UniProtKB - P58215 (LOXL3_HUMAN)
Protein
Lysyl oxidase homolog 3
Gene
LOXL3
Organism
Homo sapiens (Human)
Status
Functioni
Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600).By similarity2 Publications
Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII (PubMed:17018530).1 Publication
Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV (PubMed:17018530).1 Publication
Catalytic activityi
- EC:1.4.3.131 Publication
- H2O + N6-acetyl-L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O21 Publication
Cofactori
Protein has several cofactor binding sites:- Cu cationBy similarity
- lysine tyrosylquinone residueBy similarityNote: Contains 1 lysine tyrosylquinone.By similarity
Kineticsi
kcat is 0.058 sec(-1) with STAT3 acetylated at 'Lys-685' (for deacetylation activity). kcat is 0.022 sec(-1) with STAT3 acetylated at 'Lys-685' (for lysine 6-oxidase activity).1 Publication
- KM=6.72 µM for STAT3 acetylated at 'Lys-685' (for deacetylation activity)1 Publication
- KM=1.59 µM for STAT3 acetylated at 'Lys-685' (for lysine 6-oxidase activity)1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 607 | CopperSequence analysis | 1 | |
Metal bindingi | 609 | CopperSequence analysis | 1 | |
Metal bindingi | 611 | CopperSequence analysis | 1 |
GO - Molecular functioni
- copper ion binding Source: UniProtKB
- fibronectin binding Source: UniProtKB
- protein-lysine 6-oxidase activity Source: UniProtKB
- scavenger receptor activity Source: InterPro
GO - Biological processi
- collagen fibril organization Source: GO_Central
- epithelial to mesenchymal transition Source: UniProtKB
- fibronectin fibril organization Source: UniProtKB
- inflammatory response Source: UniProtKB
- lung development Source: UniProtKB
- negative regulation of T-helper 17 cell lineage commitment Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- peptidyl-lysine oxidation Source: UniProtKB
- positive regulation of integrin-mediated signaling pathway Source: UniProtKB
- roof of mouth development Source: UniProtKB
- somite development Source: UniProtKB
- spinal cord development Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Inflammatory response |
Ligand | Copper, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000115318-MONOMER |
BRENDAi | 1.4.3.13, 2681 |
PathwayCommonsi | P58215 |
Reactomei | R-HSA-1566948, Elastic fibre formation R-HSA-2243919, Crosslinking of collagen fibrils |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13869, LOXL3 |
MIMi | 607163, gene |
neXtProti | NX_P58215 |
VEuPathDBi | HostDB:ENSG00000115318.11 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 1 Publication
Extracellular region or secreted
- extracellular space By similarity
Note: It is unclear how LOXL3 is both intracellular (cytoplasmic and nuclear) and extracellular: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, the intracellular location is clearly reported and at least another protein of the family (LOXL2) also has intracellular and extracellular localization despite the presence of a signal sequence (PubMed:28065600).1 Publication
Extracellular region or secreted
- extracellular space Curated
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Extracellular region or secreted
- extracellular space 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cytoplasm, Nucleus, SecretedPathology & Biotechi
Involvement in diseasei
Defects in LOXL3 are found in a family with an autosomal recessive form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence and sensorineural deafness (PubMed:25663169). Pierre Robin sequence includes an opening in the roof of the mouth (a cleft palate) (PubMed:25663169). The degree of hearing loss varies among affected individuals and may become more severe over time (PubMed:25663169). Syndrome expressivity is variable (PubMed:25663169). Ocular disorders include non-progressive myopia with associated chorioretinal degeneration (PubMed:25663169). Defects in LOXL3 are found in another family with early-onset high myopia (PubMed:26957899). The disease may be caused by variants affecting the gene represented in this entry (PubMed:25663169, PubMed:26957899).2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 83 | C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-214; A-345 and A-459. 1 Publication | 1 | |
Mutagenesisi | 214 | C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-83; A-345 and A-459. 1 Publication | 1 | |
Mutagenesisi | 345 | C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-83; A-214 and A-459. 1 Publication | 1 | |
Mutagenesisi | 376 | C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-446 and A-492. 1 Publication | 1 | |
Mutagenesisi | 446 | C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-376 and A-492. 1 Publication | 1 | |
Mutagenesisi | 459 | C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-83; A-214 and A-345. 1 Publication | 1 | |
Mutagenesisi | 492 | C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-376 and A-446. 1 Publication | 1 | |
Mutagenesisi | 607 – 609 | HGH → QGQ: Impaired ability to mediate deacetylation of STAT3. 1 Publication | 3 |
Keywords - Diseasei
Deafness, Stickler syndromeOrganism-specific databases
DisGeNETi | 84695 |
MalaCardsi | LOXL3 |
OpenTargetsi | ENSG00000115318 |
Orphaneti | 250984, Autosomal recessive Stickler syndrome |
PharmGKBi | PA30430 |
Miscellaneous databases
Pharosi | P58215, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105989 |
Genetic variation databases
BioMutai | LOXL3 |
DMDMi | 14916616 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000018533 | 26 – 753 | Lysyl oxidase homolog 3Add BLAST | 728 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 70 ↔ 134 | PROSITE-ProRule annotation | ||
Disulfide bondi | 83 ↔ 144 | PROSITE-ProRule annotation | ||
Glycosylationi | 111 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 114 ↔ 124 | PROSITE-ProRule annotation | ||
Disulfide bondi | 201 ↔ 271 | PROSITE-ProRule annotation | ||
Disulfide bondi | 214 ↔ 281 | PROSITE-ProRule annotation | ||
Disulfide bondi | 248 ↔ 258 | PROSITE-ProRule annotation | ||
Glycosylationi | 266 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 332 ↔ 396 | PROSITE-ProRule annotation | ||
Disulfide bondi | 345 ↔ 406 | PROSITE-ProRule annotation | ||
Disulfide bondi | 376 ↔ 386 | PROSITE-ProRule annotation | ||
Glycosylationi | 390 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 446 ↔ 511 | PROSITE-ProRule annotation | ||
Disulfide bondi | 459 ↔ 524 | PROSITE-ProRule annotation | ||
Glycosylationi | 481 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 492 ↔ 502 | PROSITE-ProRule annotation | ||
Disulfide bondi | 554 ↔ 560 | PROSITE-ProRule annotation | ||
Disulfide bondi | 606 ↔ 654 | PROSITE-ProRule annotation | ||
Glycosylationi | 625 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Cross-linki | 634 ↔ 670 | Lysine tyrosylquinone (Lys-Tyr)By similarity | ||
Disulfide bondi | 638 ↔ 644 | PROSITE-ProRule annotation | ||
Disulfide bondi | 666 ↔ 676 | PROSITE-ProRule annotation | ||
Modified residuei | 670 | 2',4',5'-topaquinoneBy similarity | 1 | |
Disulfide bondi | 713 ↔ 727 | PROSITE-ProRule annotation |
Post-translational modificationi
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, LTQ, TPQProteomic databases
jPOSTi | P58215 |
MassIVEi | P58215 |
PaxDbi | P58215 |
PeptideAtlasi | P58215 |
PRIDEi | P58215 |
ProteomicsDBi | 57056 [P58215-1] 66450 |
PTM databases
GlyConnecti | 1481, 3 N-Linked glycans (1 site) |
GlyGeni | P58215, 5 sites |
iPTMneti | P58215 |
PhosphoSitePlusi | P58215 |
Expressioni
Tissue specificityi
Isoform 1: Predominantly detected in the heart, placenta, lung, and small intestine (PubMed:17018530). Isoform 2: Highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung (PubMed:17018530). In eye, present in all layers of corneas as well as in the limbus and conjunctiva (at protein level) (PubMed:26218558).2 Publications
Gene expression databases
Bgeei | ENSG00000115318, Expressed in tibia and 180 other tissues |
ExpressionAtlasi | P58215, baseline and differential |
Genevisiblei | P58215, HS |
Organism-specific databases
HPAi | ENSG00000115318, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with STAT3 (PubMed:28065600).
1 PublicationBinary interactionsi
P58215
With | #Exp. | IntAct |
---|---|---|
Adamtsl2 [Q7TSK7] from Mus musculus. | 2 | EBI-723960,EBI-25406979 |
GO - Molecular functioni
- fibronectin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 124210, 12 interactors |
IntActi | P58215, 5 interactors |
STRINGi | 9606.ENSP00000264094 |
Chemistry databases
BindingDBi | P58215 |
Miscellaneous databases
RNActi | P58215, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 145 | SRCR 1PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 169 – 282 | SRCR 2PROSITE-ProRule annotationAdd BLAST | 114 | |
Domaini | 307 – 407 | SRCR 3PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 417 – 525 | SRCR 4PROSITE-ProRule annotationAdd BLAST | 109 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 529 – 732 | Lysyl-oxidase likeAdd BLAST | 204 |
Sequence similaritiesi
Belongs to the lysyl oxidase family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QSX8, Eukaryota |
GeneTreei | ENSGT00940000158157 |
InParanoidi | P58215 |
OMAi | GVRCTGS |
OrthoDBi | 815466at2759 |
PhylomeDBi | P58215 |
TreeFami | TF326061 |
Family and domain databases
Gene3Di | 3.10.250.10, 4 hits |
InterProi | View protein in InterPro IPR001695, Lysyl_oxidase IPR019828, Lysyl_oxidase_CS IPR001190, SRCR IPR017448, SRCR-like_dom IPR036772, SRCR-like_dom_sf |
Pfami | View protein in Pfam PF01186, Lysyl_oxidase, 1 hit PF00530, SRCR, 4 hits |
PRINTSi | PR00074, LYSYLOXIDASE PR00258, SPERACTRCPTR |
SMARTi | View protein in SMART SM00202, SR, 4 hits |
SUPFAMi | SSF56487, SSF56487, 4 hits |
PROSITEi | View protein in PROSITE PS00926, LYSYL_OXIDASE, 1 hit PS00420, SRCR_1, 1 hit PS50287, SRCR_2, 4 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P58215-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP
60 70 80 90 100
RKPYEGRVEI QRAGEWGTIC DDDFTLQAAH ILCRELGFTE ATGWTHSAKY
110 120 130 140 150
GPGTGRIWLD NLSCSGTEQS VTECASRGWG NSDCTHDEDA GVICKDQRLP
160 170 180 190 200
GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR PLPVTEGLVE VRLPDGWSQV
210 220 230 240 250
CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS FGLHGVACVG
260 270 280 290 300
TEAHLSLCSL EFYRANDTAR CPGGGPAVVS CVPGPVYAAS SGQKKQQQSK
310 320 330 340 350
PQGEARVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLHA ASVVCRELGF
360 370 380 390 400
GSAREALSGA RMGQGMGAIH LSEVRCSGQE LSLWKCPHKN ITAEDCSHSQ
410 420 430 440 450
DAGVRCNLPY TGAETRIRLS GGRSQHEGRV EVQIGGPGPL RWGLICGDDW
460 470 480 490 500
GTLEAMVACR QLGLGYANHG LQETWYWDSG NITEVVMSGV RCTGTELSLD
510 520 530 540 550
QCAHHGTHIT CKRTGTRFTA GVICSETASD LLLHSALVQE TAYIEDRPLH
560 570 580 590 600
MLYCAAEENC LASSARSANW PYGHRRLLRF SSQIHNLGRA DFRPKAGRHS
610 620 630 640 650
WVWHECHGHY HSMDIFTHYD ILTPNGTKVA EGHKASFCLE DTECQEDVSK
660 670 680 690 700
RYECANFGEQ GITVGCWDLY RHDIDCQWID ITDVKPGNYI LQVVINPNFE
710 720 730 740 750
VAESDFTNNA MKCNCKYDGH RIWVHNCHIG DAFSEEANRR FERYPGQTSN
QII
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB8ZZT6 | B8ZZT6_HUMAN | Lysyl oxidase homolog | LOXL3 | 471 | Annotation score: | ||
E7END4 | E7END4_HUMAN | Lysyl oxidase homolog | LOXL3 | 697 | Annotation score: | ||
B9A025 | B9A025_HUMAN | Lysyl oxidase homolog | LOXL3 | 586 | Annotation score: | ||
H7C248 | H7C248_HUMAN | Lysyl oxidase homolog 3 | LOXL3 | 180 | Annotation score: | ||
C9J5M1 | C9J5M1_HUMAN | Lysyl oxidase homolog 3 | LOXL3 | 303 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 159 | E → K in AAK91134 (PubMed:11334717).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050011 | 615 | I → F. Corresponds to variant dbSNP:rs17010021EnsemblClinVar. | 1 | |
Natural variantiVAR_077909 | 676 | C → Y Found in patients with Stickler syndrome; sporadic case; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs786204838EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054417 | 1 – 361 | Missing in isoform 2. 1 PublicationAdd BLAST | 361 | |
Alternative sequenceiVSP_054418 | 159 – 303 | Missing in isoform 3. 1 PublicationAdd BLAST | 145 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF282619 mRNA Translation: AAK51671.1 AF311313 mRNA Translation: AAK63205.1 AF284815 mRNA Translation: AAK91134.1 DQ378059 mRNA Translation: ABD23013.1 AC005033 Genomic DNA No translation available. AC005041 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAW99615.1 CH471053 Genomic DNA Translation: EAW99616.1 BC071865 mRNA Translation: AAH71865.1 |
CCDSi | CCDS1953.1 [P58215-1] CCDS74527.1 [P58215-3] |
RefSeqi | NP_001276093.1, NM_001289164.2 [P58215-3] NP_001276094.1, NM_001289165.1 [P58215-2] NP_115992.1, NM_032603.4 [P58215-1] XP_011531436.1, XM_011533134.2 [P58215-1] XP_016860601.1, XM_017005112.1 [P58215-2] |
Genome annotation databases
Ensembli | ENST00000264094; ENSP00000264094; ENSG00000115318 [P58215-1] ENST00000393937; ENSP00000377512; ENSG00000115318 [P58215-3] |
GeneIDi | 84695 |
KEGGi | hsa:84695 |
UCSCi | uc002smp.3, human [P58215-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF282619 mRNA Translation: AAK51671.1 AF311313 mRNA Translation: AAK63205.1 AF284815 mRNA Translation: AAK91134.1 DQ378059 mRNA Translation: ABD23013.1 AC005033 Genomic DNA No translation available. AC005041 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAW99615.1 CH471053 Genomic DNA Translation: EAW99616.1 BC071865 mRNA Translation: AAH71865.1 |
CCDSi | CCDS1953.1 [P58215-1] CCDS74527.1 [P58215-3] |
RefSeqi | NP_001276093.1, NM_001289164.2 [P58215-3] NP_001276094.1, NM_001289165.1 [P58215-2] NP_115992.1, NM_032603.4 [P58215-1] XP_011531436.1, XM_011533134.2 [P58215-1] XP_016860601.1, XM_017005112.1 [P58215-2] |
3D structure databases
SMRi | P58215 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124210, 12 interactors |
IntActi | P58215, 5 interactors |
STRINGi | 9606.ENSP00000264094 |
Chemistry databases
BindingDBi | P58215 |
ChEMBLi | CHEMBL4105989 |
PTM databases
GlyConnecti | 1481, 3 N-Linked glycans (1 site) |
GlyGeni | P58215, 5 sites |
iPTMneti | P58215 |
PhosphoSitePlusi | P58215 |
Genetic variation databases
BioMutai | LOXL3 |
DMDMi | 14916616 |
Proteomic databases
jPOSTi | P58215 |
MassIVEi | P58215 |
PaxDbi | P58215 |
PeptideAtlasi | P58215 |
PRIDEi | P58215 |
ProteomicsDBi | 57056 [P58215-1] 66450 |
Protocols and materials databases
Antibodypediai | 31582, 178 antibodies |
Genome annotation databases
Ensembli | ENST00000264094; ENSP00000264094; ENSG00000115318 [P58215-1] ENST00000393937; ENSP00000377512; ENSG00000115318 [P58215-3] |
GeneIDi | 84695 |
KEGGi | hsa:84695 |
UCSCi | uc002smp.3, human [P58215-1] |
Organism-specific databases
CTDi | 84695 |
DisGeNETi | 84695 |
GeneCardsi | LOXL3 |
HGNCi | HGNC:13869, LOXL3 |
HPAi | ENSG00000115318, Low tissue specificity |
MalaCardsi | LOXL3 |
MIMi | 607163, gene |
neXtProti | NX_P58215 |
OpenTargetsi | ENSG00000115318 |
Orphaneti | 250984, Autosomal recessive Stickler syndrome |
PharmGKBi | PA30430 |
VEuPathDBi | HostDB:ENSG00000115318.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSX8, Eukaryota |
GeneTreei | ENSGT00940000158157 |
InParanoidi | P58215 |
OMAi | GVRCTGS |
OrthoDBi | 815466at2759 |
PhylomeDBi | P58215 |
TreeFami | TF326061 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000115318-MONOMER |
BRENDAi | 1.4.3.13, 2681 |
PathwayCommonsi | P58215 |
Reactomei | R-HSA-1566948, Elastic fibre formation R-HSA-2243919, Crosslinking of collagen fibrils |
Miscellaneous databases
BioGRID-ORCSi | 84695, 4 hits in 991 CRISPR screens |
ChiTaRSi | LOXL3, human |
GeneWikii | LOXL3 |
GenomeRNAii | 84695 |
Pharosi | P58215, Tbio |
PROi | PR:P58215 |
RNActi | P58215, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115318, Expressed in tibia and 180 other tissues |
ExpressionAtlasi | P58215, baseline and differential |
Genevisiblei | P58215, HS |
Family and domain databases
Gene3Di | 3.10.250.10, 4 hits |
InterProi | View protein in InterPro IPR001695, Lysyl_oxidase IPR019828, Lysyl_oxidase_CS IPR001190, SRCR IPR017448, SRCR-like_dom IPR036772, SRCR-like_dom_sf |
Pfami | View protein in Pfam PF01186, Lysyl_oxidase, 1 hit PF00530, SRCR, 4 hits |
PRINTSi | PR00074, LYSYLOXIDASE PR00258, SPERACTRCPTR |
SMARTi | View protein in SMART SM00202, SR, 4 hits |
SUPFAMi | SSF56487, SSF56487, 4 hits |
PROSITEi | View protein in PROSITE PS00926, LYSYL_OXIDASE, 1 hit PS00420, SRCR_1, 1 hit PS50287, SRCR_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LOXL3_HUMAN | |
Accessioni | P58215Primary (citable) accession number: P58215 Secondary accession number(s): D6W5J1 Q96RS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2001 |
Last sequence update: | July 11, 2001 | |
Last modified: | April 7, 2021 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families