translation: AAK62676.1
CCDSiCCDS30531.1
CCDS72469.1
RefSeqiNP_001277684.1, NM_001290755.1
NP_001277685.1, NM_001290756.1
NP_001277686.1, NM_001290757.1
NP_573474.1, NM_133211.4
XP_011246087.1, XM_011247785.1
XP_011246088.1, XM_011247786.1
UniGeneiMm.23979
Mm.489377

3D structure databases

ProteinModelPortaliP58681
SMRiP58681
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP58681, 2 interactors
STRINGi10090.ENSMUSP00000061853

Chemistry databases

BindingDBiP58681
ChEMBLiCHEMBL6085
GuidetoPHARMACOLOGYi1757

PTM databases

iPTMnetiP58681
PhosphoSitePlusiP58681

Proteomic databases

PaxDbiP58681
PeptideAtlasiP58681
PRIDEiP58681

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060719; ENSMUSP00000061853; ENSMUSG00000044583
ENSMUST00000112161; ENSMUSP00000107787; ENSMUSG00000044583
ENSMUST00000112164; ENSMUSP00000107789; ENSMUSG00000044583
GeneIDi170743
KEGGimmu:170743
UCSCiuc009uwz.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51284
MGIiMGI:2176882 Tlr7

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000159771
HOGENOMiHOG000230468
HOVERGENiHBG018601
InParanoidiP58681
KOiK05404
OMAiMLNFTKN
OrthoDBiEOG091G023M
PhylomeDBiP58681
TreeFamiTF325595

Enzyme and pathway databases

ReactomeiR-MMU-1679131 Trafficking and processing of endosomal TLR
R-MMU-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-MMU-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-MMU-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-MMU-975155 MyD88 dependent cascade initiated on endosome

Miscellaneous databases

Protein Ontology

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PROi
PR:P58681

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000044583 Expressed in 97 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_TLR7
ExpressionAtlasiP58681 baseline and differential
GenevisibleiP58681 MM

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR026880 TLR7
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR44312:SF1 PTHR44312:SF1, 1 hit
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 4 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 12 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 19 hits
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLR7_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58681
Secondary accession number(s): Q923I1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: December 5, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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