UniProtKB - P58294 (PROK1_HUMAN)
Protein
Prokineticin-1
Gene
PROK1
Organism
Homo sapiens (Human)
Status
Functioni
Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.5 Publications
GO - Molecular functioni
- G protein-coupled receptor binding Source: GO_Central
- growth factor activity Source: UniProtKB-KW
GO - Biological processi
- activation of MAPK activity Source: GO_Central
- angiogenesis Source: UniProtKB-KW
- circadian rhythm Source: GO_Central
- G protein-coupled receptor signaling pathway Source: Reactome
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell population proliferation Source: GO_Central
- regulation of angiogenesis Source: GO_Central
Keywordsi
Molecular function | Growth factor, Mitogen |
Biological process | Angiogenesis |
Enzyme and pathway databases
PathwayCommonsi | P58294 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P58294 |
Names & Taxonomyi
Protein namesi | Recommended name: Prokineticin-1Alternative name(s): Endocrine-gland-derived vascular endothelial growth factor Short name: EG-VEGF Mambakine |
Gene namesi | Name:PROK1 ORF Names:UNQ600/PRO1186 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18454, PROK1 |
MIMi | 606233, gene |
neXtProti | NX_P58294 |
VEuPathDBi | HostDB:ENSG00000143125.5 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 84432 |
OpenTargetsi | ENSG00000143125 |
PharmGKBi | PA38539 |
Miscellaneous databases
Pharosi | P58294, Tbio |
Genetic variation databases
BioMutai | PROK1 |
DMDMi | 17380189 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000025807 | 20 – 105 | Prokineticin-1Add BLAST | 86 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 ↔ 38 | By similarity | ||
Disulfide bondi | 32 ↔ 50 | By similarity | ||
Disulfide bondi | 37 ↔ 78 | By similarity | ||
Disulfide bondi | 60 ↔ 86 | By similarity | ||
Disulfide bondi | 80 ↔ 96 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P58294 |
PRIDEi | P58294 |
ProteomicsDBi | 57057 |
PTM databases
iPTMneti | P58294 |
PhosphoSitePlusi | P58294 |
Expressioni
Tissue specificityi
Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.3 Publications
Developmental stagei
In adult testis, is strongly expressed only in Leydig cells. In testicular tumors, expressed specifically in Leydig cell tumors (at protein level). Expressed from 14 weeks until birth in fetal testis.
Gene expression databases
Bgeei | ENSG00000143125, Expressed in right ovary and 98 other tissues |
ExpressionAtlasi | P58294, baseline and differential |
Genevisiblei | P58294, HS |
Organism-specific databases
HPAi | ENSG00000143125, Group enriched (ovary, testis) |
Interactioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: GO_Central
- growth factor activity Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 9606.ENSP00000271331 |
Miscellaneous databases
RNActi | P58294, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the AVIT (prokineticin) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S1PW, Eukaryota |
GeneTreei | ENSGT00940000161331 |
HOGENOMi | CLU_143202_2_0_1 |
InParanoidi | P58294 |
OMAi | FSHKVPY |
OrthoDBi | 1517288at2759 |
PhylomeDBi | P58294 |
TreeFami | TF332732 |
Family and domain databases
InterProi | View protein in InterPro IPR009523, Prokineticin IPR023569, Prokineticin_domain |
PANTHERi | PTHR18821, PTHR18821, 1 hit |
Pfami | View protein in Pfam PF06607, Prokineticin, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P58294-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGATRVSIM LLLVTVSDCA VITGACERDV QCGAGTCCAI SLWLRGLRMC
60 70 80 90 100
TPLGREGEEC HPGSHKVPFF RKRKHHTCPC LPNLLCSRFP DGRYRCSMDL
KNINF
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053610 | 67 | V → I1 PublicationCorresponds to variant dbSNP:rs7514102Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF333024 mRNA Translation: AAK49918.1 AY029225 mRNA Translation: AAK33111.1 AY358683 mRNA Translation: AAQ89046.1 AL358215 Genomic DNA No translation available. AL390797 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56449.1 BC025399 mRNA Translation: AAH25399.1 |
CCDSi | CCDS825.1 |
RefSeqi | NP_115790.1, NM_032414.2 |
Genome annotation databases
Ensembli | ENST00000271331; ENSP00000271331; ENSG00000143125 |
GeneIDi | 84432 |
KEGGi | hsa:84432 |
UCSCi | uc001dzs.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF333024 mRNA Translation: AAK49918.1 AY029225 mRNA Translation: AAK33111.1 AY358683 mRNA Translation: AAQ89046.1 AL358215 Genomic DNA No translation available. AL390797 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56449.1 BC025399 mRNA Translation: AAH25399.1 |
CCDSi | CCDS825.1 |
RefSeqi | NP_115790.1, NM_032414.2 |
3D structure databases
SMRi | P58294 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000271331 |
PTM databases
iPTMneti | P58294 |
PhosphoSitePlusi | P58294 |
Genetic variation databases
BioMutai | PROK1 |
DMDMi | 17380189 |
Proteomic databases
PaxDbi | P58294 |
PRIDEi | P58294 |
ProteomicsDBi | 57057 |
Protocols and materials databases
Antibodypediai | 20098, 311 antibodies |
DNASUi | 84432 |
Genome annotation databases
Ensembli | ENST00000271331; ENSP00000271331; ENSG00000143125 |
GeneIDi | 84432 |
KEGGi | hsa:84432 |
UCSCi | uc001dzs.4, human |
Organism-specific databases
CTDi | 84432 |
DisGeNETi | 84432 |
GeneCardsi | PROK1 |
HGNCi | HGNC:18454, PROK1 |
HPAi | ENSG00000143125, Group enriched (ovary, testis) |
MIMi | 606233, gene |
neXtProti | NX_P58294 |
OpenTargetsi | ENSG00000143125 |
PharmGKBi | PA38539 |
VEuPathDBi | HostDB:ENSG00000143125.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1PW, Eukaryota |
GeneTreei | ENSGT00940000161331 |
HOGENOMi | CLU_143202_2_0_1 |
InParanoidi | P58294 |
OMAi | FSHKVPY |
OrthoDBi | 1517288at2759 |
PhylomeDBi | P58294 |
TreeFami | TF332732 |
Enzyme and pathway databases
PathwayCommonsi | P58294 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P58294 |
Miscellaneous databases
BioGRID-ORCSi | 84432, 11 hits in 974 CRISPR screens |
GenomeRNAii | 84432 |
Pharosi | P58294, Tbio |
PROi | PR:P58294 |
RNActi | P58294, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143125, Expressed in right ovary and 98 other tissues |
ExpressionAtlasi | P58294, baseline and differential |
Genevisiblei | P58294, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009523, Prokineticin IPR023569, Prokineticin_domain |
PANTHERi | PTHR18821, PTHR18821, 1 hit |
Pfami | View protein in Pfam PF06607, Prokineticin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PROK1_HUMAN | |
Accessioni | P58294Primary (citable) accession number: P58294 Secondary accession number(s): Q5VWD4, Q8TC69 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | September 26, 2001 | |
Last modified: | April 7, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families