UniProtKB - P58504 (KA102_CENNO)
Protein
Potassium channel toxin alpha-KTx 10.2
Gene
N/A
Organism
Centruroides noxius (Mexican scorpion)
Status
Functioni
Blocks Shaker B potassium-channels (Kv1.1/KCNA1 sub-family).1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 21 | Basic residue of the functional dyadBy similarity | 1 | |
Sitei | 30 | Aromatic residue of the functional dyadBy similarity | 1 |
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel toxin alpha-KTx 10.2Alternative name(s): Cobatoxin-21 Publication Short name: CoTx21 Publication |
Organismi | Centruroides noxius (Mexican scorpion) |
Taxonomic identifieri | 6878 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000044907 | 1 – 32 | Potassium channel toxin alpha-KTx 10.21 PublicationAdd BLAST | 32 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 3 ↔ 22 | By similarity | ||
Disulfide bondi | 8 ↔ 12 | By similarity | ||
Disulfide bondi | 27 ↔ 29 | By similarity | ||
Modified residuei | 32 | Tyrosine amideBy similarity | 1 |
Keywords - PTMi
Amidation, Disulfide bondProteomic databases
PRIDEi | P58504 |
Expressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
3D structure databases
ProteinModelPortali | P58504 |
SMRi | P58504 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 10 subfamily.Curated
Family and domain databases
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138 SCORP_SHORT_TOXIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Similar proteinsi
Cross-referencesi
3D structure databases
ProteinModelPortali | P58504 |
SMRi | P58504 |
ModBasei | Search... |
MobiDBi | Search... |
Proteomic databases
PRIDEi | P58504 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138 SCORP_SHORT_TOXIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | KA102_CENNO | |
Accessioni | P58504Primary (citable) accession number: P58504 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 19, 2001 |
Last sequence update: | December 19, 2001 | |
Last modified: | May 23, 2018 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families