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Protein

Frizzled-5

Gene

fzd5

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).By similarityCurated

GO - Molecular functioni

GO - Biological processi

  • camera-type eye development Source: AgBase
  • neuron development Source: AgBase
  • regulation of cell differentiation Source: AgBase
  • regulation of cell proliferation Source: AgBase

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-5
Short name:
Fz-5
Short name:
Xfz5
Gene namesi
Name:fzd5
Synonyms:fz5
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865299 fzd5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 220ExtracellularSequence analysisAdd BLAST194
Transmembranei221 – 241Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini242 – 257CytoplasmicSequence analysisAdd BLAST16
Transmembranei258 – 278Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini279 – 301ExtracellularSequence analysisAdd BLAST23
Transmembranei302 – 322Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini323 – 343CytoplasmicSequence analysisAdd BLAST21
Transmembranei344 – 364Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini365 – 387ExtracellularSequence analysisAdd BLAST23
Transmembranei388 – 408Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini409 – 434CytoplasmicSequence analysisAdd BLAST26
Transmembranei435 – 455Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini456 – 483ExtracellularSequence analysisAdd BLAST28
Transmembranei484 – 504Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini505 – 559CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001299227 – 559Frizzled-5Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 94PROSITE-ProRule annotation
Disulfide bondi41 ↔ 87PROSITE-ProRule annotation
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi78 ↔ 116PROSITE-ProRule annotation
Disulfide bondi105 ↔ 146PROSITE-ProRule annotation
Disulfide bondi109 ↔ 133PROSITE-ProRule annotation
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi468N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP58421

Expressioni

Tissue specificityi

Expressed in retina.1 Publication

Developmental stagei

First detected at the late neurula stage in retinal primordia. Throughout the tailbud stage, expressed exclusively in the neural retina within the optic vesicles. During tadpole stage, expression becomes restricted to the ciliary marginal zone.1 Publication

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP58421
SMRiP58421
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 149FZPROSITE-ProRule annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi507 – 512Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi557 – 559PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi152 – 157Poly-Thr6

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006977
KOiK02375

Family and domain databases

CDDicd07460 CRD_FZ5, 1 hit
Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR037441 FZ5_CRD
IPR017981 GPCR_2-like
PANTHERiPTHR11309 PTHR11309, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSFRSGVFA LSFVVLLLDY FAPAQAASKA IVCQEITVPM CKGIGYNHTY
60 70 80 90 100
MPNQFNHDTQ DEAGMEVHQF WPLVVIQCSL DLKFFLCSMY TPICLPDYRK
110 120 130 140 150
PLPPCRSVCE RAKAGCSPLM RKYGFAWPER MNCDRLPEHG DPDTLCMYYN
160 170 180 190 200
WTETTTTLPP THPPKVKTPT SDCDGVCKCR EPFVSITRES HPLYNRIKTG
210 220 230 240 250
QVPNCAMPCF QPYFTQDEKM FVTFWIGLWS ILCFISTFTT VATFLIDMER
260 270 280 290 300
FRYPERPIIF LSACYLFVSI GYVVRLIVGH ENVACNKDHI HYETTGPALC
310 320 330 340 350
TIVFLLIYFF GMASSIWWVI LTFTWFLAAG MKWGNEAIAS YSQYFHMAAW
360 370 380 390 400
LIPSVKSIAV LALSSVDGDP VAGICYVGNQ NLDNLRGFVL APLVVYLFSG
410 420 430 440 450
TMFLLAGFVS LFRIRSVIKQ GGTKTDKLEK LMIRIGIFSV LYTVPATIVV
460 470 480 490 500
ACYIYEQHYR EHWEKTHNCS CPGDKQRYRP DYAVFMLKYL MCLVVGITSG
510 520 530 540 550
VWIWSGKTLE SWKRFTGRCC RNSKPINASA YSEASRALTP RTGLSNLTLP

HKQVPLSHV
Length:559
Mass (Da):63,518
Last modified:December 5, 2001 - v1
Checksum:i581EB243FCB954B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF300716 mRNA Translation: AAK51688.1
RefSeqiNP_001079217.1, NM_001085748.1
UniGeneiXl.11966

Genome annotation databases

GeneIDi373834
KEGGixla:373834

Similar proteinsi

Entry informationi

Entry nameiFZD5_XENLA
AccessioniPrimary (citable) accession number: P58421
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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