UniProtKB - P58397 (ATS12_HUMAN)
Protein
A disintegrin and metalloproteinase with thrombospondin motifs 12
Gene
ADAMTS12
Organism
Homo sapiens (Human)
Status
Functioni
Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.3 Publications
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Activity regulationi
Inhibited by alpha-2 macroglobulin.1 Publication
pH dependencei
Optimum pH is between 7.5 and 9.5 with COMP for substrate.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 208 | Zinc; in inhibited formBy similarity | 1 | |
Metal bindingi | 392 | Zinc; catalyticBy similarity | 1 | |
Active sitei | 393 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 396 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 402 | Zinc; catalyticBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- metalloendopeptidase activity Source: BHF-UCL
GO - Biological processi
- cell-matrix adhesion Source: BHF-UCL
- cell migration Source: BHF-UCL
- cellular response to BMP stimulus Source: BHF-UCL
- cellular response to interleukin-1 Source: BHF-UCL
- cellular response to tumor necrosis factor Source: BHF-UCL
- extracellular matrix organization Source: GO_Central
- negative regulation of cellular response to hepatocyte growth factor stimulus Source: BHF-UCL
- negative regulation of cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
- negative regulation of chondrocyte differentiation Source: BHF-UCL
- negative regulation of hepatocyte growth factor receptor signaling pathway Source: BHF-UCL
- proteoglycan catabolic process Source: BHF-UCL
- proteolysis involved in cellular protein catabolic process Source: BHF-UCL
- regulation of endothelial tube morphogenesis Source: BHF-UCL
- regulation of inflammatory response Source: BHF-UCL
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P58397 |
Reactomei | R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS) R-HSA-5173214, O-glycosylation of TSR domain-containing proteins |
Protein family/group databases
MEROPSi | M12.237 |
Names & Taxonomyi
Protein namesi | Recommended name: A disintegrin and metalloproteinase with thrombospondin motifs 12 (EC:3.4.24.-)Short name: ADAM-TS 12 Short name: ADAM-TS12 Short name: ADAMTS-12 |
Gene namesi | Name:ADAMTS12 ORF Names:UNQ1918/PRO4389 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14605, ADAMTS12 |
MIMi | 606184, gene |
neXtProti | NX_P58397 |
VEuPathDBi | HostDB:ENSG00000151388.10 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- extracellular matrix Source: GO_Central
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 81792 |
OpenTargetsi | ENSG00000151388 |
PharmGKBi | PA24538 |
Miscellaneous databases
Pharosi | P58397, Tbio |
Genetic variation databases
BioMutai | ADAMTS12 |
DMDMi | 259016182 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
PropeptideiPRO_0000029186 | 26 – 240 | By similarityAdd BLAST | 215 | |
ChainiPRO_0000029187 | 241 – 1594 | A disintegrin and metalloproteinase with thrombospondin motifs 12Add BLAST | 1354 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 105 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 125 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 215 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 322 ↔ 376 | By similarity | ||
Disulfide bondi | 351 ↔ 358 | By similarity | ||
Disulfide bondi | 370 ↔ 451 | By similarity | ||
Disulfide bondi | 409 ↔ 435 | By similarity | ||
Disulfide bondi | 478 ↔ 501 | By similarity | ||
Glycosylationi | 485 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 489 ↔ 507 | By similarity | ||
Disulfide bondi | 496 ↔ 526 | By similarity | ||
Disulfide bondi | 520 ↔ 531 | By similarity | ||
Disulfide bondi | 554 ↔ 591 | By similarity | ||
Disulfide bondi | 558 ↔ 596 | By similarity | ||
Disulfide bondi | 569 ↔ 581 | By similarity | ||
Glycosylationi | 685 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 790 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 952 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1105 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1276 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1301 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1321 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1372 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1379 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1504 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
The precursor is cleaved by a furin endopeptidase.
Subjected to an intracellular maturation process yielding a 120 kDa N-terminal fragment containing the metalloproteinase, disintegrin, one TSP type-1 and the Cys-rich domains and a 83 kDa C-terminal fragment containing the spacer 2 and four TSP type-1 domains.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, ZymogenProteomic databases
CPTACi | CPTAC-2207 |
MassIVEi | P58397 |
PaxDbi | P58397 |
PeptideAtlasi | P58397 |
PRIDEi | P58397 |
ProteomicsDBi | 57068 [P58397-1] 57069 [P58397-2] 57070 [P58397-3] |
PTM databases
GlyConnecti | 996, 5 N-Linked glycans (3 sites) |
GlyGeni | P58397, 15 sites, 1 O-linked glycan (1 site) |
iPTMneti | P58397 |
PhosphoSitePlusi | P58397 |
Expressioni
Tissue specificityi
Expressed in skeletal muscle and fat. Detected at significant levels in fetal lung. Widely expressed in gastric carcinomas and in cancer cells of diverse origin.2 Publications
Inductioni
By IFN-alpha and by IL1B/interleukin-1 beta. Up-regulated in articular cartilage and synovium from arthritis patients. Up-regulared in chondrocytes.2 Publications
Gene expression databases
Bgeei | ENSG00000151388, Expressed in adrenal tissue and 128 other tissues |
ExpressionAtlasi | P58397, baseline and differential |
Genevisiblei | P58397, HS |
Organism-specific databases
HPAi | ENSG00000151388, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with COMP.
1 PublicationBinary interactionsi
Hide detailsP58397
Isoform 3 [P58397-3]
With | #Exp. | IntAct |
---|---|---|
COIL [P38432] | 3 | EBI-12048761,EBI-945751 |
IHO1 [Q8IYA8] | 3 | EBI-12048761,EBI-8638439 |
TP53BP2 [Q05BL1] | 3 | EBI-12048761,EBI-11952721 |
TRIM14 [Q14142] | 3 | EBI-12048761,EBI-2820256 |
Protein-protein interaction databases
BioGRIDi | 123584, 15 interactors |
IntActi | P58397, 18 interactors |
STRINGi | 9606.ENSP00000422554 |
Miscellaneous databases
RNActi | P58397, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 246 – 456 | Peptidase M12BPROSITE-ProRule annotationAdd BLAST | 211 | |
Domaini | 465 – 544 | DisintegrinAdd BLAST | 80 | |
Domaini | 542 – 597 | TSP type-1 1PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 823 – 883 | TSP type-1 2PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 887 – 943 | TSP type-1 3PROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 944 – 997 | TSP type-1 4PROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 1313 – 1366 | TSP type-1 5PROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 1368 – 1422 | TSP type-1 6PROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 1423 – 1471 | TSP type-1 7PROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 1472 – 1532 | TSP type-1 8PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 1535 – 1575 | PLACPROSITE-ProRule annotationAdd BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 701 – 827 | Spacer 1Add BLAST | 127 | |
Regioni | 997 – 1316 | Spacer 2Add BLAST | 320 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 208 – 213 | Cysteine switchBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 302 – 305 | Poly-Glu | 4 | |
Compositional biasi | 597 – 700 | Cys-richAdd BLAST | 104 |
Domaini
The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity
The C-terminal four TSP1-like repeats are necessary and sufficient for binding COMP.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG3538, Eukaryota |
GeneTreei | ENSGT00940000155855 |
HOGENOMi | CLU_000660_2_1_1 |
InParanoidi | P58397 |
OMAi | NTANPCE |
OrthoDBi | 1229120at2759 |
PhylomeDBi | P58397 |
TreeFami | TF313537 |
Family and domain databases
Gene3Di | 2.20.100.10, 8 hits 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR041645, ADAM_CR_2 IPR010294, ADAM_spacer1 IPR013273, ADAMTS/ADAMTS-like IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR010909, PLAC IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF17771, ADAM_CR_2, 1 hit PF05986, ADAM_spacer1, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit PF00090, TSP_1, 1 hit |
PRINTSi | PR01857, ADAMTSFAMILY |
SMARTi | View protein in SMART SM00209, TSP1, 8 hits |
SUPFAMi | SSF82895, SSF82895, 8 hits |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50900, PLAC, 1 hit PS50092, TSP1, 6 hits PS00142, ZINC_PROTEASE, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P58397-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPCAQRSWLA NLSVVAQLLN FGALCYGRQP QPGPVRFPDR RQEHFIKGLP
60 70 80 90 100
EYHVVGPVRV DASGHFLSYG LHYPITSSRR KRDLDGSEDW VYYRISHEEK
110 120 130 140 150
DLFFNLTVNQ GFLSNSYIME KRYGNLSHVK MMASSAPLCH LSGTVLQQGT
160 170 180 190 200
RVGTAALSAC HGLTGFFQLP HGDFFIEPVK KHPLVEGGYH PHIVYRRQKV
210 220 230 240 250
PETKEPTCGL KDSVNISQKQ ELWREKWERH NLPSRSLSRR SISKERWVET
260 270 280 290 300
LVVADTKMIE YHGSENVESY ILTIMNMVTG LFHNPSIGNA IHIVVVRLIL
310 320 330 340 350
LEEEEQGLKI VHHAEKTLSS FCKWQKSINP KSDLNPVHHD VAVLLTRKDI
360 370 380 390 400
CAGFNRPCET LGLSHLSGMC QPHRSCNINE DSGLPLAFTI AHELGHSFGI
410 420 430 440 450
QHDGKENDCE PVGRHPYIMS RQLQYDPTPL TWSKCSEEYI TRFLDRGWGF
460 470 480 490 500
CLDDIPKKKG LKSKVIAPGV IYDVHHQCQL QYGPNATFCQ EVENVCQTLW
510 520 530 540 550
CSVKGFCRSK LDAAADGTQC GEKKWCMAGK CITVGKKPES IPGGWGRWSP
560 570 580 590 600
WSHCSRTCGA GVQSAERLCN NPEPKFGGKY CTGERKRYRL CNVHPCRSEA
610 620 630 640 650
PTFRQMQCSE FDTVPYKNEL YHWFPIFNPA HPCELYCRPI DGQFSEKMLD
660 670 680 690 700
AVIDGTPCFE GGNSRNVCIN GICKMVGCDY EIDSNATEDR CGVCLGDGSS
710 720 730 740 750
CQTVRKMFKQ KEGSGYVDIG LIPKGARDIR VMEIEGAGNF LAIRSEDPEK
760 770 780 790 800
YYLNGGFIIQ WNGNYKLAGT VFQYDRKGDL EKLMATGPTN ESVWIQLLFQ
810 820 830 840 850
VTNPGIKYEY TIQKDGLDND VEQQMYFWQY GHWTECSVTC GTGIRRQTAH
860 870 880 890 900
CIKKGRGMVK ATFCDPETQP NGRQKKCHEK ACPPRWWAGE WEACSATCGP
910 920 930 940 950
HGEKKRTVLC IQTMVSDEQA LPPTDCQHLL KPKTLLSCNR DILCPSDWTV
960 970 980 990 1000
GNWSECSVSC GGGVRIRSVT CAKNHDEPCD VTRKPNSRAL CGLQQCPSSR
1010 1020 1030 1040 1050
RVLKPNKGTI SNGKNPPTLK PVPPPTSRPR MLTTPTGPES MSTSTPAISS
1060 1070 1080 1090 1100
PSPTTASKEG DLGGKQWQDS STQPELSSRY LISTGSTSQP ILTSQSLSIQ
1110 1120 1130 1140 1150
PSEENVSSSD TGPTSEGGLV ATTTSGSGLS SSRNPITWPV TPFYNTLTKG
1160 1170 1180 1190 1200
PEMEIHSGSG EEREQPEDKD ESNPVIWTKI RVPGNDAPVE STEMPLAPPL
1210 1220 1230 1240 1250
TPDLSRESWW PPFSTVMEGL LPSQRPTTSE TGTPRVEGMV TEKPANTLLP
1260 1270 1280 1290 1300
LGGDHQPEPS GKTANRNHLK LPNNMNQTKS SEPVLTEEDA TSLITEGFLL
1310 1320 1330 1340 1350
NASNYKQLTN GHGSAHWIVG NWSECSTTCG LGAYWRRVEC STQMDSDCAA
1360 1370 1380 1390 1400
IQRPDPAKRC HLRPCAGWKV GNWSKCSRNC SGGFKIREIQ CVDSRDHRNL
1410 1420 1430 1440 1450
RPFHCQFLAG IPPPLSMSCN PEPCEAWQVE PWSQCSRSCG GGVQERGVFC
1460 1470 1480 1490 1500
PGGLCDWTKR PTSTMSCNEH LCCHWATGNW DLCSTSCGGG FQKRTVQCVP
1510 1520 1530 1540 1550
SEGNKTEDQD QCLCDHKPRP PEFKKCNQQA CKKSADLLCT KDKLSASFCQ
1560 1570 1580 1590
TLKAMKKCSV PTVRAECCFS CPQTHITHTQ RQRRQRLLQK SKEL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6REX0 | D6REX0_HUMAN | A disintegrin and metalloproteinase... | ADAMTS12 | 232 | Annotation score: | ||
A0A0G2JRM9 | A0A0G2JRM9_HUMAN | A disintegrin and metalloproteinase... | ADAMTS12 | 163 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 824 | Missing in CAC20419 (PubMed:11279086).Curated | 1 | |
Sequence conflicti | 1336 | R → K in CAC20419 (PubMed:11279086).Curated | 1 | |
Sequence conflicti | 1341 | S → T in CAC20419 (PubMed:11279086).Curated | 1 | |
Sequence conflicti | 1578 | H → R in AAI31734 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057074 | 110 | Q → E. Corresponds to variant dbSNP:rs16891862EnsemblClinVar. | 1 | |
Natural variantiVAR_057075 | 1000 | R → Q. Corresponds to variant dbSNP:rs13362345Ensembl. | 1 | |
Natural variantiVAR_059761 | 1177 | W → R. Corresponds to variant dbSNP:rs3813474Ensembl. | 1 | |
Natural variantiVAR_058972 | 1495 | T → I1 PublicationCorresponds to variant dbSNP:rs25754Ensembl. | 1 | |
Natural variantiVAR_059762 | 1591 | S → P. Corresponds to variant dbSNP:rs16891281Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013141 | 212 – 229 | DSVNI…EKWER → GIVTHMSSWVEESVLFFW in isoform 2. 2 PublicationsAdd BLAST | 18 | |
Alternative sequenceiVSP_013142 | 230 – 1594 | Missing in isoform 2. 2 PublicationsAdd BLAST | 1365 | |
Alternative sequenceiVSP_038151 | 630 – 714 | Missing in isoform 3. 1 PublicationAdd BLAST | 85 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ250725 mRNA Translation: CAC20419.1 AY358745 mRNA Translation: AAQ89105.1 AC008880 Genomic DNA No translation available. AC034232 Genomic DNA No translation available. AC109491 Genomic DNA No translation available. AC139777 Genomic DNA No translation available. BC058841 mRNA Translation: AAH58841.1 BC131733 mRNA Translation: AAI31734.1 BC139900 mRNA Translation: AAI39901.1 |
CCDSi | CCDS34140.1 [P58397-1] CCDS87293.1 [P58397-3] |
RefSeqi | NP_001311440.1, NM_001324511.1 NP_001311441.1, NM_001324512.1 [P58397-3] NP_112217.2, NM_030955.3 [P58397-1] |
Genome annotation databases
Ensembli | ENST00000352040; ENSP00000344847; ENSG00000151388 [P58397-3] ENST00000504830; ENSP00000422554; ENSG00000151388 [P58397-1] |
GeneIDi | 81792 |
KEGGi | hsa:81792 |
UCSCi | uc003jia.3, human [P58397-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ250725 mRNA Translation: CAC20419.1 AY358745 mRNA Translation: AAQ89105.1 AC008880 Genomic DNA No translation available. AC034232 Genomic DNA No translation available. AC109491 Genomic DNA No translation available. AC139777 Genomic DNA No translation available. BC058841 mRNA Translation: AAH58841.1 BC131733 mRNA Translation: AAI31734.1 BC139900 mRNA Translation: AAI39901.1 |
CCDSi | CCDS34140.1 [P58397-1] CCDS87293.1 [P58397-3] |
RefSeqi | NP_001311440.1, NM_001324511.1 NP_001311441.1, NM_001324512.1 [P58397-3] NP_112217.2, NM_030955.3 [P58397-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123584, 15 interactors |
IntActi | P58397, 18 interactors |
STRINGi | 9606.ENSP00000422554 |
Protein family/group databases
MEROPSi | M12.237 |
PTM databases
GlyConnecti | 996, 5 N-Linked glycans (3 sites) |
GlyGeni | P58397, 15 sites, 1 O-linked glycan (1 site) |
iPTMneti | P58397 |
PhosphoSitePlusi | P58397 |
Genetic variation databases
BioMutai | ADAMTS12 |
DMDMi | 259016182 |
Proteomic databases
CPTACi | CPTAC-2207 |
MassIVEi | P58397 |
PaxDbi | P58397 |
PeptideAtlasi | P58397 |
PRIDEi | P58397 |
ProteomicsDBi | 57068 [P58397-1] 57069 [P58397-2] 57070 [P58397-3] |
Protocols and materials databases
Antibodypediai | 22743, 130 antibodies |
Genome annotation databases
Ensembli | ENST00000352040; ENSP00000344847; ENSG00000151388 [P58397-3] ENST00000504830; ENSP00000422554; ENSG00000151388 [P58397-1] |
GeneIDi | 81792 |
KEGGi | hsa:81792 |
UCSCi | uc003jia.3, human [P58397-1] |
Organism-specific databases
CTDi | 81792 |
DisGeNETi | 81792 |
GeneCardsi | ADAMTS12 |
HGNCi | HGNC:14605, ADAMTS12 |
HPAi | ENSG00000151388, Low tissue specificity |
MIMi | 606184, gene |
neXtProti | NX_P58397 |
OpenTargetsi | ENSG00000151388 |
PharmGKBi | PA24538 |
VEuPathDBi | HostDB:ENSG00000151388.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3538, Eukaryota |
GeneTreei | ENSGT00940000155855 |
HOGENOMi | CLU_000660_2_1_1 |
InParanoidi | P58397 |
OMAi | NTANPCE |
OrthoDBi | 1229120at2759 |
PhylomeDBi | P58397 |
TreeFami | TF313537 |
Enzyme and pathway databases
PathwayCommonsi | P58397 |
Reactomei | R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS) R-HSA-5173214, O-glycosylation of TSR domain-containing proteins |
Miscellaneous databases
BioGRID-ORCSi | 81792, 6 hits in 874 CRISPR screens |
ChiTaRSi | ADAMTS12, human |
GeneWikii | ADAMTS12 |
GenomeRNAii | 81792 |
Pharosi | P58397, Tbio |
PROi | PR:P58397 |
RNActi | P58397, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151388, Expressed in adrenal tissue and 128 other tissues |
ExpressionAtlasi | P58397, baseline and differential |
Genevisiblei | P58397, HS |
Family and domain databases
Gene3Di | 2.20.100.10, 8 hits 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR041645, ADAM_CR_2 IPR010294, ADAM_spacer1 IPR013273, ADAMTS/ADAMTS-like IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR010909, PLAC IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF17771, ADAM_CR_2, 1 hit PF05986, ADAM_spacer1, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit PF00090, TSP_1, 1 hit |
PRINTSi | PR01857, ADAMTSFAMILY |
SMARTi | View protein in SMART SM00209, TSP1, 8 hits |
SUPFAMi | SSF82895, SSF82895, 8 hits |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50900, PLAC, 1 hit PS50092, TSP1, 6 hits PS00142, ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATS12_HUMAN | |
Accessioni | P58397Primary (citable) accession number: P58397 Secondary accession number(s): A2RRN9, A5D6V6, Q6UWL3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | September 22, 2009 | |
Last modified: | February 10, 2021 | |
This is version 189 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM