UniProtKB - P58351 (GTR2_BOVIN)
Solute carrier family 2, facilitated glucose transporter member 2
SLC2A2
Functioni
Facilitative hexose transporter that mediates the transport of glucose and fructose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate.
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 191 | D-glucoseBy similarity | 1 | |
Binding sitei | 318 | D-glucoseBy similarity | 1 | |
Binding sitei | 347 | D-glucoseBy similarity | 1 | |
Binding sitei | 410 | D-glucoseBy similarity | 1 | |
Binding sitei | 418 | D-glucoseBy similarity | 1 |
GO - Molecular functioni
- dehydroascorbic acid transmembrane transporter activity Source: UniProtKB
- D-glucose transmembrane transporter activity Source: Ensembl
- fructose transmembrane transporter activity Source: UniProtKB
- glucose transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- fructose transmembrane transport Source: UniProtKB
- glucose transmembrane transport Source: UniProtKB
Keywordsi
Biological process | Sugar transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 2, facilitated glucose transporter member 2CuratedAlternative name(s): Glucose transporter type 2, liverBy similarity Short name: GLUT-21 Publication |
Gene namesi | |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000005386 |
VGNCi | VGNC:34800, SLC2A2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- apical plasma membrane Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- brush border Source: Ensembl
- cell-cell junction Source: Ensembl
- cytoplasm Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 11 – 31 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 32 – 96 | ExtracellularSequence analysisAdd BLAST | 65 | |
Transmembranei | 97 – 117 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 118 – 122 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 123 – 143 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 144 – 157 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 158 – 178 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 179 – 191 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 192 – 212 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 215 | ExtracellularSequence analysis | 3 | |
Transmembranei | 216 – 236 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 237 – 301 | CytoplasmicSequence analysisAdd BLAST | 65 | |
Transmembranei | 302 – 322 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 323 – 336 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 337 – 357 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 358 – 365 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 366 – 386 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 387 – 400 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 401 – 421 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 422 – 431 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 432 – 452 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 453 – 454 | ExtracellularSequence analysis | 2 | |
Transmembranei | 455 – 475 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 476 – 510 | CytoplasmicSequence analysisAdd BLAST | 35 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050345 | 1 – 510 | Solute carrier family 2, facilitated glucose transporter member 2Add BLAST | 510 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 62 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | P58351 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000005386, Expressed in liver and 21 other tissues |
ExpressionAtlasi | P58351, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 312 – 313 | D-glucose bindingBy similarity | 2 | |
Regioni | 490 – 510 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0569, Eukaryota |
GeneTreei | ENSGT00940000155708 |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | P58351 |
OMAi | PQCIPMN |
OrthoDBi | 430696at2759 |
TreeFami | TF313762 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002440, Glc_transpt_2 IPR045263, GLUT IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23503, PTHR23503, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01191, GLUCTRSPORT2 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MTEDKVTGTL VLAVFTAVLS SFQFGYDIGV INAPQQVIIT HYRHVLGVSL
60 70 80 90 100
DDRIAINNYA LNSTEELPTS LGDPTPVSWA EEETMTSASL ITMFWSLSVS
110 120 130 140 150
SFAVGGMIAS FFGGLLGDKL GRIKALLVAN ILSLVGALLM GFSKLGPSHI
160 170 180 190 200
LIISGRGISG LYCGLISGLI PMYIGEIAPT TLRGAIGALH QLAIVTGILI
210 220 230 240 250
SQIVGLDFIL GNHELWHILL GLSAVPAILQ CLLLFFCPES PRYLYIKLDE
260 270 280 290 300
EAKAKKSLKR LRGSDDITKD ITEMRKEREE ASNEKKVSII QLFTNASYRQ
310 320 330 340 350
PILVALMLHA AQQFSGINGI FYYSTSIFQT AGISQPVYAT IGVGAVNTVF
360 370 380 390 400
TAVSVFLVEK AGRRSLFLIG MSGMFVCAIF MSVGLVLLSK FPWMNYVSMT
410 420 430 440 450
AIFLFVSFFE IGPGPIPWFM VAEFFSQGPR PAALAIAAFS NWTGNFIIAL
460 470 480 490 500
CFQYIADFCG PYVFFLLLVW SWPLFCSHFL KFQKPKENPL RKSQQSSERR
510
GVQLKRQKLL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1N3G2 | A0A3Q1N3G2_BOVIN | Glucose transporter type 2, liver | SLC2A2 | 494 | Annotation score: | ||
A0A3Q1MH78 | A0A3Q1MH78_BOVIN | Glucose transporter type 2, liver | SLC2A2 | 488 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 258 | L → W in AAK63201 (PubMed:11599048).Curated | 1 | |
Sequence conflicti | 278 | R → G in AAK63201 (PubMed:11599048).Curated | 1 | |
Sequence conflicti | 395 | N → S in AAK63201 (PubMed:11599048).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC149324 mRNA Translation: AAI49325.1 AF308828 mRNA Translation: AAK63201.1 |
RefSeqi | NP_001096692.1, NM_001103222.1 |
Genome annotation databases
Ensembli | ENSBTAT00000055725; ENSBTAP00000050612; ENSBTAG00000005386 |
GeneIDi | 282357 |
KEGGi | bta:282357 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC149324 mRNA Translation: AAI49325.1 AF308828 mRNA Translation: AAK63201.1 |
RefSeqi | NP_001096692.1, NM_001103222.1 |
3D structure databases
SMRi | P58351 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000050612 |
Proteomic databases
PaxDbi | P58351 |
Genome annotation databases
Ensembli | ENSBTAT00000055725; ENSBTAP00000050612; ENSBTAG00000005386 |
GeneIDi | 282357 |
KEGGi | bta:282357 |
Organism-specific databases
CTDi | 6514 |
VEuPathDBi | HostDB:ENSBTAG00000005386 |
VGNCi | VGNC:34800, SLC2A2 |
Phylogenomic databases
eggNOGi | KOG0569, Eukaryota |
GeneTreei | ENSGT00940000155708 |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | P58351 |
OMAi | PQCIPMN |
OrthoDBi | 430696at2759 |
TreeFami | TF313762 |
Gene expression databases
Bgeei | ENSBTAG00000005386, Expressed in liver and 21 other tissues |
ExpressionAtlasi | P58351, baseline and differential |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002440, Glc_transpt_2 IPR045263, GLUT IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23503, PTHR23503, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01191, GLUCTRSPORT2 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GTR2_BOVIN | |
Accessioni | P58351Primary (citable) accession number: P58351 Secondary accession number(s): A6QPH3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | February 10, 2009 | |
Last modified: | February 23, 2022 | |
This is version 121 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families