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Entry version 139 (02 Jun 2021)
Sequence version 1 (23 Jan 2002)
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Protein

Small integral membrane protein 11A

Gene

SMIM11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P58511

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small integral membrane protein 11AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMIM11AImported
Synonyms:C21orf51Imported, FAM165BImported, SMIM11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1293, SMIM11A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P58511

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000205670.10
HostDB:ENSG00000273590.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 32HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54065

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162387008

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P58511, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SMIM11A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000795171 – 58Small integral membrane protein 11AAdd BLAST58

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P58511

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P58511

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P58511

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P58511

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P58511

PeptideAtlas

More...
PeptideAtlasi
P58511

PRoteomics IDEntifications database

More...
PRIDEi
P58511

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57082

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P58511

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P58511

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P58511

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, spleen, liver, stomach, muscle, lung, testis, skin, PBL and bone marrow.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205670, Expressed in brain and 115 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P58511, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000205670, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119872, 14 interactors

Protein interaction database and analysis system

More...
IntActi
P58511, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382234

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P58511, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili29 – 58Sequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMIM11 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SFJD, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00620000089398

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_196183_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P58511

Identification of Orthologs from Complete Genome Data

More...
OMAi
HFPLLLY

Database of Orthologous Groups

More...
OrthoDBi
1624864at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P58511

TreeFam database of animal gene trees

More...
TreeFami
TF330784

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028023, SMIM11A
IPR042125, SMIM11A/B

The PANTHER Classification System

More...
PANTHERi
PTHR35975, PTHR35975, 1 hit
PTHR35975:SF1, PTHR35975:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14981, FAM165, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P58511-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNWKVLEHVP LLLYILAAKT LILCLTFAGV KMYQRKRLEA KQQKLEAERK

KQSEKKDN
Length:58
Mass (Da):6,886
Last modified:January 23, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i902E0799AD6E5854
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05406651K → R. Corresponds to variant dbSNP:rs34016792Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY033902 mRNA Translation: AAK68720.1
AY081144 mRNA Translation: AAL91138.1
AP000320 Genomic DNA No translation available.
AP000321 Genomic DNA No translation available.
AP000322 Genomic DNA No translation available.
BC015596 mRNA Translation: AAH15596.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33550.1

NCBI Reference Sequences

More...
RefSeqi
NP_001300621.1, NM_001313692.1
NP_478062.1, NM_058182.4
XP_016883692.1, XM_017028203.1
XP_016883693.1, XM_017028204.1
XP_016883694.1, XM_017028205.1
XP_016883886.1, XM_017028397.1
XP_016883887.1, XM_017028398.1
XP_016883888.1, XM_017028399.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000399292; ENSP00000382231; ENSG00000205670
ENST00000399295; ENSP00000382234; ENSG00000205670
ENST00000474455; ENSP00000498771; ENSG00000205670
ENST00000652570; ENSP00000499160; ENSG00000205670

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102723553
54065

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:102723553
hsa:54065

UCSC genome browser

More...
UCSCi
uc002ytu.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033902 mRNA Translation: AAK68720.1
AY081144 mRNA Translation: AAL91138.1
AP000320 Genomic DNA No translation available.
AP000321 Genomic DNA No translation available.
AP000322 Genomic DNA No translation available.
BC015596 mRNA Translation: AAH15596.1
CCDSiCCDS33550.1
RefSeqiNP_001300621.1, NM_001313692.1
NP_478062.1, NM_058182.4
XP_016883692.1, XM_017028203.1
XP_016883693.1, XM_017028204.1
XP_016883694.1, XM_017028205.1
XP_016883886.1, XM_017028397.1
XP_016883887.1, XM_017028398.1
XP_016883888.1, XM_017028399.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119872, 14 interactors
IntActiP58511, 5 interactors
STRINGi9606.ENSP00000382234

PTM databases

iPTMnetiP58511
PhosphoSitePlusiP58511

Genetic variation databases

BioMutaiSMIM11A

Proteomic databases

EPDiP58511
jPOSTiP58511
MassIVEiP58511
MaxQBiP58511
PaxDbiP58511
PeptideAtlasiP58511
PRIDEiP58511
ProteomicsDBi57082
TopDownProteomicsiP58511

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
68567, 2 antibodies

The DNASU plasmid repository

More...
DNASUi
54065

Genome annotation databases

EnsembliENST00000399292; ENSP00000382231; ENSG00000205670
ENST00000399295; ENSP00000382234; ENSG00000205670
ENST00000474455; ENSP00000498771; ENSG00000205670
ENST00000652570; ENSP00000499160; ENSG00000205670
GeneIDi102723553
54065
KEGGihsa:102723553
hsa:54065
UCSCiuc002ytu.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
102723553
54065
DisGeNETi54065

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SMIM11A
HGNCiHGNC:1293, SMIM11A
HPAiENSG00000205670, Low tissue specificity
neXtProtiNX_P58511
PharmGKBiPA162387008
VEuPathDBiHostDB:ENSG00000205670.10
HostDB:ENSG00000273590.4

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SFJD, Eukaryota
GeneTreeiENSGT00620000089398
HOGENOMiCLU_196183_0_0_1
InParanoidiP58511
OMAiHFPLLLY
OrthoDBi1624864at2759
PhylomeDBiP58511
TreeFamiTF330784

Enzyme and pathway databases

PathwayCommonsiP58511

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
102723553, 0 hits in 4 CRISPR screens
54065, 6 hits in 637 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SMIM11A, human
PharosiP58511, Tdark

Protein Ontology

More...
PROi
PR:P58511
RNActiP58511, protein

Gene expression databases

BgeeiENSG00000205670, Expressed in brain and 115 other tissues
GenevisibleiP58511, HS

Family and domain databases

InterProiView protein in InterPro
IPR028023, SMIM11A
IPR042125, SMIM11A/B
PANTHERiPTHR35975, PTHR35975, 1 hit
PTHR35975:SF1, PTHR35975:SF1, 1 hit
PfamiView protein in Pfam
PF14981, FAM165, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSI11A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58511
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: June 2, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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