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Protein

PAX3- and PAX7-binding protein 1

Gene

Paxbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processMyogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
PAX3- and PAX7-binding protein 1
Short name:
PAX3/7BP
Alternative name(s):
GC-rich sequence DNA-binding factor 1
Gene namesi
Name:Paxbp1
Synonyms:Gcfc, Gcfc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1914617 Paxbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874401 – 919PAX3- and PAX7-binding protein 1Add BLAST919

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineBy similarity1
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei160PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei297PhosphoserineCombined sources1
Modified residuei559PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei565PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP58501
MaxQBiP58501
PaxDbiP58501
PeptideAtlasiP58501
PRIDEiP58501

PTM databases

iPTMnetiP58501
PhosphoSitePlusiP58501

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues tested including skeletal muscle. Expressed in primary myoblasts.1 Publication

Gene expression databases

BgeeiENSMUSG00000022974 Expressed in 314 organ(s), highest expression level in cerebellum
CleanExiMM_1810007M14RIK
ExpressionAtlasiP58501 baseline and differential
GenevisibleiP58501 MM

Interactioni

Subunit structurei

Interacts with PAX3 and PAX7. Interacts with WDR5; associates with a histone methyltransferase (HMT) complex composed at least of RBBP5, ASH2L, SET1, SET2 and KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4 through direct interaction with WDR5.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP58501, 2 interactors
MINTiP58501
STRINGi10090.ENSMUSP00000113835

Structurei

3D structure databases

SMRiP58501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni380 – 560Necessary and sufficient for interaction with PAX71 PublicationAdd BLAST181

Sequence similaritiesi

Belongs to the GCF family.Curated

Phylogenomic databases

eggNOGiKOG2136 Eukaryota
ENOG410YU43 LUCA
GeneTreeiENSGT00390000000455
HOGENOMiHOG000043757
HOVERGENiHBG005817
InParanoidiP58501
KOiK13211
OMAiFTPHDSE
OrthoDBiEOG091G080I
TreeFamiTF315109

Family and domain databases

InterProiView protein in InterPro
IPR012890 GCFC
IPR022783 GCFC_dom
PANTHERiPTHR12214 PTHR12214, 1 hit
PfamiView protein in Pfam
PF07842 GCFC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P58501-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRKARRVNV RKRNDSEEEE RERDEEQEPP PLLPPPASGE EPGPGGGDRA
60 70 80 90 100
PAGESLLGPG PLPPPPSAHH PGLGAEAGGG ISGGAEPGNG LKPRKRPREN
110 120 130 140 150
KEVPRASLLS FQDEEEENEE VFKVKKSSYS KKIVKLLKKE YKEDLEKSKI
160 170 180 190 200
KTELNTAADS DQPLDKTCHA KDTNPEDGVV ISEHGEDEMD MESEKEEEKP
210 220 230 240 250
KAGGAFSNAL SSLNVLRPGE IPDAAFIHAA RKKRQLAREL GDFTPHDSEP
260 270 280 290 300
GKGRLVREDE NDASDDEDDD EKRRIVFSVK EKSQRQKIAE EIGIEGSDDD
310 320 330 340 350
ALVTGEQDEE LSRWEQEQIR KGINIPQVQA SQPSEVNVYY QNTYQTMPYG
360 370 380 390 400
ASYGIPYSYT AYGSSDAKSQ KTDNTVPFKT PSNEMAPVTI DLVKRQLKDR
410 420 430 440 450
LDSMKELHKT NQQQHEKHLQ SRVDSTRAIE RLEGSSGGIG ERYKFLQEMR
460 470 480 490 500
GYVQDLLECF SEKVPLINEL ESAIHQLYKQ RASRLVQRRQ DDIKDESSEF
510 520 530 540 550
SSHSNKALMA PNLDSFGRDR ALYQEHAKRR IAEREARRTR RRQAREQTGQ
560 570 580 590 600
MADHLEGLSS DDEETSTDIT NFNLEKDRIL KESSKVFEDV LESFYSIDCI
610 620 630 640 650
KAQFEAWRSK YYMSYKDAYI GLCLPKLFNP LIRLQLLTWT PLEAKCRDFE
660 670 680 690 700
TMLWFESLLF YGCEDREQEK DEADVALLPT IVEKVILPKL TVIAETMWDP
710 720 730 740 750
FSTTQTSRMV GITMKLINGY PSVVNADNKN TQVYLKALLL RMRRTLDDDV
760 770 780 790 800
FMPLYPKNVL ENKNSGPYLF FQRQFWSSVK LLGNFLQWYG IFSNKTLQEL
810 820 830 840 850
SIDGLLNRYI LMAFQNSEYG DDSIRKAQNV INCFPKQWFV NLKGERTISQ
860 870 880 890 900
LENFCRYLVH LADTIYRNSI GCSDVEKRNA RENIKQIVKL LASVRALDHA
910
ISVASDHNVK EVKSLIEGK
Length:919
Mass (Da):104,836
Last modified:May 1, 2013 - v3
Checksum:iB87DB648782A1CB6
GO
Isoform 2 (identifier: P58501-2) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     505-513: NKALMAPNL → SQSILKIKL
     514-919: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:513
Mass (Da):57,526
Checksum:i86383AAC32552328
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6YY19F6YY19_MOUSE
PAX3- and PAX7-binding protein 1
Paxbp1 Gcfc1
450Annotation score:
F6YS88F6YS88_MOUSE
PAX3- and PAX7-binding protein 1
Paxbp1 Gcfc1
36Annotation score:

Sequence cautioni

The sequence AAH14838 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAH27145 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH27145 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAB24988 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAB27645 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70H → N in AAK68725 (PubMed:11707072).Curated1
Sequence conflicti70H → N in AAK68726 (PubMed:11707072).Curated1
Sequence conflicti82S → P in AAK68725 (PubMed:11707072).Curated1
Sequence conflicti82S → P in AAK68726 (PubMed:11707072).Curated1
Sequence conflicti505 – 506NK → SQ in AAK68725 (PubMed:11707072).Curated2
Isoform 2 (identifier: P58501-2)
Sequence conflicti510K → E in BAB24988 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004268505 – 513NKALMAPNL → SQSILKIKL in isoform 2. 3 Publications9
Alternative sequenceiVSP_004269514 – 919Missing in isoform 2. 3 PublicationsAdd BLAST406

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC141885 Genomic DNA No translation available.
AY033907 mRNA Translation: AAK68725.1
AY033908 mRNA Translation: AAK68726.1
AK007365 mRNA Translation: BAB24988.2 Sequence problems.
AK011477 mRNA Translation: BAB27645.2 Sequence problems.
BC014838 mRNA Translation: AAH14838.2 Sequence problems.
BC027145 mRNA Translation: AAH27145.1 Sequence problems.
CCDSiCCDS49908.1 [P58501-1]
RefSeqiNP_080386.3, NM_026110.2 [P58501-1]
UniGeneiMm.347

Genome annotation databases

EnsembliENSMUST00000118522; ENSMUSP00000113835; ENSMUSG00000022974 [P58501-1]
GeneIDi67367
KEGGimmu:67367
UCSCiuc012aih.1 mouse [P58501-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC141885 Genomic DNA No translation available.
AY033907 mRNA Translation: AAK68725.1
AY033908 mRNA Translation: AAK68726.1
AK007365 mRNA Translation: BAB24988.2 Sequence problems.
AK011477 mRNA Translation: BAB27645.2 Sequence problems.
BC014838 mRNA Translation: AAH14838.2 Sequence problems.
BC027145 mRNA Translation: AAH27145.1 Sequence problems.
CCDSiCCDS49908.1 [P58501-1]
RefSeqiNP_080386.3, NM_026110.2 [P58501-1]
UniGeneiMm.347

3D structure databases

SMRiP58501
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP58501, 2 interactors
MINTiP58501
STRINGi10090.ENSMUSP00000113835

PTM databases

iPTMnetiP58501
PhosphoSitePlusiP58501

Proteomic databases

EPDiP58501
MaxQBiP58501
PaxDbiP58501
PeptideAtlasiP58501
PRIDEiP58501

Protocols and materials databases

DNASUi67367
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118522; ENSMUSP00000113835; ENSMUSG00000022974 [P58501-1]
GeneIDi67367
KEGGimmu:67367
UCSCiuc012aih.1 mouse [P58501-1]

Organism-specific databases

CTDi94104
MGIiMGI:1914617 Paxbp1

Phylogenomic databases

eggNOGiKOG2136 Eukaryota
ENOG410YU43 LUCA
GeneTreeiENSGT00390000000455
HOGENOMiHOG000043757
HOVERGENiHBG005817
InParanoidiP58501
KOiK13211
OMAiFTPHDSE
OrthoDBiEOG091G080I
TreeFamiTF315109

Miscellaneous databases

ChiTaRSiPaxbp1 mouse
PROiPR:P58501
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022974 Expressed in 314 organ(s), highest expression level in cerebellum
CleanExiMM_1810007M14RIK
ExpressionAtlasiP58501 baseline and differential
GenevisibleiP58501 MM

Family and domain databases

InterProiView protein in InterPro
IPR012890 GCFC
IPR022783 GCFC_dom
PANTHERiPTHR12214 PTHR12214, 1 hit
PfamiView protein in Pfam
PF07842 GCFC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAXB1_MOUSE
AccessioniPrimary (citable) accession number: P58501
Secondary accession number(s): E9QNN9
, Q78XY2, Q8R2W3, Q9CRB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: May 1, 2013
Last modified: September 12, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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