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Protein

Neurexin-2-beta

Gene

NRXN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.

GO - Molecular functioni

  • cell adhesion molecule binding Source: BHF-UCL
  • neuroligin family protein binding Source: BHF-UCL
  • transmembrane signaling receptor activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-2-beta
Alternative name(s):
Neurexin II-beta
Gene namesi
Name:NRXN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110076.18
HGNCiHGNC:8009 NRXN2
MIMi600566 gene
neXtProtiNX_P58401

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini51 – 590ExtracellularSequence analysisAdd BLAST540
Transmembranei591 – 611HelicalSequence analysisAdd BLAST21
Topological domaini612 – 666CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9379
OpenTargetsiENSG00000110076
PharmGKBiPA31787

Polymorphism and mutation databases

BioMutaiKIAA0232
DMDMi17368287

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 50By similarityAdd BLAST50
ChainiPRO_000001949751 – 666Neurexin-2-betaAdd BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiP58401
PRIDEiP58401
ProteomicsDBi57072
TopDownProteomicsiP58401-1 [P58401-1]

Expressioni

Gene expression databases

BgeeiENSG00000110076 Expressed in 160 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_NRXN2
ExpressionAtlasiP58401 baseline and differential
GenevisibleiP58401 HS

Interactioni

Subunit structurei

The cytoplasmic C-terminal region binds to CASK. Specific isoforms bind alpha-dystroglycan and neuroligins NLGN1, NLGN2 and NLGN3 (By similarity). Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114780, 6 interactors
IntActiP58401, 1 interactor
MINTiP58401

Structurei

Secondary structure

1666
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP58401
SMRiP58401
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 299Laminin G-likePROSITE-ProRule annotationAdd BLAST209

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi322 – 325Poly-Thr4
Compositional biasi328 – 331Poly-Thr4
Compositional biasi398 – 401Poly-Pro4
Compositional biasi598 – 601Poly-Ala4

Domaini

Alternative splicing in the laminin G-like domain regulates binding to alpha-dystroglycan.

Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991
HOGENOMiHOG000230482
HOVERGENiHBG052670

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 1 hit
PfamiView protein in Pfam
PF02210 Laminin_G_2, 1 hit
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00282 LamG, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50025 LAM_G_DOMAIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. Additional isoforms produced by alternative splicing seem to exist.
Isoform 1b (identifier: P58401-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPGGSGPGG CPRRPPALAG PLPPPPPPPP PPLLPLLPLL LLLLLGAAEG
60 70 80 90 100
ARVSSSLSTT HHVHHFHSKH GTVPIAINRM PFLTRGGHAG TTYIFGKGGA
110 120 130 140 150
LITYTWPPND RPSTRMDRLA VGFSTHQRSA VLVRVDSASG LGDYLQLHID
160 170 180 190 200
QGTVGVIFNV GTDDITIDEP NAIVSDGKYH VVRFTRSGGN ATLQVDSWPV
210 220 230 240 250
NERYPAGNFD NERLAIARQR IPYRLGRVVD EWLLDKGRQL TIFNSQAAIK
260 270 280 290 300
IGGRDQGRPF QGQVSGLYYN GLKVLALAAE SDPNVRTEGH LRLVGEGPSV
310 320 330 340 350
LLSAETTATT LLADMATTIM ETTTTMATTT TRRGRSPTLR DSTTQNTDDL
360 370 380 390 400
LVASAECPSD DEDLEECEPS TGGELILPII TEDSLDPPPV ATRSPFVPPP
410 420 430 440 450
PTFYPFLTGV GATQDTLPPP AARRPPSGGP CQAERDDSDC EEPIEASGFA
460 470 480 490 500
SGEVFDSSLP PTDDEDFYTT FPLVTDRTTL LSPRKPAPRP NLRTDGATGA
510 520 530 540 550
PGVLFAPSAP APNLPAGKMN HRDPLQPLLE NPPLGPGAPT SFEPRRPPPL
560 570 580 590 600
RPGVTSAPGF PHLPTANPTG PGERGPPGAV EVIRESSSTT GMVVGIVAAA
610 620 630 640 650
ALCILILLYA MYKYRNRDEG SYQVDQSRNY ISNSAQSNGA VVKEKAPAAP
660
KTPSKAKKNK DKEYYV
Length:666
Mass (Da):70,927
Last modified:November 16, 2001 - v1
Checksum:iFD0B2FD353F63C6C
GO
Isoform 1a (identifier: Q9P2S2-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9P2S2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,712
Mass (Da):184,982
GO
Isoform 2a (identifier: Q9P2S2-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-2B
The sequence of this isoform can be found in the external entry Q9P2S2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,642
Mass (Da):177,293
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001092 Genomic DNA No translation available.
AC044790 Genomic DNA No translation available.
CCDSiCCDS8078.1 [P58401-1]
RefSeqiNP_620063.1, NM_138734.2 [P58401-1]
UniGeneiHs.372938

Genome annotation databases

EnsembliENST00000301894; ENSP00000301894; ENSG00000110076 [P58401-1]
GeneIDi9379
UCSCiuc001oap.3 human [P58401-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001092 Genomic DNA No translation available.
AC044790 Genomic DNA No translation available.
CCDSiCCDS8078.1 [P58401-1]
RefSeqiNP_620063.1, NM_138734.2 [P58401-1]
UniGeneiHs.372938

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NXRX-ray1.90B659-666[»]
ProteinModelPortaliP58401
SMRiP58401
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114780, 6 interactors
IntActiP58401, 1 interactor
MINTiP58401

Polymorphism and mutation databases

BioMutaiKIAA0232
DMDMi17368287

Proteomic databases

PeptideAtlasiP58401
PRIDEiP58401
ProteomicsDBi57072
TopDownProteomicsiP58401-1 [P58401-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301894; ENSP00000301894; ENSG00000110076 [P58401-1]
GeneIDi9379
UCSCiuc001oap.3 human [P58401-1]

Organism-specific databases

CTDi9379
DisGeNETi9379
EuPathDBiHostDB:ENSG00000110076.18
GeneCardsiNRXN2
HGNCiHGNC:8009 NRXN2
MIMi600566 gene
neXtProtiNX_P58401
OpenTargetsiENSG00000110076
PharmGKBiPA31787
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991
HOGENOMiHOG000230482
HOVERGENiHBG052670

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiNRXN2 human
GeneWikiiNRXN2
GenomeRNAii9379
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110076 Expressed in 160 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_NRXN2
ExpressionAtlasiP58401 baseline and differential
GenevisibleiP58401 HS

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 1 hit
PfamiView protein in Pfam
PF02210 Laminin_G_2, 1 hit
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00282 LamG, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50025 LAM_G_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRX2B_HUMAN
AccessioniPrimary (citable) accession number: P58401
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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