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Protein

Cycloviolacin-O2

Gene
N/A
Organism
Viola odorata (Sweet violet)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably participates in a plant defense mechanism. Has strong cytotoxic activity against a variety of drug-resistant and drug-sensitive human tumor cell lines, and against primary chronic lymphocytic leukemia and ovarian carcinoma cells. Has weaker cytotoxic activity against normal lymphocytes. Has hemolytic activity.PROSITE-ProRule annotation2 Publications

Caution

This peptide is cyclic. The start position was chosen by similarity to OAK1 (kalata-B1) for which the DNA sequence is known.Curated

GO - Biological processi

  • defense response Source: UniProtKB
  • hemolysis in other organism Source: UniProtKB-KW

Keywordsi

Biological processCytolysis, Hemolysis, Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Cycloviolacin-O2
OrganismiViola odorata (Sweet violet)
Taxonomic identifieri97441 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesViolaceaeViola

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000436101 – 30Cycloviolacin-O2Add BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki1 ↔ 30Cyclopeptide (Gly-Asn)
Disulfide bondi4 ↔ 20
Disulfide bondi8 ↔ 22
Disulfide bondi13 ↔ 27

Post-translational modificationi

This is a cyclic peptide.

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed in leaves, petals, petioles, roots and runners (at protein level).1 Publication

Structurei

Secondary structure

130
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP58434
SMRiP58434
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58434

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Belongs to the cyclotide family. Bracelet subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR005535 Cyclotide
IPR012323 Cyclotide_bracelet_CS
IPR036146 Cyclotide_sf
PfamiView protein in Pfam
PF03784 Cyclotide, 1 hit
PIRSFiPIRSF037891 Cycloviolacin, 1 hit
SUPFAMiSSF57038 SSF57038, 1 hit
PROSITEiView protein in PROSITE
PS51052 CYCLOTIDE, 1 hit
PS60008 CYCLOTIDE_BRACELET, 1 hit

Sequencei

Sequence statusi: Complete.

P58434-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30
GIPCGESCVW IPCISSAIGC SCKSKVCYRN
Length:30
Mass (Da):3,165
Last modified:December 5, 2001 - v1
Checksum:i19D19A52EACD5FE5
GO

Mass spectrometryi

Molecular mass is 3138.4 Da from positions 1 - 30. Determined by MALDI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KCGNMR-A1-30[»]
2KNMNMR-A1-30[»]
2KNNNMR-A1-30[»]
ProteinModelPortaliP58434
SMRiP58434
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP58434

Family and domain databases

InterProiView protein in InterPro
IPR005535 Cyclotide
IPR012323 Cyclotide_bracelet_CS
IPR036146 Cyclotide_sf
PfamiView protein in Pfam
PF03784 Cyclotide, 1 hit
PIRSFiPIRSF037891 Cycloviolacin, 1 hit
SUPFAMiSSF57038 SSF57038, 1 hit
PROSITEiView protein in PROSITE
PS51052 CYCLOTIDE, 1 hit
PS60008 CYCLOTIDE_BRACELET, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYO2_VIOOD
AccessioniPrimary (citable) accession number: P58434
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: November 22, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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