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UniProtKB - P58312 (AT1A3_OREMO)
Protein
Sodium/potassium-transporting ATPase subunit alpha-3
Gene
atp1a3
Organism
Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)
Status
Functioni
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Catalytic activityi
- EC:7.2.2.13
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 363 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 704 | MagnesiumBy similarity | 1 | |
Metal bindingi | 708 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- P-type sodium:potassium-exchanging transporter activity Source: UniProtKB
Keywordsi
Molecular function | Translocase |
Biological process | Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/potassium-transporting ATPase subunit alpha-3 (EC:7.2.2.13)Short name: Na(+)/K(+) ATPase alpha-3 subunit Alternative name(s): Na(+)/K(+) ATPase alpha(III) subunit Sodium pump subunit alpha-3 |
Gene namesi | Name:atp1a3 |
Organismi | Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica) |
Taxonomic identifieri | 8127 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Neoteleostei › Acanthomorphata › Ovalentaria › Cichlomorphae › Cichliformes › Cichlidae › African cichlids › Pseudocrenilabrinae › Oreochromini › Oreochromis |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- synapse Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 74 | CytoplasmicSequence analysisAdd BLAST | 74 | |
Transmembranei | 75 – 95 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 96 – 118 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 119 – 139 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 140 – 275 | CytoplasmicSequence analysisAdd BLAST | 136 | |
Transmembranei | 276 – 295 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 296 – 307 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 308 – 325 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 326 – 759 | CytoplasmicSequence analysisAdd BLAST | 434 | |
Transmembranei | 760 – 779 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 780 – 789 | ExtracellularSequence analysis | 10 | |
Transmembranei | 790 – 810 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 811 – 830 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 831 – 853 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 854 – 905 | ExtracellularSequence analysisAdd BLAST | 52 | |
Transmembranei | 906 – 925 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 926 – 938 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 939 – 957 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 958 – 972 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 973 – 993 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 994 – 1010 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046302 | 1 – 1010 | Sodium/potassium-transporting ATPase subunit alpha-3Add BLAST | 1010 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 930 | Phosphoserine; by PKABy similarity | 1 |
Keywords - PTMi
PhosphoproteinInteractioni
Subunit structurei
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
CuratedFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 69 – 71 | Interaction with phosphoinositide-3 kinaseBy similarity | 3 | |
Regioni | 201 – 221 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 201 – 219 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
P58312-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDKDDRFPK KKKGGTKDMD ALKKEVPITE HKMSVEEVCR KFQTDVVQGL
60 70 80 90 100
TNAKAAEFLL RDGPNALTPP PTTPEWVKFC RQLFGGFSIL LWTGAILCFL
110 120 130 140 150
AYAIQAATED EPAGDNLYLG IVLTAVVVIT GCFSYFQEAK SSKIMESFKN
160 170 180 190 200
MVPQQALVIR EGEKVQVNAE EVMAGDLIEV KGGDRIPADI RVTSAHGCKV
210 220 230 240 250
DNSSLTGESE PQSRSPDCTH DNPLETRNIA FFSTNCVEGT ARGIVICTGD
260 270 280 290 300
RTVMGRIATL TSGLETGKTP IAVEIEHFIH IITGVAVFLG VTFFILAIIL
310 320 330 340 350
GYTWLKAVIF LIGIIVANVP EGLLATVTVC LTLTAKRMAK KNCLVKNLEA
360 370 380 390 400
VETLGSTSTI CSDKTGTLTQ NRMTVAHMWF DNQIHEADTT EDQSGAAFDK
410 420 430 440 450
SSVTWLSLSR VAPLCNRAQF KPRQDSVSIL KRDVAGDASE SALLKCIELS
460 470 480 490 500
CGSVRMMRDK NKKVAEIPFN PTNKYQLSIH ETEDPNDNRY LLVMKGALER
510 520 530 540 550
ILDRCSTIML QGKEQPMDEE MKEAFQNAYM ELGGLGERVL GFRHLLLPED
560 570 580 590 600
QYPKGFAFDT DDVNFQTDNL CFVGLMSMID PPRAAVPDAV GKCRSAGIKV
610 620 630 640 650
IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS QVNPRDAKAC
660 670 680 690 700
VIHGSDLKDL SQDQMDDILR NHTEIVFART SPQQKLIIVE GCQRLGAIVA
710 720 730 740 750
VTGDGVNDSP ALKKADIGVA MGISGSDVSK QAADMILLDD NFASIVTGVE
760 770 780 790 800
EGRLIFDNLK KSIAYTLTSN IPEITPFLFF IIVNIPLALG TITILCIDLG
810 820 830 840 850
TDMGSAISLA YETAESDIMK RQPRNPCRDK LVNERLISIA YGQIGMIQAL
860 870 880 890 900
GGFFSYFVIL AENGFLPSQL VGIRLNWDDR SLNDLEDSYG QQWTYEQRKI
910 920 930 940 950
VEFTCHTAFF VSIVVVQWAD LIICKTRRNS VFQQGMKNKI LIFGLFEETA
960 970 980 990 1000
LAAFLSYCPG MDVALRMYPL KPTWWFWAFP YSFLIFVYDE ARKLILCRNP
1010
GGWVEKETYY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF109409 mRNA Translation: AAF75108.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF109409 mRNA Translation: AAF75108.1 |
3D structure databases
SMRi | P58312 |
ModBasei | Search... |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT1A3_OREMO | |
Accessioni | P58312Primary (citable) accession number: P58312 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | October 18, 2001 | |
Last modified: | February 23, 2022 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |