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Protein

Myotrophin

Gene

MTPN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.By similarity3 Publications

Miscellaneous

This protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Myotrophin
Alternative name(s):
Protein V-1
Gene namesi
Name:MTPN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105887.10
HGNCiHGNC:15667 MTPN
MIMi606484 gene
neXtProtiNX_P58546

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi136319
OpenTargetsiENSG00000105887
PharmGKBiPA31271

Polymorphism and mutation databases

BioMutaiMTPN
DMDMi20138912

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000670312 – 118MyotrophinAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineBy similarity1
Modified residuei4N6-acetyllysineCombined sources1
Modified residuei11N6-acetyllysineCombined sources1
Modified residuei24N6-acetyllysineCombined sources1
Modified residuei31PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP58546
PaxDbiP58546
PeptideAtlasiP58546
PRIDEiP58546
ProteomicsDBi57087
TopDownProteomicsiP58546

2D gel databases

OGPiP58546

PTM databases

iPTMnetiP58546
PhosphoSitePlusiP58546

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Inductioni

Up-regulated in heart left ventricle of patients with severe coronary artery disease and history of myocardial ischemia. Up-regulated in heart left ventricle of patients with dilated cardiomyopathy.1 Publication

Gene expression databases

BgeeiENSG00000105887 Expressed in 101 organ(s), highest expression level in caudate nucleus
CleanExiHS_MTPN
ExpressionAtlasiP58546 baseline and differential
GenevisibleiP58546 HS

Organism-specific databases

HPAiHPA019735

Interactioni

Subunit structurei

Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB.By similarity2 Publications

Protein-protein interaction databases

BioGridi126455, 35 interactors
DIPiDIP-50234N
IntActiP58546, 19 interactors
STRINGi9606.ENSP00000376800

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP58546
SMRiP58546
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58546

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 30ANK 1Add BLAST29
Repeati34 – 66ANK 2Add BLAST33
Repeati67 – 99ANK 3Add BLAST33

Sequence similaritiesi

Belongs to the myotrophin family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4214 Eukaryota
ENOG4111U90 LUCA
GeneTreeiENSGT00430000031071
HOGENOMiHOG000276399
HOVERGENiHBG019067
InParanoidiP58546
OMAiTALIDCT
OrthoDBiEOG091G0Y4J
PhylomeDBiP58546
TreeFamiTF327387

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P58546-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTAFEATDN QAIKALLQ
Length:118
Mass (Da):12,895
Last modified:January 23, 2007 - v2
Checksum:i9097FFDF61D329A2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JL85C9JL85_HUMAN
Myotrophin
MTPN
52Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015987 Genomic DNA No translation available.
BC028093 mRNA Translation: AAH28093.1
CCDSiCCDS5842.1
RefSeqiNP_665807.1, NM_145808.3
UniGeneiHs.602015

Genome annotation databases

EnsembliENST00000393085; ENSP00000376800; ENSG00000105887
GeneIDi136319
KEGGihsa:136319

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015987 Genomic DNA No translation available.
BC028093 mRNA Translation: AAH28093.1
CCDSiCCDS5842.1
RefSeqiNP_665807.1, NM_145808.3
UniGeneiHs.602015

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AAAX-ray2.20C1-118[»]
ProteinModelPortaliP58546
SMRiP58546
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126455, 35 interactors
DIPiDIP-50234N
IntActiP58546, 19 interactors
STRINGi9606.ENSP00000376800

PTM databases

iPTMnetiP58546
PhosphoSitePlusiP58546

Polymorphism and mutation databases

BioMutaiMTPN
DMDMi20138912

2D gel databases

OGPiP58546

Proteomic databases

EPDiP58546
PaxDbiP58546
PeptideAtlasiP58546
PRIDEiP58546
ProteomicsDBi57087
TopDownProteomicsiP58546

Protocols and materials databases

DNASUi136319
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393085; ENSP00000376800; ENSG00000105887
GeneIDi136319
KEGGihsa:136319

Organism-specific databases

CTDi136319
DisGeNETi136319
EuPathDBiHostDB:ENSG00000105887.10
GeneCardsiMTPN
HGNCiHGNC:15667 MTPN
HPAiHPA019735
MIMi606484 gene
neXtProtiNX_P58546
OpenTargetsiENSG00000105887
PharmGKBiPA31271
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4214 Eukaryota
ENOG4111U90 LUCA
GeneTreeiENSGT00430000031071
HOGENOMiHOG000276399
HOVERGENiHBG019067
InParanoidiP58546
OMAiTALIDCT
OrthoDBiEOG091G0Y4J
PhylomeDBiP58546
TreeFamiTF327387

Miscellaneous databases

ChiTaRSiMTPN human
EvolutionaryTraceiP58546
GeneWikiiMTPN
GenomeRNAii136319
PROiPR:P58546
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105887 Expressed in 101 organ(s), highest expression level in caudate nucleus
CleanExiHS_MTPN
ExpressionAtlasiP58546 baseline and differential
GenevisibleiP58546 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMTPN_HUMAN
AccessioniPrimary (citable) accession number: P58546
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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