NRXN1

Functionⁱ

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	141	Calcium	1
Metal bindingⁱ	158	Calcium; via carbonyl oxygen	1
Metal bindingⁱ	240	Calcium; via carbonyl oxygen	1
Metal bindingⁱ	242	Calcium	1

GO - Molecular functionⁱ

calcium-dependent protein binding Source: BHF-UCL
cell adhesion molecule binding Source: BHF-UCL
metal ion binding Source: UniProtKB-KW
neuroligin family protein binding Source: ARUK-UCL
signaling receptor binding Source: BHF-UCL
transmembrane signaling receptor activity Source: BHF-UCL
type 1 fibroblast growth factor receptor binding
Source: ARUK-UCL
Inferred from direct assayⁱ
- 22750515

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult behavior
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17034946
angiogenesis Source: UniProtKB
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
cellular response to calcium ion Source: ARUK-UCL
cerebellar granule cell differentiation Source: BHF-UCL
establishment of protein localization Source: BHF-UCL
gamma-aminobutyric acid receptor clustering Source: BHF-UCL
gephyrin clustering involved in postsynaptic density assembly Source: BHF-UCL
guanylate kinase-associated protein clustering Source: BHF-UCL
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
learning
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17034946
negative regulation of filopodium assembly Source: BHF-UCL
negative regulation of gene expression
Source: ARUK-UCL
Inferred from direct assayⁱ
- 26078884
neuroligin clustering involved in postsynaptic membrane assembly Source: BHF-UCL
neuronal signal transduction
Source: BHF-UCL
Traceable author statementⁱ
- 15797875
neuron cell-cell adhesion Source: BHF-UCL
neuron projection development
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 22750515
NMDA glutamate receptor clustering Source: BHF-UCL
positive regulation of ERK1 and ERK2 cascade
Source: ARUK-UCL
Inferred from direct assayⁱ
- 26078884
positive regulation of excitatory postsynaptic potential Source: BHF-UCL
positive regulation of fibroblast growth factor receptor signaling pathway
Source: ARUK-UCL
Inferred from direct assayⁱ
- 22750515
positive regulation of gene expression
Source: ARUK-UCL
Inferred from direct assayⁱ
- 26078884
positive regulation of peptidyl-serine phosphorylation
Source: ARUK-UCL
Inferred from direct assayⁱ
- 26078884
positive regulation of presynaptic active zone assembly
Source: BHF-UCL
Traceable author statementⁱ
- 15797875
positive regulation of protein kinase A signaling
Source: ARUK-UCL
Inferred from direct assayⁱ
- 26078884
positive regulation of protein kinase B signaling
Source: ARUK-UCL
Inferred from direct assayⁱ
- 26078884
positive regulation of protein kinase C activity
Source: ARUK-UCL
Inferred from direct assayⁱ
- 26078884
positive regulation of protein localization to plasma membrane Source: BHF-UCL
positive regulation of synapse assembly
Source: BHF-UCL
Traceable author statementⁱ
- 15797875
positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
postsynaptic density protein 95 clustering Source: BHF-UCL
postsynaptic membrane assembly Source: BHF-UCL
presynaptic membrane assembly Source: BHF-UCL
protein-containing complex assembly involved in synapse maturation Source: BHF-UCL
protein localization to synapse Source: BHF-UCL
receptor localization to synapse Source: BHF-UCL
regulation of AMPA receptor activity Source: BHF-UCL
regulation of NMDA receptor activity Source: BHF-UCL
signal transduction Source: BHF-UCL
social behavior
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17034946
synapse assembly Source: BHF-UCL
synaptic vesicle clustering Source: BHF-UCL
vocalization behavior
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17034946

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Angiogenesis, Cell adhesion
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6794361 Neurexins and neuroligins
SIGNORⁱ	P58400

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neurexin-1-beta Alternative name(s): Neurexin I-beta
Gene namesⁱ	Name:NRXN1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179915.21
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8008 NRXN1
MIMⁱ	600565 gene
neXtProtⁱ	NX_P58400

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	51 – 396	ExtracellularSequence analysisAdd BLAST	346
Transmembraneⁱ	397 – 417	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	418 – 472	CytoplasmicSequence analysisAdd BLAST	55

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9378
MalaCards human disease database More...MalaCardsⁱ	NRXN1
Open Targets More...OpenTargetsⁱ	ENSG00000179915

Polymorphism and mutation databases

BioMutaⁱ	FSHR
DMDMⁱ	322510054

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 50	By similarityAdd BLAST		50
ChainⁱPRO_0000019493	51 – 472	Neurexin-1-betaAdd BLAST		422

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	188	N-linked (GlcNAc...) asparagineSequence analysis		1

Post-translational modificationⁱ

Highly O-glycosylated and minor N-glycosylated.By similarity

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P58400
PRIDEⁱ	P58400
ProteomicsDBⁱ	57071

PTM databases

iPTMnetⁱ	P58400

iPTMnetⁱ

P58400

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000179915 Expressed in 176 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_NRXN1
ExpressionAtlasⁱ	P58400 baseline and differential
Genevisibleⁱ	P58400 HS

Interactionⁱ

Subunit structureⁱ

The cytoplasmic C-terminal region binds to CASK. Binds NLGN1, NLGN2 and NLGN3, DAG1 (alpha-dystroglycan) and alpha-latrotoxin. Binding to neuroligins is calcium-dependent, and the binding preference ranks as follow: NLGN1 > NLGN4 >> NLGN3 > NLGN2 (By similarity). Interacts with CBLN2 and more weakly with CBLN4 (By similarity). Interacts with CBLN1; interaction is CBLN1 hexamer form-dependent; CBLN1-binding is calcium-independent; isoform 1b does not interact with CBLN1 (PubMed:27418511).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Nlgn1	Q99K10-1	3	EBI-16513622,EBI-15675933	From a different organism.

With

Entry

#Exp.

IntAct

Notes

Nlgn1

Q99K10-1

3

EBI-16513622,EBI-15675933

From a different organism.

GO - Molecular functionⁱ

calcium-dependent protein binding Source: BHF-UCL
cell adhesion molecule binding Source: BHF-UCL
neuroligin family protein binding Source: ARUK-UCL
signaling receptor binding Source: BHF-UCL
type 1 fibroblast growth factor receptor binding
Source: ARUK-UCL
Inferred from direct assayⁱ
- 22750515

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114779, 15 interactors
Database of interacting proteins More...DIPⁱ	DIP-46402N
IntActⁱ	P58400, 1 interactor

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	91 – 103	Combined sources	13
Beta strandⁱ	112 – 123	Combined sources	12
Beta strandⁱ	126 – 135	Combined sources	10
Beta strandⁱ	142 – 148	Combined sources	7
Beta strandⁱ	151 – 160	Combined sources	10
Beta strandⁱ	163 – 166	Combined sources	4
Beta strandⁱ	174 – 176	Combined sources	3
Beta strandⁱ	178 – 185	Combined sources	8
Beta strandⁱ	188 – 196	Combined sources	9
Beta strandⁱ	199 – 201	Combined sources	3
Beta strandⁱ	244 – 250	Combined sources	7
Turnⁱ	252 – 255	Combined sources	4
Beta strandⁱ	260 – 267	Combined sources	8
Helixⁱ	272 – 276	Combined sources	5
Turnⁱ	277 – 279	Combined sources	3
Beta strandⁱ	283 – 290	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P58400
SMRⁱ	P58400
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P58400

EvolutionaryTraceⁱ

P58400

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	91 – 289	Laminin G-likePROSITE-ProRule annotationAdd BLAST		199

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	205 – 234	Essential for interaction with CBLN1; modulates interaction affinity with NLGN1, NLGN2 and NLGN3; prevents interaction with DAG1/alpha-dystroglycan; modulates interaction with alpha-latrotoxinBy similarity1 PublicationAdd BLAST		30

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	9 – 29	Gly-richPROSITE-ProRule annotationAdd BLAST	21
Compositional biasⁱ	300 – 343	Thr-richPROSITE-ProRule annotationAdd BLAST	44
Compositional biasⁱ	404 – 407	Poly-Ala	4

Sequence similaritiesⁱ

Belongs to the neurexin family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118991
HOGENOMⁱ	HOG000230482
HOVERGENⁱ	HBG052670
KEGG Orthology (KO) More...KOⁱ	K07377

Family and domain databases

InterProⁱ	View protein in InterPro IPR013320 ConA-like_dom_sf IPR001791 Laminin_G IPR037440 Neurexin IPR003585 Neurexin-like IPR027789 Syndecan/Neurexin_dom
PANTHERⁱ	PTHR44287 PTHR44287, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02210 Laminin_G_2, 1 hit PF01034 Syndecan, 1 hit
SMARTⁱ	View protein in SMART SM00294 4.1m, 1 hit SM00282 LamG, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50025 LAM_G_DOMAIN, 1 hit

Sequences (6)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsⁱ produced by alternative promoter usage and alternative splicing. Align Add to basket

Note: A number of isoforms are produced by alternative promoter usage including the alpha-type and beta-type isoforms which differ in their N-terminus. Additional isoforms may be produced by alternative splicing.

Isoform 1b (identifier: P58400-2) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQRMLRCGA ELGSPGGGGG GGGGGGAGGR LALLWIVPLT LSGLLGVAWG 
        60         70         80         90        100
ASSLGAHHIH HFHGSSKHHS VPIAIYRSPA SLRGGHAGTT YIFSKGGGQI 
       110        120        130        140        150
TYKWPPNDRP STRADRLAIG FSTVQKEAVL VRVDSSSGLG DYLELHIHQG 
       160        170        180        190        200
KIGVKFNVGT DDIAIEESNA IINDGKYHVV RFTRSGGNAT LQVDSWPVIE 
       210        220        230        240        250
RYPAGNNDNE RLAIARQRIP YRLGRVVDEW LLDKGRQLTI FNSQATIIIG 
       260        270        280        290        300
GKEQGQPFQG QLSGLYYNGL KVLNMAAEND ANIAIVGNVR LVGEVPSSMT 
       310        320        330        340        350
TESTATAMQS EMSTSIMETT TTLATSTARR GKPPTKEPIS QTTDDILVAS 
       360        370        380        390        400
AECPSDDEDI DPCEPSSGGL ANPTRAGGRE PYPGSAEVIR ESSSTTGMVV 
       410        420        430        440        450
GIVAAAALCI LILLYAMYKY RNRDEGSYHV DESRNYISNS AQSNGAVVKE 
       460        470 
KQPSSAKSSN KNKKNKDKEY YV

Length:472

Mass (Da):50,424

Last modified:August 30, 2017 - v3

Checksum:ⁱC86516C0EB7A2D01

GO

Isoform 3b (identifier: P58400-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
205-234: Missing.

« Hide

        10         20         30         40         50
MYQRMLRCGA ELGSPGGGGG GGGGGGAGGR LALLWIVPLT LSGLLGVAWG 
        60         70         80         90        100
ASSLGAHHIH HFHGSSKHHS VPIAIYRSPA SLRGGHAGTT YIFSKGGGQI 
       110        120        130        140        150
TYKWPPNDRP STRADRLAIG FSTVQKEAVL VRVDSSSGLG DYLELHIHQG 
       160        170        180        190        200
KIGVKFNVGT DDIAIEESNA IINDGKYHVV RFTRSGGNAT LQVDSWPVIE 
       210        220        230        240        250
RYPAGRQLTI FNSQATIIIG GKEQGQPFQG QLSGLYYNGL KVLNMAAEND 
       260        270        280        290        300
ANIAIVGNVR LVGEVPSSMT TESTATAMQS EMSTSIMETT TTLATSTARR 
       310        320        330        340        350
GKPPTKEPIS QTTDDILVAS AECPSDDEDI DPCEPSSGGL ANPTRAGGRE 
       360        370        380        390        400
PYPGSAEVIR ESSSTTGMVV GIVAAAALCI LILLYAMYKY RNRDEGSYHV 
       410        420        430        440 
DESRNYISNS AQSNGAVVKE KQPSSAKSSN KNKKNKDKEY YV

Show »

Length:442

Mass (Da):46,861

Checksum:ⁱ49A8DA1E2DEDA804

GO

Isoform 1a (identifier: Q9ULB1-1) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:1,477

Mass (Da):161,883

GO

Isoform 2a (identifier: Q9ULB1-2) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative splicing. No experimental confirmation available.

Length:1,496

Mass (Da):164,428

GO

Isoform 3a (identifier: Q9ULB1-3) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative splicing.

Length:1,547

Mass (Da):169,913

GO

Isoform 4 (identifier: Q9ULB1-4) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative promoter usage and alternative splicing.Curated

Length:139

Mass (Da):15,277

GO

Sequence cautionⁱ

The sequence AF064842 differs from that shown. Reason: Frameshift at position 54.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	20	G → R in AF064842 (PubMed:9921901).Curated	1
Sequence conflictⁱ	46	G → R in AF064842 (PubMed:9921901).Curated	1
Sequence conflictⁱ	158	V → I in AF064842 (PubMed:9921901).Curated	1
Sequence conflictⁱ	288	N → D in AF064842 (PubMed:9921901).Curated	1
Sequence conflictⁱ	344	D → G in AF064842 (PubMed:9921901).Curated	1
Sequence conflictⁱ	415	Y → C in AF064842 (PubMed:9921901).Curated	1
Sequence conflictⁱ	418 – 420	YKY → NKC in AF064842 (PubMed:9921901).Curated	3

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_059057	205 – 234	Missing in isoform 3b. Add BLAST		30

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF064842 mRNA No translation available. AC007462 Genomic DNA No translation available. AC007560 Genomic DNA No translation available. AC007680 Genomic DNA No translation available. AC007682 Genomic DNA No translation available. AC009234 Genomic DNA No translation available. AC010721 Genomic DNA No translation available. AC068715 Genomic DNA No translation available. AC068725 Genomic DNA No translation available. AC069550 Genomic DNA No translation available. AC078994 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1845.1 [P58400-1] CCDS82446.1 [P58400-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001317021.1, NM_001330092.1 [P58400-2] NP_620072.1, NM_138735.4 [P58400-1]
UniGeneⁱ	Hs.637685

Genome annotation databases

Ensemblⁱ	ENST00000342183; ENSP00000341184; ENSG00000179915 [P58400-1] ENST00000401710; ENSP00000385580; ENSG00000179915 [P58400-2]
GeneIDⁱ	9378
KEGGⁱ	hsa:9378
UCSC genome browser More...UCSCⁱ	uc010fbp.4 human [P58400-2]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage, Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P58400	Neurexin-1-beta		MOUSE		468	UniRef90_P0DI97
Neurexin-1-beta	)	RAT		468
Neurexin-1-beta	)	BOVIN		467
Neurexin-1-beta		CHICK		466
neurexin-1-beta isoform X5		DIPOR		474
+119
P58400-1	Isoform 3b of Neurexin-1-beta		RAT		438	UniRef90_Q63373-3
neurexin-1 isoform X25		DELLE		443
neurexin-1-beta isoform X2		TURTR		443
neurexin-1 isoform X20		Yangtze finless porpoise		443
neurexin-1 isoform X20		PHYCD		442
+98
Q9ULB1-2	Isoform 2a of Neurexin-1		MOUSE		1507	UniRef90_Q9CS84-2
Neurexin-1 (Fragment)		CHICK		1363
LOW QUALITY PROTEIN: neurexin-1		Enhydra lutris kenyoni		1516
neurexin-1-beta isoform X3		BALAS		1510
neurexin-1 isoform X3		DELLE		1510
+537
Q9ULB1-3	NRXN1 isoform 13		PONAB		1547	UniRef90_Q9ULB1-3
Uncharacterized protein		NOMLE		1547
Neurexin 1		GORGO		1547
Uncharacterized protein		PANPA		1445
Neurexin 1		MELGA		1363
+83
Q9ULB1-4	Isoform 6 of Neurexin-1		MOUSE		139	UniRef90_Q9CS84-6
Neurexin-1-beta		HUMAN		143
Uncharacterized protein		PROCO		143
NRXN1 isoform 65		PONAB		143
NRXN1 isoform 3		PANTR		143
+49

Protein	Similar proteins		Species	Score	Length	Source
P58400	Neurexin-1-beta		MOUSE		468	UniRef50_P0DI97
Neurexin-1-beta	)	RAT		468
Neurexin-1-beta	)	BOVIN		467
Neurexin-1-beta		CHICK		466
Neurexin-1b-beta		DANRE		448
+364
Q9ULB1-2	Neurexin-1	)	MOUSE		1514	UniRef50_Q9CS84
Neurexin-1	)	RAT		1530
Neurexin-1	)	BOVIN		1530
Neurexin-1		HUMAN		1477
Neurexin-1a		DANRE		1491
+4348
Q9ULB1-3	Neurexin 1		GORGO		1547	UniRef50_Q9ULB1-3
Uncharacterized protein		NOMLE		1547
NRXN1 isoform 13		PONAB		1547
Uncharacterized protein		PANPA		1445
Neurexin 1		MELGA		1363
+122
Q9ULB1-4	Isoform 6 of Neurexin-1		MOUSE		139	UniRef50_Q9CS84-6
Uncharacterized protein		MANLE		143
Uncharacterized protein		PROCO		143
Neurexin-1-beta		HUMAN		143
NRXN1 isoform 65		PONAB		143
+88

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF064842 mRNA No translation available. AC007462 Genomic DNA No translation available. AC007560 Genomic DNA No translation available. AC007680 Genomic DNA No translation available. AC007682 Genomic DNA No translation available. AC009234 Genomic DNA No translation available. AC010721 Genomic DNA No translation available. AC068715 Genomic DNA No translation available. AC068725 Genomic DNA No translation available. AC069550 Genomic DNA No translation available. AC078994 Genomic DNA No translation available.
CCDSⁱ	CCDS1845.1 [P58400-1] CCDS82446.1 [P58400-2]
RefSeqⁱ	NP_001317021.1, NM_001330092.1 [P58400-2] NP_620072.1, NM_138735.4 [P58400-1]
UniGeneⁱ	Hs.637685

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3B3Q	X-ray	2.40	E/F	85-296	[»]
ProteinModelPortalⁱ	P58400
SMRⁱ	P58400
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114779, 15 interactors
DIPⁱ	DIP-46402N
IntActⁱ	P58400, 1 interactor

PTM databases

iPTMnetⁱ	P58400

iPTMnetⁱ

P58400

Polymorphism and mutation databases

BioMutaⁱ	FSHR
DMDMⁱ	322510054

Proteomic databases

PeptideAtlasⁱ	P58400
PRIDEⁱ	P58400
ProteomicsDBⁱ	57071

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000342183; ENSP00000341184; ENSG00000179915 [P58400-1] ENST00000401710; ENSP00000385580; ENSG00000179915 [P58400-2]
GeneIDⁱ	9378
KEGGⁱ	hsa:9378
UCSCⁱ	uc010fbp.4 human [P58400-2]

Organism-specific databases

CTDⁱ	9378
DisGeNETⁱ	9378
EuPathDBⁱ	HostDB:ENSG00000179915.21
GeneCardsⁱ	NRXN1
HGNCⁱ	HGNC:8008 NRXN1
MalaCardsⁱ	NRXN1
MIMⁱ	600565 gene
neXtProtⁱ	NX_P58400
OpenTargetsⁱ	ENSG00000179915
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00760000118991
HOGENOMⁱ	HOG000230482
HOVERGENⁱ	HBG052670
KOⁱ	K07377

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6794361 Neurexins and neuroligins
SIGNORⁱ	P58400

Miscellaneous databases

ChiTaRSⁱ	NRXN1 human
EvolutionaryTraceⁱ	P58400
GeneWikiⁱ	NRXN1
GenomeRNAiⁱ	9378
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179915 Expressed in 176 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_NRXN1
ExpressionAtlasⁱ	P58400 baseline and differential
Genevisibleⁱ	P58400 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR013320 ConA-like_dom_sf IPR001791 Laminin_G IPR037440 Neurexin IPR003585 Neurexin-like IPR027789 Syndecan/Neurexin_dom
PANTHERⁱ	PTHR44287 PTHR44287, 2 hits
Pfamⁱ	View protein in Pfam PF02210 Laminin_G_2, 1 hit PF01034 Syndecan, 1 hit
SMARTⁱ	View protein in SMART SM00294 4.1m, 1 hit SM00282 LamG, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50025 LAM_G_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NRX1B_HUMAN
Accessionⁱ	P58400Primary (citable) accession number: P58400 Secondary accession number(s): E7ETA5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	August 30, 2017
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P58400 (NRX1B_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Neurexin-1-beta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Endoplasmic reticulum

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ