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UniProtKB - P58352 (GTR3_BOVIN)
Protein
Solute carrier family 2, facilitated glucose transporter member 3
Gene
SLC2A3
Organism
Bos taurus (Bovine)
Status
Functioni
Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 159 | D-glucoseBy similarity | 1 | |
Binding sitei | 286 | D-glucoseBy similarity | 1 | |
Binding sitei | 315 | D-glucoseBy similarity | 1 | |
Binding sitei | 378 | D-glucoseBy similarity | 1 | |
Binding sitei | 386 | D-glucoseBy similarity | 1 |
GO - Molecular functioni
- glucose binding Source: UniProtKB
- glucose transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- glucose transmembrane transport Source: UniProtKB
Keywordsi
Biological process | Sugar transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 2, facilitated glucose transporter member 3CuratedAlternative name(s): Glucose transporter type 3, brain1 Publication Short name: GLUT-31 Publication |
Gene namesi | Name:SLC2A3By similarity Synonyms:GLUT31 Publication |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- Perikaryon By similarity
- Cell projection By similarity
Note: Localized to densely spaced patches along neuronal processes.By similarity
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
Other locations
- cell projection Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB
- perikaryon Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | CytoplasmicBy similarity | 10 | |
Transmembranei | 11 – 32 | Helical; Name=1Sequence analysisBy similarityAdd BLAST | 22 | |
Topological domaini | 33 – 64 | ExtracellularBy similarityAdd BLAST | 32 | |
Transmembranei | 65 – 85 | Helical; Name=2Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 86 – 90 | CytoplasmicBy similarity | 5 | |
Transmembranei | 91 – 111 | Helical; Name=3Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 112 – 118 | ExtracellularBy similarity | 7 | |
Transmembranei | 119 – 142 | Helical; Name=4Sequence analysisBy similarityAdd BLAST | 24 | |
Topological domaini | 143 – 153 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 154 – 174 | Helical; Name=5Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 175 – 183 | ExtracellularBy similarity | 9 | |
Transmembranei | 184 – 204 | Helical; Name=6Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 205 – 269 | CytoplasmicBy similarityAdd BLAST | 65 | |
Transmembranei | 270 – 290 | Helical; Name=7Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 291 – 304 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 305 – 325 | Helical; Name=8Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 326 – 331 | CytoplasmicBy similarity | 6 | |
Transmembranei | 332 – 352 | Helical; Name=9Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 353 – 363 | ExtracellularBy similarityAdd BLAST | 11 | |
Transmembranei | 364 – 389 | Helical; Name=10Sequence analysisBy similarityAdd BLAST | 26 | |
Topological domaini | 390 – 399 | CytoplasmicBy similarity | 10 | |
Transmembranei | 400 – 420 | Helical; Name=11Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 421 – 429 | ExtracellularBy similarity | 9 | |
Transmembranei | 430 – 450 | Helical; Name=12Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 451 – 494 | CytoplasmicBy similarityAdd BLAST | 44 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050351 | 1 – 494 | Solute carrier family 2, facilitated glucose transporter member 3Add BLAST | 494 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 232 | PhosphothreonineBy similarity | 1 | |
Glycosylationi | 358 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 485 | PhosphoserineBy similarity | 1 | |
Modified residuei | 492 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P58352 |
PRIDEi | P58352 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 277 – 279 | Important for selectivity against fructoseBy similarity | 3 | |
Regioni | 280 – 281 | D-glucose bindingBy similarity | 2 | |
Regioni | 469 – 494 | DisorderedSequence analysisAdd BLAST | 26 |
Domaini
Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.By similarity
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0569, Eukaryota |
InParanoidi | P58352 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002945, Glc_transpt_3 IPR045263, GLUT IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23503, PTHR23503, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01192, GLUCTRSPORT3 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P58352-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTTKVTAPL IFAISVATIG SFQFGYNTGV INAPEAIIKD FLNYTLEERS
60 70 80 90 100
EPPPSSVLLT SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR GNSMLIVNLL
110 120 130 140 150
AIAGGCLMGF CKIAESVEML ILGRLIIGLF CGLCTGFVPM YIGEISPTAL
160 170 180 190 200
RGAFGTLNQL GIVIGILVAQ IFGLKVILGT EDLWPLLLGF TILPAIIQCA
210 220 230 240 250
ALPFCPESPR FLLINRKEEE KAKEILQRLW GTEDVAQDIQ EMKDESMRMS
260 270 280 290 300
QEKQVTVLEL FRAPNYRQPI IISIMLQLSQ QLSGINAVFY YSTGIFKDAG
310 320 330 340 350
VQEPVYATIG AGVVNTIFTV VSVFLVERAG RRTLHLIGLG GMAFCSILMT
360 370 380 390 400
ISLLLKDNYS WMSFICIGAI LVFVAFFEIG PGPIPWFIVA ELFGQGPRPA
410 420 430 440 450
AMAVAGCSNW TSNFLVGLLF PSAAFYLGAY VFIVFTVFLV IFWVFTFFKV
460 470 480 490
PETRGRTFEE ITRAFEGQTQ TGTRGEKGPI MEMNSIQPTK DTNA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 385 – 389 | PWFIV → SLVYC in AAK63202 (Ref. 2) Curated | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY033938 mRNA Translation: AAK70222.1 AF308829 mRNA Translation: AAK63202.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY033938 mRNA Translation: AAK70222.1 AF308829 mRNA Translation: AAK63202.1 |
3D structure databases
SMRi | P58352 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000040493 |
Proteomic databases
PaxDbi | P58352 |
PRIDEi | P58352 |
Phylogenomic databases
eggNOGi | KOG0569, Eukaryota |
InParanoidi | P58352 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002945, Glc_transpt_3 IPR045263, GLUT IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23503, PTHR23503, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01192, GLUCTRSPORT3 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GTR3_BOVIN | |
Accessioni | P58352Primary (citable) accession number: P58352 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | November 16, 2001 | |
Last modified: | February 23, 2022 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families