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Protein

Krueppel-like factor 16

Gene

Klf16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds GC and GT boxes in the D1A, D2 and D3 dopamine receptor promoters and displaces Sp1 and Sp3 from these sequences. It modulates dopaminergic transmission in the brain by repressing or activating transcription from several different promoters depending on cellular context.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri126 – 150C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri156 – 180C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri186 – 208C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 16
Alternative name(s):
Basic transcription element-binding protein 4
Short name:
BTE-binding protein 4
Dopamine receptor-regulating factor
Transcription factor BTEB4
Gene namesi
Name:Klf16
Synonyms:Bteb4, Drrf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2153049 Klf16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471591 – 251Krueppel-like factor 16Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103PhosphoserineCombined sources1
Modified residuei151PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP58334
MaxQBiP58334
PaxDbiP58334
PRIDEiP58334

PTM databases

iPTMnetiP58334
PhosphoSitePlusiP58334

Expressioni

Tissue specificityi

High expression in brain; olfactory tubercle, olfactory bulb, nucleus accumbens, striatum, hippocampal CA1 region, amygdala, dentate gyrus and frontal cortex. Moderate expression in hippocampal CA2-3 regions, piriform cortex, septum, and distinct thalamic nuclei. Low expression in the cerebellum.

Gene expression databases

BgeeiENSMUSG00000035397 Expressed in 244 organ(s), highest expression level in visual cortex
CleanExiMM_KLF16
ExpressionAtlasiP58334 baseline and differential
GenevisibleiP58334 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048825

Structurei

3D structure databases

ProteinModelPortaliP58334
SMRiP58334
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 136Ala/Pro-richAdd BLAST134
Compositional biasi103 – 116Ser-richAdd BLAST14
Compositional biasi223 – 248Pro/Ser-richAdd BLAST26

Domaini

The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri126 – 150C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri156 – 180C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri186 – 208C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000233575
HOVERGENiHBG050746
InParanoidiP58334
KOiK09208
OMAiPMSAYSE
OrthoDBiEOG091G1BN0
PhylomeDBiP58334
TreeFamiTF351003

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

P58334-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAVACVDY FAADVLMAIS SGAVVHRGRP GPEGAGPAAG LDVRATRREA
60 70 80 90 100
TPPGTPGAPP PPATAPGPGG ATAAPHLLAA SILADLRGGP VVATAASTAG
110 120 130 140 150
GTSPVSSSSA ASSPSSGRAP GAAKSHRCPF HGCAKAYYKS SHLKSHLRTH
160 170 180 190 200
TGERPFACDW PGCDKKFARS DELARHHRTH TGEKRFPCPL CTKRFTRSDH
210 220 230 240 250
LTKHARRHPG FRPELLRRPG ARSVSPSDSL PCSLAGSPTP SPVPSPAPAG

L
Length:251
Mass (Da):25,652
Last modified:August 16, 2004 - v2
Checksum:i3F0D7739BF7B1FA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283891 mRNA Translation: AAK66968.1
AK044577 mRNA Translation: BAC31987.1
AK154524 mRNA Translation: BAE32651.1
CCDSiCCDS24026.1
RefSeqiNP_510962.2, NM_078477.2
UniGeneiMm.41513

Genome annotation databases

EnsembliENSMUST00000038558; ENSMUSP00000048825; ENSMUSG00000035397
GeneIDi118445
KEGGimmu:118445
UCSCiuc007gdt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283891 mRNA Translation: AAK66968.1
AK044577 mRNA Translation: BAC31987.1
AK154524 mRNA Translation: BAE32651.1
CCDSiCCDS24026.1
RefSeqiNP_510962.2, NM_078477.2
UniGeneiMm.41513

3D structure databases

ProteinModelPortaliP58334
SMRiP58334
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048825

PTM databases

iPTMnetiP58334
PhosphoSitePlusiP58334

Proteomic databases

EPDiP58334
MaxQBiP58334
PaxDbiP58334
PRIDEiP58334

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038558; ENSMUSP00000048825; ENSMUSG00000035397
GeneIDi118445
KEGGimmu:118445
UCSCiuc007gdt.1 mouse

Organism-specific databases

CTDi83855
MGIiMGI:2153049 Klf16

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000233575
HOVERGENiHBG050746
InParanoidiP58334
KOiK09208
OMAiPMSAYSE
OrthoDBiEOG091G1BN0
PhylomeDBiP58334
TreeFamiTF351003

Miscellaneous databases

PROiPR:P58334
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035397 Expressed in 244 organ(s), highest expression level in visual cortex
CleanExiMM_KLF16
ExpressionAtlasiP58334 baseline and differential
GenevisibleiP58334 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF16_MOUSE
AccessioniPrimary (citable) accession number: P58334
Secondary accession number(s): Q3U3Y4, Q8C8S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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