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Protein

Toxin Ado1

Gene
N/A
Organism
Agriosphodrus dohrni (Japanese assassin-bug)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin Ado1
OrganismiAgriosphodrus dohrni (Japanese assassin-bug)
Taxonomic identifieri184613 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraHeteropteraPanheteropteraCimicomorphaReduviidaeHarpactorinaeHarpactoriniAgriosphodrus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000448891 – 35Toxin Ado1Add BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 20
Disulfide bondi12 ↔ 25
Disulfide bondi19 ↔ 32

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 26Combined sources4
Turni27 – 30Combined sources4
Beta strandi31 – 34Combined sources4

3D structure databases

ProteinModelPortaliP58608
SMRiP58608
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58608

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Belongs to the assassin bug toxin family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR012325 Assassin_bug_toxin
PfamiView protein in Pfam
PF08117 Toxin_30, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD591704 Assassin_bug_toxin, 1 hit
PROSITEiView protein in PROSITE
PS60010 ASSASSIN_BUG_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P58608-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
ADDDCLPRGS KCLGENKQCC KGTTCMFYAN RCVGV
Length:35
Mass (Da):3,787
Last modified:January 23, 2002 - v1
Checksum:i3E83D94C6D614E88
GO

Mass spectrometryi

Molecular mass is 3781.3 Da from positions 1 - 35. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiADO1_AGRDO
AccessioniPrimary (citable) accession number: P58608
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: November 22, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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