UniProtKB - P58546 (MTPN_HUMAN)
Protein
Myotrophin
Gene
MTPN
Organism
Homo sapiens (Human)
Status
Functioni
Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.By similarity3 Publications
Miscellaneous
This protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN.
GO - Molecular functioni
- sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- catecholamine metabolic process Source: Ensembl
- cellular response to mechanical stimulus Source: Ensembl
- cerebellar granule cell differentiation Source: Ensembl
- neuron differentiation Source: UniProtKB
- positive regulation of cardiac muscle hypertrophy Source: UniProtKB
- positive regulation of cell growth Source: UniProtKB
- positive regulation of macromolecule biosynthetic process Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of protein metabolic process Source: UniProtKB
- regulation of barbed-end actin filament capping Source: UniProtKB
- regulation of cell size Source: UniProtKB
- regulation of striated muscle tissue development Source: UniProtKB
- regulation of translation Source: UniProtKB
- skeletal muscle tissue regeneration Source: Ensembl
- striated muscle cell differentiation Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | P58546 |
Names & Taxonomyi
Protein namesi | Recommended name: MyotrophinAlternative name(s): Protein V-1 |
Gene namesi | Name:MTPN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15667, MTPN |
MIMi | 606484, gene |
neXtProti | NX_P58546 |
VEuPathDBi | HostDB:ENSG00000105887.10 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm Curated
- perinuclear region By similarity
Cytoskeleton
- F-actin capping protein complex Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- axon Source: Ensembl
- cytoplasm Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 136319 |
OpenTargetsi | ENSG00000105887 |
PharmGKBi | PA31271 |
Miscellaneous databases
Pharosi | P58546, Tbio |
Genetic variation databases
BioMutai | MTPN |
DMDMi | 20138912 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000067031 | 2 – 118 | MyotrophinAdd BLAST | 117 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylcysteineBy similarity | 1 | |
Modified residuei | 4 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 11 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 24 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 31 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P58546 |
jPOSTi | P58546 |
MassIVEi | P58546 |
PaxDbi | P58546 |
PeptideAtlasi | P58546 |
PRIDEi | P58546 |
ProteomicsDBi | 57087 |
TopDownProteomicsi | P58546 |
2D gel databases
OGPi | P58546 |
PTM databases
iPTMneti | P58546 |
PhosphoSitePlusi | P58546 |
SwissPalmi | P58546 |
Expressioni
Tissue specificityi
Ubiquitous.1 Publication
Inductioni
Up-regulated in heart left ventricle of patients with severe coronary artery disease and history of myocardial ischemia. Up-regulated in heart left ventricle of patients with dilated cardiomyopathy.1 Publication
Gene expression databases
Bgeei | ENSG00000105887, Expressed in caudate nucleus and 128 other tissues |
ExpressionAtlasi | P58546, baseline and differential |
Genevisiblei | P58546, HS |
Organism-specific databases
HPAi | ENSG00000105887, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RELA (By similarity).
Interacts with the heterodimer formed by CAPZA1 and CAPZB.
By similarity2 PublicationsProtein-protein interaction databases
BioGRIDi | 126455, 70 interactors |
DIPi | DIP-50234N |
IntActi | P58546, 25 interactors |
STRINGi | 9606.ENSP00000376800 |
Miscellaneous databases
RNActi | P58546, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P58546 |
SMRi | P58546 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P58546 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 2 – 30 | ANK 1Add BLAST | 29 | |
Repeati | 34 – 66 | ANK 2Add BLAST | 33 | |
Repeati | 67 – 99 | ANK 3Add BLAST | 33 |
Sequence similaritiesi
Belongs to the myotrophin family.Curated
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG4214, Eukaryota |
GeneTreei | ENSGT00430000031071 |
HOGENOMi | CLU_000134_45_7_1 |
InParanoidi | P58546 |
OMAi | TALIDCT |
OrthoDBi | 1435166at2759 |
PhylomeDBi | P58546 |
TreeFami | TF327387 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P58546-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTAFEATDN QAIKALLQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JL85 | C9JL85_HUMAN | Myotrophin | MTPN | 52 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC015987 Genomic DNA No translation available. BC028093 mRNA Translation: AAH28093.1 |
CCDSi | CCDS5842.1 |
RefSeqi | NP_665807.1, NM_145808.3 |
Genome annotation databases
Ensembli | ENST00000393085; ENSP00000376800; ENSG00000105887 |
GeneIDi | 136319 |
KEGGi | hsa:136319 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC015987 Genomic DNA No translation available. BC028093 mRNA Translation: AAH28093.1 |
CCDSi | CCDS5842.1 |
RefSeqi | NP_665807.1, NM_145808.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3AAA | X-ray | 2.20 | C | 1-118 | [»] | |
BMRBi | P58546 | |||||
SMRi | P58546 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 126455, 70 interactors |
DIPi | DIP-50234N |
IntActi | P58546, 25 interactors |
STRINGi | 9606.ENSP00000376800 |
PTM databases
iPTMneti | P58546 |
PhosphoSitePlusi | P58546 |
SwissPalmi | P58546 |
Genetic variation databases
BioMutai | MTPN |
DMDMi | 20138912 |
2D gel databases
OGPi | P58546 |
Proteomic databases
EPDi | P58546 |
jPOSTi | P58546 |
MassIVEi | P58546 |
PaxDbi | P58546 |
PeptideAtlasi | P58546 |
PRIDEi | P58546 |
ProteomicsDBi | 57087 |
TopDownProteomicsi | P58546 |
Protocols and materials databases
Antibodypediai | 18167, 90 antibodies |
DNASUi | 136319 |
Genome annotation databases
Ensembli | ENST00000393085; ENSP00000376800; ENSG00000105887 |
GeneIDi | 136319 |
KEGGi | hsa:136319 |
Organism-specific databases
CTDi | 136319 |
DisGeNETi | 136319 |
GeneCardsi | MTPN |
HGNCi | HGNC:15667, MTPN |
HPAi | ENSG00000105887, Low tissue specificity |
MIMi | 606484, gene |
neXtProti | NX_P58546 |
OpenTargetsi | ENSG00000105887 |
PharmGKBi | PA31271 |
VEuPathDBi | HostDB:ENSG00000105887.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4214, Eukaryota |
GeneTreei | ENSGT00430000031071 |
HOGENOMi | CLU_000134_45_7_1 |
InParanoidi | P58546 |
OMAi | TALIDCT |
OrthoDBi | 1435166at2759 |
PhylomeDBi | P58546 |
TreeFami | TF327387 |
Enzyme and pathway databases
PathwayCommonsi | P58546 |
Miscellaneous databases
BioGRID-ORCSi | 136319, 10 hits in 880 CRISPR screens |
ChiTaRSi | MTPN, human |
EvolutionaryTracei | P58546 |
GeneWikii | MTPN |
GenomeRNAii | 136319 |
Pharosi | P58546, Tbio |
PROi | PR:P58546 |
RNActi | P58546, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105887, Expressed in caudate nucleus and 128 other tissues |
ExpressionAtlasi | P58546, baseline and differential |
Genevisiblei | P58546, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTPN_HUMAN | |
Accessioni | P58546Primary (citable) accession number: P58546 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families