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Protein

Neurexophilin-1

Gene

NXPH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.Curated

GO - Molecular functioni

  • signaling receptor binding Source: GO_Central

Enzyme and pathway databases

SIGNORiP58417

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-1
Gene namesi
Name:NXPH1
Synonyms:NPH1
ORF Names:Nbla00697
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122584.12
HGNCiHGNC:20693 NXPH1
MIMi604639 gene
neXtProtiNX_P58417

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi30010
OpenTargetsiENSG00000122584
PharmGKBiPA134961263

Polymorphism and mutation databases

BioMutaiNXPH1
DMDMi17433155

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002005922 – 271Neurexophilin-1Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP58417
PeptideAtlasiP58417
PRIDEiP58417
ProteomicsDBi57073

PTM databases

iPTMnetiP58417
PhosphoSitePlusiP58417

Expressioni

Gene expression databases

BgeeiENSG00000122584 Expressed in 73 organ(s), highest expression level in right adrenal gland cortex
CleanExiHS_NXPH1
ExpressionAtlasiP58417 baseline and differential
GenevisibleiP58417 HS

Organism-specific databases

HPAiHPA020062

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119028, 13 interactors
STRINGi9606.ENSP00000384551

Structurei

3D structure databases

ProteinModelPortaliP58417
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 97IIAdd BLAST76
Regioni98 – 176IIIAdd BLAST79
Regioni177 – 185IV (linker domain)9
Regioni186 – 271V (Cys-rich)Add BLAST86

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJV8 Eukaryota
ENOG410YYWH LUCA
GeneTreeiENSGT00390000015950
HOGENOMiHOG000261694
HOVERGENiHBG052706
InParanoidiP58417
KOiK16656
OMAiFQVTCAN
OrthoDBiEOG091G0GC5
PhylomeDBiP58417
TreeFamiTF333047

Family and domain databases

InterProiView protein in InterPro
IPR010450 Nxph
IPR026845 NXPH/NXPE
PANTHERiPTHR17103 PTHR17103, 1 hit
PfamiView protein in Pfam
PF06312 Neurexophilin, 1 hit
PIRSFiPIRSF038019 Neurexophilin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P58417-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQAACWYVLF LLQPTVYLVT CANLTNGGKS ELLKSGSSKS TLKHIWTESS
60 70 80 90 100
KDLSISRLLS QTFRGKENDT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP
110 120 130 140 150
RPRAKRRPIV KTGKFKKMFG WGDFHSNIKT VKLNLLITGK IVDHGNGTFS
160 170 180 190 200
VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ QTVIDAKDSK SFNCRIEYEK
210 220 230 240 250
VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI YISFYSTDYK
260 270
LVQKVCPDYN YHSDTPYFPS G
Length:271
Mass (Da):31,082
Last modified:December 5, 2001 - v1
Checksum:i140C6C7DE1126B27
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GMM9R4GMM9_HUMAN
Neurexophilin
NXPH1
253Annotation score:
C9JE46C9JE46_HUMAN
Neurexophilin-1
NXPH1
139Annotation score:
C9JPD0C9JPD0_HUMAN
Neurexophilin-1
NXPH1
143Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146N → S in BAC03713 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047362 mRNA Translation: BAB69044.1
AK091655 mRNA Translation: BAC03713.1
AC004457 Genomic DNA No translation available.
AC004613 Genomic DNA No translation available.
AC004861 Genomic DNA No translation available.
BC047505 mRNA Translation: AAH47505.1
CCDSiCCDS47540.1
RefSeqiNP_689958.1, NM_152745.2
UniGeneiHs.487564

Genome annotation databases

EnsembliENST00000405863; ENSP00000384551; ENSG00000122584
GeneIDi30010
KEGGihsa:30010

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047362 mRNA Translation: BAB69044.1
AK091655 mRNA Translation: BAC03713.1
AC004457 Genomic DNA No translation available.
AC004613 Genomic DNA No translation available.
AC004861 Genomic DNA No translation available.
BC047505 mRNA Translation: AAH47505.1
CCDSiCCDS47540.1
RefSeqiNP_689958.1, NM_152745.2
UniGeneiHs.487564

3D structure databases

ProteinModelPortaliP58417
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119028, 13 interactors
STRINGi9606.ENSP00000384551

PTM databases

iPTMnetiP58417
PhosphoSitePlusiP58417

Polymorphism and mutation databases

BioMutaiNXPH1
DMDMi17433155

Proteomic databases

PaxDbiP58417
PeptideAtlasiP58417
PRIDEiP58417
ProteomicsDBi57073

Protocols and materials databases

DNASUi30010
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405863; ENSP00000384551; ENSG00000122584
GeneIDi30010
KEGGihsa:30010

Organism-specific databases

CTDi30010
DisGeNETi30010
EuPathDBiHostDB:ENSG00000122584.12
GeneCardsiNXPH1
HGNCiHGNC:20693 NXPH1
HPAiHPA020062
MIMi604639 gene
neXtProtiNX_P58417
OpenTargetsiENSG00000122584
PharmGKBiPA134961263
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJV8 Eukaryota
ENOG410YYWH LUCA
GeneTreeiENSGT00390000015950
HOGENOMiHOG000261694
HOVERGENiHBG052706
InParanoidiP58417
KOiK16656
OMAiFQVTCAN
OrthoDBiEOG091G0GC5
PhylomeDBiP58417
TreeFamiTF333047

Enzyme and pathway databases

SIGNORiP58417

Miscellaneous databases

GeneWikiiNXPH1
GenomeRNAii30010
PROiPR:P58417
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122584 Expressed in 73 organ(s), highest expression level in right adrenal gland cortex
CleanExiHS_NXPH1
ExpressionAtlasiP58417 baseline and differential
GenevisibleiP58417 HS

Family and domain databases

InterProiView protein in InterPro
IPR010450 Nxph
IPR026845 NXPH/NXPE
PANTHERiPTHR17103 PTHR17103, 1 hit
PfamiView protein in Pfam
PF06312 Neurexophilin, 1 hit
PIRSFiPIRSF038019 Neurexophilin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNXPH1_HUMAN
AccessioniPrimary (citable) accession number: P58417
Secondary accession number(s): Q8NB31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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