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Protein

Cadherin-23

Gene

Cdh23

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • protein N-terminus binding Source: RGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Hearing
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin-23
Alternative name(s):
Otocadherin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cdh23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
619760 Cdh23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 3062ExtracellularSequence analysisAdd BLAST3039
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3063 – 3083HelicalSequence analysisAdd BLAST21
Topological domaini3084 – 3317CytoplasmicSequence analysisAdd BLAST234

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000382624 – 3317Cadherin-23Add BLAST3294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi464N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi600N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi692N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi763N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi808N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi825N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi939N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi999N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1016N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1313N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1532N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1649N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1665N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1816N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1855N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1887N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1900N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2012N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2048N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2355N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2576N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2614N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2747N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2806N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2875N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2894N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2939N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2979N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P58365

PRoteomics IDEntifications database

More...
PRIDEi
P58365

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P58365

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P58365

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

antiparallel heterodimer with PCDH15 (By similarity). Interacts with USH1C and USH1G (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000048338

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P58365

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P58365

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 132Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini133 – 236Cadherin 2PROSITE-ProRule annotationAdd BLAST104
Domaini237 – 348Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini349 – 458Cadherin 4PROSITE-ProRule annotationAdd BLAST110
Domaini459 – 559Cadherin 5PROSITE-ProRule annotationAdd BLAST101
Domaini560 – 669Cadherin 6PROSITE-ProRule annotationAdd BLAST110
Domaini670 – 782Cadherin 7PROSITE-ProRule annotationAdd BLAST113
Domaini777 – 888Cadherin 8PROSITE-ProRule annotationAdd BLAST112
Domaini889 – 993Cadherin 9PROSITE-ProRule annotationAdd BLAST105
Domaini994 – 1100Cadherin 10PROSITE-ProRule annotationAdd BLAST107
Domaini1101 – 1206Cadherin 11PROSITE-ProRule annotationAdd BLAST106
Domaini1208 – 1311Cadherin 12PROSITE-ProRule annotationAdd BLAST104
Domaini1312 – 1416Cadherin 13PROSITE-ProRule annotationAdd BLAST105
Domaini1418 – 1525Cadherin 14PROSITE-ProRule annotationAdd BLAST108
Domaini1527 – 1632Cadherin 15PROSITE-ProRule annotationAdd BLAST106
Domaini1633 – 1742Cadherin 16PROSITE-ProRule annotationAdd BLAST110
Domaini1743 – 1849Cadherin 17PROSITE-ProRule annotationAdd BLAST107
Domaini1850 – 1957Cadherin 18PROSITE-ProRule annotationAdd BLAST108
Domaini1958 – 2067Cadherin 19PROSITE-ProRule annotationAdd BLAST110
Domaini2068 – 2172Cadherin 20PROSITE-ProRule annotationAdd BLAST105
Domaini2173 – 2291Cadherin 21PROSITE-ProRule annotationAdd BLAST119
Domaini2295 – 2400Cadherin 22PROSITE-ProRule annotationAdd BLAST106
Domaini2401 – 2507Cadherin 23PROSITE-ProRule annotationAdd BLAST107
Domaini2508 – 2609Cadherin 24PROSITE-ProRule annotationAdd BLAST102
Domaini2612 – 2720Cadherin 25PROSITE-ProRule annotationAdd BLAST109
Domaini2727 – 2844Cadherin 26PROSITE-ProRule annotationAdd BLAST118
Domaini2845 – 2973Cadherin 27PROSITE-ProRule annotationAdd BLAST129

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with PCDH15.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000139588

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050768

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P58365

KEGG Orthology (KO)

More...
KOi
K06813

Database of Orthologous Groups

More...
OrthoDBi
17702at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P58365

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR033030 CDH23

The PANTHER Classification System

More...
PANTHERi
PTHR43956:SF3 PTHR43956:SF3, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 25 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 26 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 27 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 17 hits
PS50268 CADHERIN_2, 27 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P58365-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRHPPVTWCA MLWLLMLVSG SWGQVNRLPF FTNHFFDTYL LISEDTPVGS
60 70 80 90 100
SVTQLLARDM DNDPLVFGVS GEEASRFFAV EPDTGVVWLR QPLDRETKSE
110 120 130 140 150
FTVEFSVSDH QGVITRKVNI QVGDVNDNAP TFHNQPYSVR IPENTPVGTP
160 170 180 190 200
IFIVNATDPD LGAGGSVLYS FQPPSQFFAI DSARGIVTVI RELDYEVTQA
210 220 230 240 250
YQLTVNATDQ DKTRPLSTLA NLAIIITDVQ DMDPIFINLP YSTNIYEHSP
260 270 280 290 300
PGTTVRVITA VDQDKGRPRG IGYTIVSGNT NSIFALDYIS GALTLNGLLD
310 320 330 340 350
RENPLYSHGF ILTVKGTELN DDRSPSDATV TTTFNILVID INDNAPEFNS
360 370 380 390 400
SEYSVAITEL AQVGFALPLF IQVVDKDEGL NSMFEVYLVG NNSHHFIISP
410 420 430 440 450
TSVQGKADIR IRVAIPLDYE TVDRYDFDLF ANESVPDHVG YAKVKITLIN
460 470 480 490 500
ENDNRPIFSQ PLYNVSLYEN ITVGTSVLTV LATDNDVGTF GEVNYFFSDD
510 520 530 540 550
PDRFSLDKDT GLIMLIARLD YELIQRFTLT VIARDGGGEE TTGRVRINVL
560 570 580 590 600
DVNDNVPTFQ KDAYVGALRE NEPSVTQLVR LRATDEDSPP NNLITYSIVN
610 620 630 640 650
ASAFGSYFDI SVYEGYGVIS VSRPLDYEQI PNGLIYLTVM AKDAGNPPLY
660 670 680 690 700
STVPVTIEVF DENDNPPTFS KPAYFVSVVE NIMAGATVLF LNATDLDRSR
710 720 730 740 750
EYGQESIIYS LEGSSQFRIN ARSGEITTTS LLDRETKAEY ILIVRAVDGG
760 770 780 790 800
VGHNQKTGIA TVNVTLLDIN DNHPTWKDAP YYINLVEMTP PDSDVTTVVA
810 820 830 840 850
VDPDLGKNGT LVYSIQPPNK FYSLNSTTGK IRTTHVMLDR ENPDPVEAEL
860 870 880 890 900
MRKIIVSVTD CGRPPLKATS SATVFVNLLD LNDNDPTFQN LPFVAEVLEG
910 920 930 940 950
TPAGVSVYQV VAIDLDEGLN GLVSYRMQVG MPRMDFVINS TSGVVTTTAE
960 970 980 990 1000
LDRERIAEYQ LRVVASDAGT PTKSSTSTLT IRVLDVNDET PTFFPAVYNV
1010 1020 1030 1040 1050
SVSEDVPREF RVVWLNCTDN DVGLNAELSY FITAGNVDGK FSVGYRDAVV
1060 1070 1080 1090 1100
RTVVGLDRET TAAYTLVLEA IDNVPVGKRR TGTATVFVTV LDVNDNRPIF
1110 1120 1130 1140 1150
LQSSYEASVP EDIPEGHSIV QLKATDADEG EFGRVWYRIL HGNHGNNFRL
1160 1170 1180 1190 1200
HVSSGLLVRG PRPLDRERNS SHVLMAEAYN HDLGPMRSSV RVIVYVEDVN
1210 1220 1230 1240 1250
DEAPVFTQQQ YNRLGLRETA GIGTSVIVVR ATDRDTGDGG LVNYRILSGA
1260 1270 1280 1290 1300
EGKFEIDEST GLIVTVDYLD YETKTSYLMN VSATDGAPPF NQGFCSVYVT
1310 1320 1330 1340 1350
LLNELDEAVQ FSNASYEAVI MENLALGTEI VRVQAYSIDN LNQITYRFDA
1360 1370 1380 1390 1400
YTSAQAKALF KIDAITGVIT VKGLVDREKG DFYTLTVVAD DGGPKVDSTV
1410 1420 1430 1440 1450
KVYVTVLDEN DNSPRFDFTS DSAISVPEDC PVGQRVATVK ARDPDAGSNG
1460 1470 1480 1490 1500
QVVFSLASGN IAGAFEIITS NDSIGEVFVA KPLDREELDH YILKIVASDR
1510 1520 1530 1540 1550
GTPPRKKDHI LQVTILDVND NPPVIESPFG YNVSVNENVG GGTSVVQVRA
1560 1570 1580 1590 1600
TDRDIGINSV LSYYITEGNE DMTFRMDRIS GEIATRPAPP DRERQNFYHL
1610 1620 1630 1640 1650
VVTVEDEGTP TLSATTHVYV TIVDENDNAP VFQQPHYEVV LDEGPDTVNT
1660 1670 1680 1690 1700
SLITVQALDL DEGPNGTVTY AIVAGNIINT FRINRRTGVI TAAKELDYEI
1710 1720 1730 1740 1750
SHGRYTLIVT ATDQCPILSH RLTSTTTVLV NVNDINDNVP TFPRDYEGPF
1760 1770 1780 1790 1800
DVTEGQPGPR VWTFLAHDRD SGPNGQVEYS VVDGDPLGEF VISPVEGVLR
1810 1820 1830 1840 1850
VRKDVELDRE TIAFYNLTIC ARDRGVPPLS STMLVGIRVL DINDNDPVLL
1860 1870 1880 1890 1900
NLPMNITISE NSPVSSFVAH VLASDADSGC NALLTFNITA GNRERAFFIN
1910 1920 1930 1940 1950
ATTGIVTVNR PLDRERIPEY RLTVSVKDNP ENPRIARKDF DLLLVSLADE
1960 1970 1980 1990 2000
NDNHPLFTEG TYQAEVMENS PAGTPLTVLN GPILALDADE DVYAVVTYQL
2010 2020 2030 2040 2050
LGTHSDLFVI DNSTGVVTVR SGVIIDREAF SPPFLELLLL AEDVGQLNGT
2060 2070 2080 2090 2100
AYLFITILDD NDNWPTFSPP AYTVHLLENC PPGFSVLQIT ATDEDSGLNG
2110 2120 2130 2140 2150
ELVYRIEAGA QDRFLIHPVT GVIRVGNATI DREEQESYRL TVVATDRGTV
2160 2170 2180 2190 2200
PLSGTATVTI LIDDINDSRP EFLNPIQTVS VLESTEPGTV IANVTAIDLD
2210 2220 2230 2240 2250
LNPKLEYHIL SIVAKDDTDR LVPDQEDAFA VNINTGSVIV KSPLNRELVA
2260 2270 2280 2290 2300
TYEVTLSVID NASDLPERSV SVPNAKLTVN ILDVNDNTPQ FKPFGITYYT
2310 2320 2330 2340 2350
ERVLEGATPG TTLIAVAAVD PDKGLNGLIT YTLLDLIPPG YVQLEDSSAG
2360 2370 2380 2390 2400
KVIANRTVDY EEVHWLNFTV RASDNGSPPR AAEIPVYLEI VDINDNNPIF
2410 2420 2430 2440 2450
DQLSYQEAVF EDVAVGTVIL RVTATDADSG NFALIEYSLV DGEGKFAINP
2460 2470 2480 2490 2500
NTGDIYVLSS LDREKKDHYI LTALAKDNPG DVASNRRENS VQVVIRVLDV
2510 2520 2530 2540 2550
NDCRPQFSKP QFSTSVYENE PAGTSVITML ATDQDEGSNG QLTYSLEGPG
2560 2570 2580 2590 2600
MEAFSVDMDS GLVTTQRPLQ SYERFNLTVV ATDGGEPPLW GTTMLLVEVI
2610 2620 2630 2640 2650
DVNDNRPVFV RPPNGTILHI KEEIPLRSNV YEVYATDKDE GLNGAVRYSF
2660 2670 2680 2690 2700
LKSTGNRDWE YFTIDPISGL IQTAQRLDRE KQAVYSLILV ASDLGQPVPY
2710 2720 2730 2740 2750
ETMQPLQVAL EDIDDNEPLF VRPPKGSPQY QLLTVPEHSP RGTLVGNVTG
2760 2770 2780 2790 2800
AVDADEGPNA IVYYFIAAGN EDKNFHLQPD GRLLVLRDLD RETEAIFSFI
2810 2820 2830 2840 2850
VKASSNRSWT PPRGPSPALD LLTDLTLQEV RVVLEDINDQ PPRFTKAEYT
2860 2870 2880 2890 2900
AGVATDAKVG SELIQVLALD ADIGNNSLVF YGILAIHYFR ALANDSEDVG
2910 2920 2930 2940 2950
QVFTMGSVDG ILRTFDLFMA YSPGYFVVDI VARDLAGHND TAIIGIYILR
2960 2970 2980 2990 3000
DDQRVKIVIN EIPDRVRGFE EEFIRLLSNI TGAIVNTDDV QFHVDMKGRV
3010 3020 3030 3040 3050
NFAQTELLIH VVNRDTNRIL DVDRVIQMID ENKEQLRNLF RNYNVLDVQP
3060 3070 3080 3090 3100
AISVQLPDDM SALQMAIIVL AILLFLAAML FVLMNWYYRT IHKRKLKAIV
3110 3120 3130 3140 3150
AGSAGNRGFI DIMDMPNTNK YSFDGANPVW LDPFCRNLEL AAQAEHEDDL
3160 3170 3180 3190 3200
PENLSEIADL WNSPTRTHGT FGREPAAVKP EDDRYLRAAI QEYDNIAKLG
3210 3220 3230 3240 3250
QIIREGPIKL IHTDLEEEPG DHSPGQGSLR FRHKPPTELK GPDGIHIVHG
3260 3270 3280 3290 3300
STGTLLATDL NSLPEDDQKG LDRSLETLTA SEATAFERNA RTESAKSTPL
3310
HKLRDVIMES PLEITEL
Length:3,317
Mass (Da):365,455
Last modified:November 16, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEF397A066BF0986
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB053447 mRNA Translation: BAB61904.1

NCBI Reference Sequences

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RefSeqi
NP_446096.1, NM_053644.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Rn.208796

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
114102

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:114102

UCSC genome browser

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UCSCi
RGD:619760 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053447 mRNA Translation: BAB61904.1
RefSeqiNP_446096.1, NM_053644.1
UniGeneiRn.208796

3D structure databases

ProteinModelPortaliP58365
SMRiP58365
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048338

PTM databases

iPTMnetiP58365
PhosphoSitePlusiP58365

Proteomic databases

PaxDbiP58365
PRIDEiP58365

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114102
KEGGirno:114102
UCSCiRGD:619760 rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64072
RGDi619760 Cdh23

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOGENOMiHOG000139588
HOVERGENiHBG050768
InParanoidiP58365
KOiK06813
OrthoDBi17702at2759
PhylomeDBiP58365

Miscellaneous databases

Protein Ontology

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PROi
PR:P58365

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR033030 CDH23
PANTHERiPTHR43956:SF3 PTHR43956:SF3, 2 hits
PfamiView protein in Pfam
PF00028 Cadherin, 25 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 26 hits
SUPFAMiSSF49313 SSF49313, 27 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 17 hits
PS50268 CADHERIN_2, 27 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAD23_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58365
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: January 16, 2019
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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