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Entry version 125 (13 Feb 2019)
Sequence version 1 (16 Nov 2001)
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Protein

Membrane-associated transporter protein

Gene

Slc45a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • sucrose:proton symporter activity Source: MGI

GO - Biological processi

  • developmental pigmentation Source: MGI
  • melanin biosynthetic process Source: UniProtKB-KW
  • response to stimulus Source: UniProtKB-KW
  • sucrose transport Source: MGI
  • visual perception Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processMelanin biosynthesis, Sensory transduction, Vision

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5662702 Melanin biosynthesis

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.2.4.14 the glycoside-pentoside-hexuronide (gph):cation symporter family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-associated transporter protein
Alternative name(s):
Melanoma antigen AIM1
Short name:
Protein AIM-1
Protein underwhite
Solute carrier family 45 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc45a2
Synonyms:Aim1, Matp, uw
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2153040 Slc45a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 45CytoplasmicSequence analysisAdd BLAST45
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei46 – 66Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini67 – 68ExtracellularSequence analysis2
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 105CytoplasmicSequence analysisAdd BLAST16
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 138ExtracellularSequence analysisAdd BLAST12
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 184CytoplasmicSequence analysisAdd BLAST25
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 216ExtracellularSequence analysisAdd BLAST11
Transmembranei217 – 237Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini238 – 318CytoplasmicSequence analysisAdd BLAST81
Transmembranei319 – 339Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini340 – 366ExtracellularSequence analysisAdd BLAST27
Transmembranei367 – 387Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini388 – 398CytoplasmicSequence analysisAdd BLAST11
Transmembranei399 – 419Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini420 – 425ExtracellularSequence analysis6
Transmembranei426 – 446Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini447 – 477CytoplasmicSequence analysisAdd BLAST31
Transmembranei478 – 498Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini499 – 504ExtracellularSequence analysis6
Transmembranei505 – 525Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini526 – 530CytoplasmicSequence analysis5

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Slc45a2 are the cause of the UW-dbr phenotype that results in loss of nearly all pigmentation in the homozygous state.1 Publication

Keywords - Diseasei

Albinism, Disease mutation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001225181 – 530Membrane-associated transporter proteinAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P58355

PRoteomics IDEntifications database

More...
PRIDEi
P58355

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P58355

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P58355

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Melanocytes, eyes, kidney and uterus.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022243 Expressed in 36 organ(s), highest expression level in stria vascularis of cochlear duct

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P58355 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P58355 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000022851

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P58355

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0637 Eukaryota
ENOG410XPTR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153826

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000128553

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018570

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P58355

KEGG Orthology (KO)

More...
KOi
K15378

Identification of Orthologs from Complete Genome Data

More...
OMAi
VSMEPFR

Database of Orthologous Groups

More...
OrthoDBi
1230185at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P58355

TreeFam database of animal gene trees

More...
TreeFami
TF325412

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846 MFS_dom
IPR036259 MFS_trans_sf

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P58355-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGSNGPTDT HTYQSLAEDC PFGSVEQPKR STGRLVMHSM AMFGREFCYA
60 70 80 90 100
VEAAYVTPVL LSVGLPKSLY SMVWLLSPIL GFLLQPVVGS ASDHCRARWG
110 120 130 140 150
RRRPYILTLA IMMLLGMALY LNGDAVVSAL VANPRQKLIW AISITMVGVV
160 170 180 190 200
LFDFSADFID GPIKAYLFDV CSHQDKEKGL HYHALFTGFG GALGYILGAI
210 220 230 240 250
DWVHLDLGRL LGTEFQVMFF FSALVLILCF ITHLCSIPEA PLRDAATDPP
260 270 280 290 300
SQQDPQGSSL SASGMHEYGS IEKVKNGGAD TEQPVQEWKN KKPSGQSQRT
310 320 330 340 350
MSMKSLLRAL VNMPSHYRCL CVSHLIGWTA FLSNMLFFTD FMGQIVYHGD
360 370 380 390 400
PYGAHNSTEF LIYERGVEVG CWGLCINSVF SSVYSYFQKA MVSYIGLKGL
410 420 430 440 450
YFMGYLLFGL GTGFIGLFPN VYSTLVLCSM FGVMSSTLYT VPFNLIAEYH
460 470 480 490 500
REEEKEKGQE APGGPDNQGR GKGVDCAALT CMVQLAQILV GGGLGFLVNM
510 520 530
AGSVVVVVIT ASAVSLIGCC FVALFVRYVD
Length:530
Mass (Da):57,961
Last modified:November 16, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4EDEAD07916D9FC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti153D → N in UW-dbr. 1 Publication1
Natural varianti435S → P in UW-dbr. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF360357 mRNA Translation: AAK81713.1
AK029155 mRNA Translation: BAC26330.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27382.1

NCBI Reference Sequences

More...
RefSeqi
NP_444307.1, NM_053077.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.138278

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000117100; ENSMUSP00000112408; ENSMUSG00000022243

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22293

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:22293

UCSC genome browser

More...
UCSCi
uc007vgx.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF360357 mRNA Translation: AAK81713.1
AK029155 mRNA Translation: BAC26330.1
CCDSiCCDS27382.1
RefSeqiNP_444307.1, NM_053077.3
UniGeneiMm.138278

3D structure databases

ProteinModelPortaliP58355
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022851

Protein family/group databases

TCDBi2.A.2.4.14 the glycoside-pentoside-hexuronide (gph):cation symporter family

PTM databases

iPTMnetiP58355
PhosphoSitePlusiP58355

Proteomic databases

PaxDbiP58355
PRIDEiP58355

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117100; ENSMUSP00000112408; ENSMUSG00000022243
GeneIDi22293
KEGGimmu:22293
UCSCiuc007vgx.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51151
MGIiMGI:2153040 Slc45a2

Phylogenomic databases

eggNOGiKOG0637 Eukaryota
ENOG410XPTR LUCA
GeneTreeiENSGT00940000153826
HOGENOMiHOG000128553
HOVERGENiHBG018570
InParanoidiP58355
KOiK15378
OMAiVSMEPFR
OrthoDBi1230185at2759
PhylomeDBiP58355
TreeFamiTF325412

Enzyme and pathway databases

ReactomeiR-MMU-5662702 Melanin biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Slc45a2 mouse

Protein Ontology

More...
PROi
PR:P58355

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022243 Expressed in 36 organ(s), highest expression level in stria vascularis of cochlear duct
ExpressionAtlasiP58355 baseline and differential
GenevisibleiP58355 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
SUPFAMiSSF103473 SSF103473, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS45A2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58355
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: February 13, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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