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UniProtKB - P58354 (GTR8_BOVIN)
Protein
Solute carrier family 2, facilitated glucose transporter member 8
Gene
SLC2A8
Organism
Bos taurus (Bovine)
Status
Functioni
Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate.
By similarityCatalytic activityi
Activity regulationi
Inhibited by cytochalasin B.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 162 | D-glucoseBy similarity | 1 | |
Binding sitei | 274 | D-glucoseBy similarity | 1 | |
Binding sitei | 395 | D-glucoseBy similarity | 1 |
GO - Molecular functioni
- dehydroascorbic acid transmembrane transporter activity Source: UniProtKB
- fructose transmembrane transporter activity Source: UniProtKB
- glucose transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- dehydroascorbic acid transport Source: UniProtKB
- fructose transmembrane transport Source: UniProtKB
- glucose transmembrane transport Source: UniProtKB
Keywordsi
Biological process | Sugar transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 2, facilitated glucose transporter member 8CuratedAlternative name(s): Glucose transporter type 81 Publication Short name: GLUT-81 Publication Glucose transporter type X1By similarity |
Gene namesi | Name:SLC2A8By similarity Synonyms:GLUT81 Publication, GLUTX1By similarity |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Other locations
- Cytoplasmic vesicle membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration.By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 46 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 47 – 70 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 71 – 91 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 92 – 97 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 98 – 118 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 127 | ExtracellularSequence analysis | 9 | |
Transmembranei | 128 – 148 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 149 – 158 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 159 – 179 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 180 – 182 | ExtracellularSequence analysis | 3 | |
Transmembranei | 183 – 203 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 204 – 257 | CytoplasmicSequence analysisAdd BLAST | 54 | |
Transmembranei | 258 – 278 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 279 – 293 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 294 – 314 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 315 – 320 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 321 – 341 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 342 – 368 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 369 – 389 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 390 – 405 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 406 – 426 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 427 – 439 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 440 – 460 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 461 – 478 | CytoplasmicSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Cell membrane, Cytoplasmic vesicle, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050374 | 1 – 478 | Solute carrier family 2, facilitated glucose transporter member 8Add BLAST | 478 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 350 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | P58354 |
Expressioni
Tissue specificityi
Abundantly expressed in testis and more moderately in lung, kidney, spleen, intestine, skeletal muscle, liver and mammary gland.1 Publication
Inductioni
Up-regulated during pregnancy and lactation.1 Publication
Interactioni
Subunit structurei
Interacts with AP2B1.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000009144 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 268 – 269 | D-glucose bindingBy similarity | 2 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 12 – 13 | Dileucine internalization motifBy similarity | 2 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0254, Eukaryota |
InParanoidi | P58354 |
OrthoDBi | 430696at2759 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 2 hits PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P58354-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPEDQEETQ PLLRPPGGSA PRGRRVFLAA FAAALGPLSF GFALGYSSPA
60 70 80 90 100
IPSLRRAAPP APHLDEDAAS WFGAIVTLGA AAGGVLGGWL LDRAGRKLSL
110 120 130 140 150
VLCALPFVAG FAVITAAQNL WMLLGGRLLT GLACGIASLV APVYISEIAY
160 170 180 190 200
PEVRGLLGSC VQLMVVTGIL LAYLAGWVLE WRWLAVLGCV PPSFMLLLMC
210 220 230 240 250
FMPETPRFLL SQHKHQEAMA AMQFLWGYAQ GWEEPPLGAQ HQDFHVAQLR
260 270 280 290 300
RPGVYKPFII GISLMAFQQL SGVNAVMFYA ETIFEEAKFK DSSLASVVVG
310 320 330 340 350
VIQVLFTATA ALIMDRAGRR LLLTLSGVVM VFSTSAFGTY FKLTEGGPSN
360 370 380 390 400
SSHVDLPALV SMEAADTNVG LAWLAVGSMC LFIAGFAVGW GPIPWLLMSE
410 420 430 440 450
IFPLHVKGVA TGVCVLTNWF MAFLVTKEFS SLMEVLRPYG AFWLASAFCI
460 470
FGVLFTLACV PETKGKTLEQ ITAHFEGR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 191 | P → A in AAK69606 (PubMed:11599048).Curated | 1 | |
Sequence conflicti | 378 | S → N in AAK69606 (PubMed:11599048).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY208940 mRNA Translation: AAP43920.1 BC114811 mRNA Translation: AAI14812.1 AF321324 mRNA Translation: AAK69606.1 |
RefSeqi | NP_963286.1, NM_201528.1 |
Genome annotation databases
GeneIDi | 282867 |
KEGGi | bta:282867 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY208940 mRNA Translation: AAP43920.1 BC114811 mRNA Translation: AAI14812.1 AF321324 mRNA Translation: AAK69606.1 |
RefSeqi | NP_963286.1, NM_201528.1 |
3D structure databases
SMRi | P58354 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000009144 |
Proteomic databases
PaxDbi | P58354 |
Genome annotation databases
GeneIDi | 282867 |
KEGGi | bta:282867 |
Organism-specific databases
CTDi | 29988 |
Phylogenomic databases
eggNOGi | KOG0254, Eukaryota |
InParanoidi | P58354 |
OrthoDBi | 430696at2759 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 2 hits PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GTR8_BOVIN | |
Accessioni | P58354Primary (citable) accession number: P58354 Secondary accession number(s): Q1RMN1, Q6XUI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 23, 2022 | |
This is version 108 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families