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UniProtKB - P58353 (GTR5_BOVIN)
Protein
Solute carrier family 2, facilitated glucose transporter member 5
Gene
SLC2A5
Organism
Bos taurus (Bovine)
Status
Functioni
Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 32 | D-fructoseBy similarity | 1 | |
Binding sitei | 167 | D-fructoseBy similarity | 1 | |
Binding sitei | 288 | D-fructoseBy similarity | 1 | |
Binding sitei | 387 | D-fructoseBy similarity | 1 |
GO - Molecular functioni
- fructose binding Source: UniProtKB
- fructose transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- cellular response to fructose stimulus Source: UniProtKB
- fructose import across plasma membrane Source: UniProtKB
- fructose transmembrane transport Source: GO_Central
- regulation of systemic arterial blood pressure mediated by a chemical signal Source: UniProtKB
- response to fructose Source: UniProtKB
Keywordsi
Biological process | Sugar transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 2, facilitated glucose transporter member 5CuratedAlternative name(s): Fructose transporterCurated Glucose transporter type 5, small intestineBy similarity Short name: GLUT-5By similarity |
Gene namesi | Name:SLC2A5By similarity Synonyms:GLUT5By similarity |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000007302 HostDB:ENSBTAG00000034323 |
Subcellular locationi
Plasma membrane
- Apical cell membrane By similarity; Multi-pass membrane protein By similarity
- Cell membrane Curated; Multi-pass membrane protein 1 Publication
- sarcolemma By similarity
Note: Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A.By similarity
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
- sarcolemma Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 18 | Cytoplasmic1 PublicationAdd BLAST | 18 | |
Transmembranei | 19 – 39 | Helical; Name=11 PublicationAdd BLAST | 21 | |
Topological domaini | 40 – 68 | Extracellular1 PublicationAdd BLAST | 29 | |
Transmembranei | 69 – 91 | Helical; Name=21 PublicationAdd BLAST | 23 | |
Topological domaini | 92 – 98 | Cytoplasmic1 Publication | 7 | |
Transmembranei | 99 – 119 | Helical; Name=31 PublicationAdd BLAST | 21 | |
Topological domaini | 120 – 126 | Extracellular1 Publication | 7 | |
Transmembranei | 127 – 149 | Helical; Name=41 PublicationAdd BLAST | 23 | |
Topological domaini | 150 – 161 | Cytoplasmic1 PublicationAdd BLAST | 12 | |
Transmembranei | 162 – 182 | Helical; Name=51 PublicationAdd BLAST | 21 | |
Topological domaini | 183 – 192 | Extracellular1 Publication | 10 | |
Transmembranei | 193 – 213 | Helical; Name=61 PublicationAdd BLAST | 21 | |
Topological domaini | 214 – 277 | Cytoplasmic1 PublicationAdd BLAST | 64 | |
Transmembranei | 278 – 298 | Helical; Name=71 PublicationAdd BLAST | 21 | |
Topological domaini | 299 – 313 | Extracellular1 PublicationAdd BLAST | 15 | |
Transmembranei | 314 – 334 | Helical; Name=81 PublicationAdd BLAST | 21 | |
Topological domaini | 335 – 342 | Cytoplasmic1 Publication | 8 | |
Transmembranei | 343 – 363 | Helical; Name=91 PublicationAdd BLAST | 21 | |
Topological domaini | 364 – 371 | Extracellular1 Publication | 8 | |
Transmembranei | 372 – 394 | Helical; Name=101 PublicationAdd BLAST | 23 | |
Topological domaini | 395 – 412 | Cytoplasmic1 PublicationAdd BLAST | 18 | |
Transmembranei | 413 – 433 | Helical; Name=111 PublicationAdd BLAST | 21 | |
Topological domaini | 434 – 439 | Extracellular1 Publication | 6 | |
Transmembranei | 440 – 460 | Helical; Name=121 PublicationAdd BLAST | 21 | |
Topological domaini | 461 – 501 | Cytoplasmic1 PublicationAdd BLAST | 41 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050367 | 1 – 501 | Solute carrier family 2, facilitated glucose transporter member 5Add BLAST | 501 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Glycosylationi | 51 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Acetylation, GlycoproteinProteomic databases
PaxDbi | P58353 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P58353 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 296 – 298 | D-fructose bindingBy similarity | 3 | |
Regioni | 419 – 420 | D-fructose bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0569, Eukaryota |
GeneTreei | ENSGT00940000156846 |
HOGENOMi | CLU_001265_30_11_1 |
InParanoidi | P58353 |
OMAi | PTEMRGK |
OrthoDBi | 326501at2759 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002442, Fru_transpt_5 IPR045263, GLUT IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23503, PTHR23503, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01194, GLUCTRSPORT5 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P58353-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPQDPVKRE GRLTPVIVLA TLIAAFGSSF QYGYNVAAIN SPSEFMKDFY
60 70 80 90 100
NYTYYDRVGE YMNEFYLTLL WSVTVSMFPF GGFLGSLMVG PLVNNLGRKG
110 120 130 140 150
TLLFNNIFSI VPALLMGFSE LAKSFEMIIV ARVLVGICAG LSSNVVPMYL
160 170 180 190 200
GELAPKNWRG ALGVVPQLFI TIGILVAQIF GLRSLLANEE GWPILLGLTG
210 220 230 240 250
IPAVLQLLFL PFFPESPRYL LIQKKDEAAA KSALRRLRGW HDVDAEIEEI
260 270 280 290 300
LEEDRAEKAV GFISVLKLFK MRSLRWQVIS IIVLMAGQQL SGVNAIYYYA
310 320 330 340 350
DQIYLSAGVN EDDVQYVTAG TGAVNVLITV CAIFVVELMG RRFLLLLGFS
360 370 380 390 400
VCFTACCVLT GALALQDVIS WMPYVSIACV ISYVIGHALG PSPIPALLVT
410 420 430 440 450
EIFLQSSRPA AYMVAGTVHW LSNFTVGLVF PFIQVGLGAY SFVIFAVICL
460 470 480 490 500
LTTVYIFLII PETKSKTFIE INRIFIKMNK VPGVHPEKEE LKEFPPSTAR
Q
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1M842 | A0A3Q1M842_BOVIN | Fructose transporter | SLC2A5 | 465 | Annotation score: | ||
A0A3Q1MSX8 | A0A3Q1MSX8_BOVIN | Solute carrier family 2, facilitate... | SLC2A5 | 491 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 255 | R → E in AAK63203 (PubMed:11599048).Curated | 1 | |
Sequence conflicti | 353 | F → L in AAK63203 (PubMed:11599048).Curated | 1 | |
Sequence conflicti | 454 | V → I in AAK63203 (PubMed:11599048).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC151530 mRNA Translation: AAI51531.1 AF308830 mRNA Translation: AAK63203.1 |
RefSeqi | NP_001094512.1, NM_001101042.2 |
Genome annotation databases
Ensembli | ENSBTAT00000009606; ENSBTAP00000009606; ENSBTAG00000007302 ENSBTAT00000048616; ENSBTAP00000045621; ENSBTAG00000034323 |
GeneIDi | 282868 |
KEGGi | bta:282868 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC151530 mRNA Translation: AAI51531.1 AF308830 mRNA Translation: AAK63203.1 |
RefSeqi | NP_001094512.1, NM_001101042.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4YB9 | X-ray | 3.20 | D | 1-473 | [»] | |
SMRi | P58353 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000009606 |
Proteomic databases
PaxDbi | P58353 |
Protocols and materials databases
ABCDi | P58353, 1 sequenced antibody |
Genome annotation databases
Ensembli | ENSBTAT00000009606; ENSBTAP00000009606; ENSBTAG00000007302 ENSBTAT00000048616; ENSBTAP00000045621; ENSBTAG00000034323 |
GeneIDi | 282868 |
KEGGi | bta:282868 |
Organism-specific databases
CTDi | 6518 |
VEuPathDBi | HostDB:ENSBTAG00000007302 HostDB:ENSBTAG00000034323 |
Phylogenomic databases
eggNOGi | KOG0569, Eukaryota |
GeneTreei | ENSGT00940000156846 |
HOGENOMi | CLU_001265_30_11_1 |
InParanoidi | P58353 |
OMAi | PTEMRGK |
OrthoDBi | 326501at2759 |
Gene expression databases
ExpressionAtlasi | P58353, baseline |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002442, Fru_transpt_5 IPR045263, GLUT IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23503, PTHR23503, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01194, GLUCTRSPORT5 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GTR5_BOVIN | |
Accessioni | P58353Primary (citable) accession number: P58353 Secondary accession number(s): A7MBF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | February 5, 2008 | |
Last modified: | February 23, 2022 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families