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Protein

Protein eva-1 homolog C

Gene

EVA1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds heparin.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • heparin binding Source: UniProtKB

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein eva-1 homolog C
Alternative name(s):
Protein FAM176C
SUE21
Gene namesi
Name:EVA1C
Synonyms:C21orf63, C21orf64, FAM176C
ORF Names:PRED34, UNQ2504/PRO5993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000166979.12
HGNCiHGNC:13239 EVA1C
neXtProtiNX_P58658

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini49 – 322ExtracellularSequence analysisAdd BLAST274
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 441CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi59271
OpenTargetsiENSG00000166979
PharmGKBiPA25858

Polymorphism and mutation databases

BioMutaiEVA1C

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 48Sequence analysisAdd BLAST48
ChainiPRO_000001767149 – 441Protein eva-1 homolog CAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP58658
PaxDbiP58658
PeptideAtlasiP58658
PRIDEiP58658
ProteomicsDBi57094
57095 [P58658-2]

PTM databases

iPTMnetiP58658
PhosphoSitePlusiP58658

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000166979 Expressed in 185 organ(s), highest expression level in lower esophagus muscularis layer
CleanExiHS_C21orf63
ExpressionAtlasiP58658 baseline and differential
GenevisibleiP58658 HS

Organism-specific databases

HPAiCAB034174
HPA015720
HPA029944

Interactioni

Protein-protein interaction databases

BioGridi121863, 39 interactors
IntActiP58658, 1 interactor
STRINGi9606.ENSP00000300255

Structurei

3D structure databases

ProteinModelPortaliP58658
SMRiP58658
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 159SUEL-type lectin 1PROSITE-ProRule annotationAdd BLAST93
Domaini168 – 260SUEL-type lectin 2PROSITE-ProRule annotationAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi373 – 379Poly-Glu7

Sequence similaritiesi

Belongs to the EVA1 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4729 Eukaryota
ENOG4111BWI LUCA
GeneTreeiENSGT00900000140931
HOGENOMiHOG000293165
HOVERGENiHBG051238
InParanoidiP58658
OMAiCKPTEHK
OrthoDBiEOG091G0BAI
PhylomeDBiP58658
TreeFamiTF328177

Family and domain databases

InterProiView protein in InterPro
IPR039500 EVA1_dom
IPR000922 Lectin_gal-bd_dom
PfamiView protein in Pfam
PF14851 FAM176, 1 hit
PF02140 Gal_Lectin, 2 hits
PROSITEiView protein in PROSITE
PS50228 SUEL_LECTIN, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P58658-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLPGRARQP PTPQPVQHPG LRRQVEPPGQ LLRLFYCTVL VCSKEISALT
60 70 80 90 100
DFSGYLTKLL QNHTTYACDG DYLNLQCPRH STISVQSAFY GQDYQMCSSQ
110 120 130 140 150
KPASQREDSL TCVAATTFQK VLDECQNQRA CHLLVNSRVF GPDLCPGSSK
160 170 180 190 200
YLLVSFKCQP NELKNKTVCE DQELKLHCHE SKFLNIYSAT YGRRTQERDI
210 220 230 240 250
CSSKAERLPP FDCLSYSALQ VLSRRCYGKQ RCKIIVNNHH FGSPCLPGVK
260 270 280 290 300
KYLTVTYACV PKNILTAIDP AIANLKPSLK QKDGEYGINF DPSGSKVLRK
310 320 330 340 350
DGILVSNSLA AFAYIRAHPE RAALLFVSSV CIGLALTLCA LVIRESCAKD
360 370 380 390 400
FRDLQLGREQ LVPGSDKVEE DSEDEEEEED PSESDFPGEL SGFCRTSYPI
410 420 430 440
YSSIEAAELA ERIERREQII QEIWMNSGLD TSLPRNMGQF Y
Length:441
Mass (Da):49,483
Last modified:January 23, 2002 - v1
Checksum:i31B2C9C12915ACD4
GO
Isoform 2 (identifier: P58658-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-69: GYLTKLLQNHTTYACD → EGAGRMPEPAGLPPPG
     70-441: Missing.

Show »
Length:69
Mass (Da):7,458
Checksum:iE02ED7CE215B1730
GO
Isoform 3 (identifier: P58658-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     285-287: Missing.

Note: No experimental confirmation available.
Show »
Length:438
Mass (Da):49,134
Checksum:i56E2699893F27979
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MC74B5MC74_HUMAN
Protein eva-1 homolog C
EVA1C
393Annotation score:
F8WEK6F8WEK6_HUMAN
Protein eva-1 homolog C
EVA1C
192Annotation score:
C9JS02C9JS02_HUMAN
Protein eva-1 homolog C
EVA1C
153Annotation score:
A0A0C4DG64A0A0C4DG64_HUMAN
Protein eva-1 homolog C
EVA1C
70Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19P → H in AAH38710 (PubMed:15489334).Curated1
Sequence conflicti284 – 286Missing in AAH38710 (PubMed:15489334).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00310354 – 69GYLTK…TYACD → EGAGRMPEPAGLPPPG in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_00310470 – 441Missing in isoform 2. 1 PublicationAdd BLAST372
Alternative sequenceiVSP_055198285 – 287Missing in isoform 3. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358258 mRNA Translation: AAL40411.1
AY040087 mRNA Translation: AAK74135.1
AY358787 mRNA Translation: AAQ89147.1
AP000269 Genomic DNA No translation available.
AP000270 Genomic DNA No translation available.
AP000271 Genomic DNA No translation available.
AP000272 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09872.1
BC038710 mRNA Translation: AAH38710.1
CCDSiCCDS13614.1 [P58658-1]
CCDS68186.1 [P58658-3]
RefSeqiNP_001273485.1, NM_001286556.1 [P58658-3]
NP_478067.2, NM_058187.4 [P58658-1]
UniGeneiHs.208358

Genome annotation databases

EnsembliENST00000300255; ENSP00000300255; ENSG00000166979 [P58658-1]
ENST00000382699; ENSP00000372146; ENSG00000166979 [P58658-3]
GeneIDi59271
KEGGihsa:59271
UCSCiuc002ypr.3 human [P58658-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358258 mRNA Translation: AAL40411.1
AY040087 mRNA Translation: AAK74135.1
AY358787 mRNA Translation: AAQ89147.1
AP000269 Genomic DNA No translation available.
AP000270 Genomic DNA No translation available.
AP000271 Genomic DNA No translation available.
AP000272 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09872.1
BC038710 mRNA Translation: AAH38710.1
CCDSiCCDS13614.1 [P58658-1]
CCDS68186.1 [P58658-3]
RefSeqiNP_001273485.1, NM_001286556.1 [P58658-3]
NP_478067.2, NM_058187.4 [P58658-1]
UniGeneiHs.208358

3D structure databases

ProteinModelPortaliP58658
SMRiP58658
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121863, 39 interactors
IntActiP58658, 1 interactor
STRINGi9606.ENSP00000300255

PTM databases

iPTMnetiP58658
PhosphoSitePlusiP58658

Polymorphism and mutation databases

BioMutaiEVA1C

Proteomic databases

EPDiP58658
PaxDbiP58658
PeptideAtlasiP58658
PRIDEiP58658
ProteomicsDBi57094
57095 [P58658-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300255; ENSP00000300255; ENSG00000166979 [P58658-1]
ENST00000382699; ENSP00000372146; ENSG00000166979 [P58658-3]
GeneIDi59271
KEGGihsa:59271
UCSCiuc002ypr.3 human [P58658-1]

Organism-specific databases

CTDi59271
DisGeNETi59271
EuPathDBiHostDB:ENSG00000166979.12
GeneCardsiEVA1C
H-InvDBiHIX0027783
HGNCiHGNC:13239 EVA1C
HPAiCAB034174
HPA015720
HPA029944
neXtProtiNX_P58658
OpenTargetsiENSG00000166979
PharmGKBiPA25858
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4729 Eukaryota
ENOG4111BWI LUCA
GeneTreeiENSGT00900000140931
HOGENOMiHOG000293165
HOVERGENiHBG051238
InParanoidiP58658
OMAiCKPTEHK
OrthoDBiEOG091G0BAI
PhylomeDBiP58658
TreeFamiTF328177

Miscellaneous databases

ChiTaRSiEVA1C human
GenomeRNAii59271
PROiPR:P58658

Gene expression databases

BgeeiENSG00000166979 Expressed in 185 organ(s), highest expression level in lower esophagus muscularis layer
CleanExiHS_C21orf63
ExpressionAtlasiP58658 baseline and differential
GenevisibleiP58658 HS

Family and domain databases

InterProiView protein in InterPro
IPR039500 EVA1_dom
IPR000922 Lectin_gal-bd_dom
PfamiView protein in Pfam
PF14851 FAM176, 1 hit
PF02140 Gal_Lectin, 2 hits
PROSITEiView protein in PROSITE
PS50228 SUEL_LECTIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEVA1C_HUMAN
AccessioniPrimary (citable) accession number: P58658
Secondary accession number(s): A6ND58, Q8IXZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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