UniProtKB - P58400 (NRX1B_HUMAN)
Neurexin-1-beta
NRXN1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 141 | Calcium | 1 | |
Metal bindingi | 158 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 240 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 242 | Calcium | 1 |
GO - Molecular functioni
- calcium-dependent protein binding Source: BHF-UCL
- cell adhesion molecule binding Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- neuroligin family protein binding Source: ARUK-UCL
- signaling receptor binding Source: BHF-UCL
- transmembrane signaling receptor activity Source: BHF-UCL
- type 1 fibroblast growth factor receptor binding Source: ARUK-UCL
GO - Biological processi
- adult behavior Source: BHF-UCL
- angiogenesis Source: UniProtKB
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
- cellular response to calcium ion Source: ARUK-UCL
- cerebellar granule cell differentiation Source: BHF-UCL
- establishment of protein localization Source: BHF-UCL
- gamma-aminobutyric acid receptor clustering Source: BHF-UCL
- gephyrin clustering involved in postsynaptic density assembly Source: BHF-UCL
- guanylate kinase-associated protein clustering Source: BHF-UCL
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
- learning Source: BHF-UCL
- negative regulation of filopodium assembly Source: BHF-UCL
- negative regulation of gene expression Source: ARUK-UCL
- neuroligin clustering involved in postsynaptic membrane assembly Source: BHF-UCL
- neuronal signal transduction Source: BHF-UCL
- neuron cell-cell adhesion Source: BHF-UCL
- neuron projection development Source: ARUK-UCL
- NMDA glutamate receptor clustering Source: BHF-UCL
- positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
- positive regulation of excitatory postsynaptic potential Source: BHF-UCL
- positive regulation of fibroblast growth factor receptor signaling pathway Source: ARUK-UCL
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of peptidyl-serine phosphorylation Source: ARUK-UCL
- positive regulation of presynaptic active zone assembly Source: BHF-UCL
- positive regulation of protein kinase A signaling Source: ARUK-UCL
- positive regulation of protein kinase B signaling Source: ARUK-UCL
- positive regulation of protein kinase C activity Source: ARUK-UCL
- positive regulation of protein localization to plasma membrane Source: BHF-UCL
- positive regulation of synapse assembly Source: BHF-UCL
- positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
- postsynaptic density protein 95 clustering Source: BHF-UCL
- postsynaptic membrane assembly Source: BHF-UCL
- presynaptic membrane assembly Source: BHF-UCL
- protein-containing complex assembly involved in synapse maturation Source: BHF-UCL
- protein localization to synapse Source: BHF-UCL
- receptor localization to synapse Source: BHF-UCL
- regulation of AMPA receptor activity Source: BHF-UCL
- regulation of NMDA receptor activity Source: BHF-UCL
- signal transduction Source: BHF-UCL
- social behavior Source: BHF-UCL
- synapse assembly Source: BHF-UCL
- synaptic vesicle clustering Source: BHF-UCL
- vocalization behavior Source: BHF-UCL
Keywordsi
Biological process | Angiogenesis, Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P58400 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
SIGNORi | P58400 |
Names & Taxonomyi
Protein namesi | Recommended name: Neurexin-1-betaAlternative name(s): Neurexin I-beta |
Gene namesi | Name:NRXN1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8008, NRXN1 |
MIMi | 600565, gene |
neXtProti | NX_P58400 |
VEuPathDBi | HostDB:ENSG00000179915.21 |
Subcellular locationi
Plasma membrane
- presynaptic cell membrane By similarity; Single-pass type I membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: BHF-UCL
Nucleus
- nuclear membrane Source: BHF-UCL
Plasma Membrane
- integral component of presynaptic membrane Source: BHF-UCL
- plasma membrane Source: BHF-UCL
- presynaptic membrane Source: BHF-UCL
Other locations
- axonal growth cone Source: BHF-UCL
- cell surface Source: BHF-UCL
- endocytic vesicle Source: BHF-UCL
- neuronal cell body Source: BHF-UCL
- presynapse Source: ARUK-UCL
- vesicle Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 51 – 396 | ExtracellularSequence analysisAdd BLAST | 346 | |
Transmembranei | 397 – 417 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 418 – 472 | CytoplasmicSequence analysisAdd BLAST | 55 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 9378 |
MalaCardsi | NRXN1 |
OpenTargetsi | ENSG00000179915 |
Miscellaneous databases
Pharosi | P58400, Tbio |
Genetic variation databases
BioMutai | NRXN1 |
DMDMi | 322510054 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 50 | By similarityAdd BLAST | 50 | |
ChainiPRO_0000019493 | 51 – 472 | Neurexin-1-betaAdd BLAST | 422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | P58400 |
PeptideAtlasi | P58400 |
PRIDEi | P58400 |
ProteomicsDBi | 18162 57071 [P58400-1] |
PTM databases
iPTMneti | P58400 |
Expressioni
Gene expression databases
Bgeei | ENSG00000179915, Expressed in corpus callosum and 196 other tissues |
ExpressionAtlasi | P58400, baseline and differential |
Genevisiblei | P58400, HS |
Organism-specific databases
HPAi | ENSG00000179915, Tissue enriched (brain) |
Interactioni
Subunit structurei
The cytoplasmic C-terminal region binds to CASK. Binds NLGN1, NLGN2 and NLGN3, DAG1 (alpha-dystroglycan) and alpha-latrotoxin. Binding to neuroligins is calcium-dependent, and the binding preference ranks as follow: NLGN1 > NLGN4 >> NLGN3 > NLGN2 (By similarity).
Interacts with CBLN2 and more weakly with CBLN4 (By similarity).
Interacts with CBLN1; interaction is CBLN1 hexamer form-dependent; CBLN1-binding is calcium-independent; isoform 1b does not interact with CBLN1 (PubMed:27418511).
By similarity1 Publication(Microbial infection) Interacts with Staphylococcus aureus protein SdrC; this interaction increases S. aureus adherence to cells.
1 PublicationBinary interactionsi
Isoform 3b [P58400-1]
With | #Exp. | IntAct |
---|---|---|
Nlgn1 - isoform 1 [Q99K10-1] from Mus musculus. | 3 | EBI-16513622,EBI-15675933 |
GO - Molecular functioni
- calcium-dependent protein binding Source: BHF-UCL
- cell adhesion molecule binding Source: BHF-UCL
- neuroligin family protein binding Source: ARUK-UCL
- signaling receptor binding Source: BHF-UCL
- type 1 fibroblast growth factor receptor binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 114779, 16 interactors |
ComplexPortali | CPX-4101, NLGN1(+SSA+SSB) - NRXN1-beta(-SS4) complex [P58400-1] CPX-909, NLGN1(-SSA-SSB) - NRXN1-beta(-SS4) complex [P58400-1] |
DIPi | DIP-46402N |
IntActi | P58400, 1 interactor |
Structurei
Secondary structure
3D structure databases
SMRi | P58400 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P58400 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 91 – 289 | Laminin G-likePROSITE-ProRule annotationAdd BLAST | 199 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 205 – 234 | Essential for interaction with CBLN1; modulates interaction affinity with NLGN1, NLGN2 and NLGN3; prevents interaction with DAG1/alpha-dystroglycan; modulates interaction with alpha-latrotoxinBy similarity1 PublicationAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 29 | Gly-richPROSITE-ProRule annotationAdd BLAST | 21 | |
Compositional biasi | 300 – 343 | Thr-richPROSITE-ProRule annotationAdd BLAST | 44 | |
Compositional biasi | 404 – 407 | Poly-Ala | 4 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00940000154292 |
Family and domain databases
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR001791, Laminin_G IPR003585, Neurexin-like IPR027789, Syndecan/Neurexin_dom |
Pfami | View protein in Pfam PF02210, Laminin_G_2, 1 hit PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit SM00282, LamG, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50025, LAM_G_DOMAIN, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 25 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYQRMLRCGA ELGSPGGGGG GGGGGGAGGR LALLWIVPLT LSGLLGVAWG
60 70 80 90 100
ASSLGAHHIH HFHGSSKHHS VPIAIYRSPA SLRGGHAGTT YIFSKGGGQI
110 120 130 140 150
TYKWPPNDRP STRADRLAIG FSTVQKEAVL VRVDSSSGLG DYLELHIHQG
160 170 180 190 200
KIGVKFNVGT DDIAIEESNA IINDGKYHVV RFTRSGGNAT LQVDSWPVIE
210 220 230 240 250
RYPAGNNDNE RLAIARQRIP YRLGRVVDEW LLDKGRQLTI FNSQATIIIG
260 270 280 290 300
GKEQGQPFQG QLSGLYYNGL KVLNMAAEND ANIAIVGNVR LVGEVPSSMT
310 320 330 340 350
TESTATAMQS EMSTSIMETT TTLATSTARR GKPPTKEPIS QTTDDILVAS
360 370 380 390 400
AECPSDDEDI DPCEPSSGGL ANPTRAGGRE PYPGSAEVIR ESSSTTGMVV
410 420 430 440 450
GIVAAAALCI LILLYAMYKY RNRDEGSYHV DESRNYISNS AQSNGAVVKE
460 470
KQPSSAKSSN KNKKNKDKEY YV
The sequence of this isoform differs from the canonical sequence as follows:
205-234: Missing.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Computationally mapped potential isoform sequencesi
There are 25 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ERL8 | E7ERL8_HUMAN | Neurexin-1-beta | NRXN1 | 1,507 | Annotation score: | ||
A0A1D5RMU6 | A0A1D5RMU6_HUMAN | Neurexin-1-beta | NRXN1 | 1,499 | Annotation score: | ||
A0A0R4J2G7 | A0A0R4J2G7_HUMAN | Neurexin-1-beta | NRXN1 | 1,495 | Annotation score: | ||
A0A0D9SEM5 | A0A0D9SEM5_HUMAN | Neurexin-1-beta | NRXN1 | 469 | Annotation score: | ||
A0A0D9SF36 | A0A0D9SF36_HUMAN | Neurexin-1-beta | NRXN1 | 213 | Annotation score: | ||
H7BYC7 | H7BYC7_HUMAN | Neurexin-1-beta | NRXN1 | 142 | Annotation score: | ||
H0Y568 | H0Y568_HUMAN | Neurexin-1-beta | NRXN1 | 139 | Annotation score: | ||
Q08AH0 | Q08AH0_HUMAN | NRXN1 protein | NRXN1 | 198 | Annotation score: | ||
E7EQN4 | E7EQN4_HUMAN | Neurexin-1-beta | NRXN1 | 278 | Annotation score: | ||
A0A1B0GTL0 | A0A1B0GTL0_HUMAN | Neurexin-1-beta | NRXN1 | 143 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 20 | G → R in AF064842 (PubMed:9921901).Curated | 1 | |
Sequence conflicti | 46 | G → R in AF064842 (PubMed:9921901).Curated | 1 | |
Sequence conflicti | 158 | V → I in AF064842 (PubMed:9921901).Curated | 1 | |
Sequence conflicti | 288 | N → D in AF064842 (PubMed:9921901).Curated | 1 | |
Sequence conflicti | 344 | D → G in AF064842 (PubMed:9921901).Curated | 1 | |
Sequence conflicti | 415 | Y → C in AF064842 (PubMed:9921901).Curated | 1 | |
Sequence conflicti | 418 – 420 | YKY → NKC in AF064842 (PubMed:9921901).Curated | 3 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059057 | 205 – 234 | Missing in isoform 3b. Add BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF064842 mRNA No translation available. AC007462 Genomic DNA No translation available. AC007560 Genomic DNA No translation available. AC007680 Genomic DNA No translation available. AC007682 Genomic DNA No translation available. AC009234 Genomic DNA No translation available. AC010721 Genomic DNA No translation available. AC068715 Genomic DNA No translation available. AC068725 Genomic DNA No translation available. AC069550 Genomic DNA No translation available. AC078994 Genomic DNA No translation available. |
CCDSi | CCDS1845.1 [P58400-1] CCDS82446.1 [P58400-2] |
RefSeqi | NP_001317021.1, NM_001330092.1 [P58400-2] NP_620072.1, NM_138735.4 [P58400-1] |
Genome annotation databases
Ensembli | ENST00000342183; ENSP00000341184; ENSG00000179915 [P58400-1] ENST00000401710; ENSP00000385580; ENSG00000179915 [P58400-2] |
GeneIDi | 9378 |
KEGGi | hsa:9378 |
UCSCi | uc010fbp.4, human [P58400-2] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF064842 mRNA No translation available. AC007462 Genomic DNA No translation available. AC007560 Genomic DNA No translation available. AC007680 Genomic DNA No translation available. AC007682 Genomic DNA No translation available. AC009234 Genomic DNA No translation available. AC010721 Genomic DNA No translation available. AC068715 Genomic DNA No translation available. AC068725 Genomic DNA No translation available. AC069550 Genomic DNA No translation available. AC078994 Genomic DNA No translation available. |
CCDSi | CCDS1845.1 [P58400-1] CCDS82446.1 [P58400-2] |
RefSeqi | NP_001317021.1, NM_001330092.1 [P58400-2] NP_620072.1, NM_138735.4 [P58400-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3B3Q | X-ray | 2.40 | E/F | 85-296 | [»] | |
5Z8Y | X-ray | 3.40 | B/D/F/H | 86-296 | [»] | |
SMRi | P58400 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114779, 16 interactors |
ComplexPortali | CPX-4101, NLGN1(+SSA+SSB) - NRXN1-beta(-SS4) complex [P58400-1] CPX-909, NLGN1(-SSA-SSB) - NRXN1-beta(-SS4) complex [P58400-1] |
DIPi | DIP-46402N |
IntActi | P58400, 1 interactor |
PTM databases
iPTMneti | P58400 |
Genetic variation databases
BioMutai | NRXN1 |
DMDMi | 322510054 |
Proteomic databases
MassIVEi | P58400 |
PeptideAtlasi | P58400 |
PRIDEi | P58400 |
ProteomicsDBi | 18162 57071 [P58400-1] |
Protocols and materials databases
ABCDi | P58400, 2 sequenced antibodies |
Antibodypediai | 30173, 272 antibodies |
Genome annotation databases
Ensembli | ENST00000342183; ENSP00000341184; ENSG00000179915 [P58400-1] ENST00000401710; ENSP00000385580; ENSG00000179915 [P58400-2] |
GeneIDi | 9378 |
KEGGi | hsa:9378 |
UCSCi | uc010fbp.4, human [P58400-2] |
Organism-specific databases
CTDi | 9378 |
DisGeNETi | 9378 |
GeneCardsi | NRXN1 |
HGNCi | HGNC:8008, NRXN1 |
HPAi | ENSG00000179915, Tissue enriched (brain) |
MalaCardsi | NRXN1 |
MIMi | 600565, gene |
neXtProti | NX_P58400 |
OpenTargetsi | ENSG00000179915 |
VEuPathDBi | HostDB:ENSG00000179915.21 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154292 |
Enzyme and pathway databases
PathwayCommonsi | P58400 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
SIGNORi | P58400 |
Miscellaneous databases
BioGRID-ORCSi | 9378, 1 hit in 867 CRISPR screens |
ChiTaRSi | NRXN1, human |
EvolutionaryTracei | P58400 |
GeneWikii | NRXN1 |
GenomeRNAii | 9378 |
Pharosi | P58400, Tbio |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179915, Expressed in corpus callosum and 196 other tissues |
ExpressionAtlasi | P58400, baseline and differential |
Genevisiblei | P58400, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR001791, Laminin_G IPR003585, Neurexin-like IPR027789, Syndecan/Neurexin_dom |
Pfami | View protein in Pfam PF02210, Laminin_G_2, 1 hit PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit SM00282, LamG, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50025, LAM_G_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NRX1B_HUMAN | |
Accessioni | P58400Primary (citable) accession number: P58400 Secondary accession number(s): E7ETA5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | August 30, 2017 | |
Last modified: | February 10, 2021 | |
This is version 165 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families