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Protein

Protein eva-1 homolog C

Gene

Eva1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds heparin.By similarity

GO - Molecular functioni

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein eva-1 homolog C
Alternative name(s):
Protein FAM176C
Gene namesi
Name:Eva1c
Synonyms:Fam176c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1918217 Eva1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini49 – 321ExtracellularSequence analysisAdd BLAST273
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 440CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 48Sequence analysisAdd BLAST48
ChainiPRO_000001767249 – 440Protein eva-1 homolog CAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP58659
PaxDbiP58659
PRIDEiP58659

PTM databases

iPTMnetiP58659
PhosphoSitePlusiP58659

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000039903 Expressed in 122 organ(s), highest expression level in decidua
CleanExiMM_4931408A02RIK
ExpressionAtlasiP58659 baseline and differential
GenevisibleiP58659 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036695

Structurei

3D structure databases

ProteinModelPortaliP58659
SMRiP58659
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 159SUEL-type lectin 1PROSITE-ProRule annotationAdd BLAST93
Domaini168 – 260SUEL-type lectin 2PROSITE-ProRule annotationAdd BLAST93

Sequence similaritiesi

Belongs to the EVA1 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4729 Eukaryota
ENOG4111BWI LUCA
GeneTreeiENSGT00900000140931
HOGENOMiHOG000293165
HOVERGENiHBG051238
InParanoidiP58659
OMAiCKPTEHK
OrthoDBiEOG091G0BAI
PhylomeDBiP58659
TreeFamiTF328177

Family and domain databases

InterProiView protein in InterPro
IPR039500 EVA1_dom
IPR000922 Lectin_gal-bd_dom
PfamiView protein in Pfam
PF14851 FAM176, 1 hit
PF02140 Gal_Lectin, 2 hits
PROSITEiView protein in PROSITE
PS50228 SUEL_LECTIN, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P58659-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLPGHPRPP PAPQSAQNQG LRRQVEPPGQ LLRLFYCTVL VCSKETSALT
60 70 80 90 100
DFSGYLTKLL QNHTAYACDG DYLNLQCPRH STISVQSAFY GQDYQMCSSQ
110 120 130 140 150
EPISQREDNL TCVASTTLQK VLDECQNQRA CHLLVNSRVF GPDLCPGSSK
160 170 180 190 200
YLLVSFKCQP NELKNKTVCE NQELKLHCHE SKFLNIYSAA YGRRTQQRDI
210 220 230 240 250
CSSGAELLPP FDCLSYTALQ VLSRRCYGKQ RCKVLVDNYH FGSPCLPGVK
260 270 280 290 300
KYLTVAYACV PKNILTAVDP AVANLNPSLK KDDEHGITFN PSGSRVVRKD
310 320 330 340 350
GVIVSNSLAA FAYIRAHPER AALLFMSSVC IGLLLTLCAL VIRVSCTKDF
360 370 380 390 400
RELRQGREHL VLGSDKAEED SEEDLEEEDS SDSQFPEELS RFCRTSYPAY
410 420 430 440
SSIEAAELAE RIERREQVIQ EIWMNSGLDS SLPRNVGHFY
Length:440
Mass (Da):49,287
Last modified:July 10, 2007 - v2
Checksum:iAD4782A666D90EF0
GO
Isoform 2 (identifier: P58659-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-259: Missing.

Show »
Length:392
Mass (Da):43,873
Checksum:iC876955D920EB2AB
GO
Isoform 3 (identifier: P58659-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:345
Mass (Da):38,692
Checksum:i299DA8767414ACF5
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z1H0D3Z1H0_MOUSE
Protein eva-1 homolog C
Eva1c 4931408A02Rik
145Annotation score:
A0A338P750A0A338P750_MOUSE
Protein eva-1 homolog C
Eva1c
333Annotation score:
D6RCJ7D6RCJ7_MOUSE
Protein eva-1 homolog C
Eva1c 4931408A02Rik
70Annotation score:
A0A384DV69A0A384DV69_MOUSE
Protein eva-1 homolog C
Eva1c
446Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti347T → R in AAI32306 (PubMed:15489334).Curated1
Sequence conflicti367A → S in AAL40410 (PubMed:11707072).Curated1
Sequence conflicti384Q → E in AAI32306 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0266001 – 95Missing in isoform 3. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_026601212 – 259Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358257 mRNA Translation: AAL40410.1
AK016443 mRNA Translation: BAB30238.1
BC100350 mRNA Translation: AAI00351.1
BC132305 mRNA Translation: AAI32306.1
CCDSiCCDS28319.1 [P58659-2]
CCDS57038.1 [P58659-1]
CCDS84261.1 [P58659-3]
RefSeqiNP_001186139.1, NM_001199210.2 [P58659-1]
NP_001303689.1, NM_001316760.1 [P58659-3]
NP_001303690.1, NM_001316761.1
NP_081903.1, NM_027627.3 [P58659-2]
XP_017172620.1, XM_017317131.1 [P58659-3]
XP_017172621.1, XM_017317132.1 [P58659-3]
UniGeneiMm.253077
Mm.487127

Genome annotation databases

EnsembliENSMUST00000037539; ENSMUSP00000036695; ENSMUSG00000039903 [P58659-1]
ENSMUST00000099543; ENSMUSP00000097141; ENSMUSG00000039903 [P58659-2]
ENSMUST00000231964; ENSMUSP00000155994; ENSMUSG00000039903 [P58659-3]
GeneIDi70967
KEGGimmu:70967
UCSCiuc007zwp.2 mouse [P58659-1]
uc007zwq.2 mouse [P58659-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358257 mRNA Translation: AAL40410.1
AK016443 mRNA Translation: BAB30238.1
BC100350 mRNA Translation: AAI00351.1
BC132305 mRNA Translation: AAI32306.1
CCDSiCCDS28319.1 [P58659-2]
CCDS57038.1 [P58659-1]
CCDS84261.1 [P58659-3]
RefSeqiNP_001186139.1, NM_001199210.2 [P58659-1]
NP_001303689.1, NM_001316760.1 [P58659-3]
NP_001303690.1, NM_001316761.1
NP_081903.1, NM_027627.3 [P58659-2]
XP_017172620.1, XM_017317131.1 [P58659-3]
XP_017172621.1, XM_017317132.1 [P58659-3]
UniGeneiMm.253077
Mm.487127

3D structure databases

ProteinModelPortaliP58659
SMRiP58659
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036695

PTM databases

iPTMnetiP58659
PhosphoSitePlusiP58659

Proteomic databases

MaxQBiP58659
PaxDbiP58659
PRIDEiP58659

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037539; ENSMUSP00000036695; ENSMUSG00000039903 [P58659-1]
ENSMUST00000099543; ENSMUSP00000097141; ENSMUSG00000039903 [P58659-2]
ENSMUST00000231964; ENSMUSP00000155994; ENSMUSG00000039903 [P58659-3]
GeneIDi70967
KEGGimmu:70967
UCSCiuc007zwp.2 mouse [P58659-1]
uc007zwq.2 mouse [P58659-2]

Organism-specific databases

CTDi59271
MGIiMGI:1918217 Eva1c

Phylogenomic databases

eggNOGiKOG4729 Eukaryota
ENOG4111BWI LUCA
GeneTreeiENSGT00900000140931
HOGENOMiHOG000293165
HOVERGENiHBG051238
InParanoidiP58659
OMAiCKPTEHK
OrthoDBiEOG091G0BAI
PhylomeDBiP58659
TreeFamiTF328177

Miscellaneous databases

PROiPR:P58659
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039903 Expressed in 122 organ(s), highest expression level in decidua
CleanExiMM_4931408A02RIK
ExpressionAtlasiP58659 baseline and differential
GenevisibleiP58659 MM

Family and domain databases

InterProiView protein in InterPro
IPR039500 EVA1_dom
IPR000922 Lectin_gal-bd_dom
PfamiView protein in Pfam
PF14851 FAM176, 1 hit
PF02140 Gal_Lectin, 2 hits
PROSITEiView protein in PROSITE
PS50228 SUEL_LECTIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEVA1C_MOUSE
AccessioniPrimary (citable) accession number: P58659
Secondary accession number(s): A2RSZ2, Q497W3, Q9D4L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 10, 2007
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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