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UniProtKB - P58215 (LOXL3_HUMAN)

Entry version 173 (07 Apr 2021)
Sequence version 1 (11 Jul 2001)
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Protein

Lysyl oxidase homolog 3

Gene

LOXL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600).By similarity2 Publications
Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII (PubMed:17018530).1 Publication
Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV (PubMed:17018530).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.058 sec(-1) with STAT3 acetylated at 'Lys-685' (for deacetylation activity). kcat is 0.022 sec(-1) with STAT3 acetylated at 'Lys-685' (for lysine 6-oxidase activity).1 Publication
  1. KM=6.72 µM for STAT3 acetylated at 'Lys-685' (for deacetylation activity)1 Publication
  2. KM=1.59 µM for STAT3 acetylated at 'Lys-685' (for lysine 6-oxidase activity)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi607CopperSequence analysis1
    Metal bindingi609CopperSequence analysis1
    Metal bindingi611CopperSequence analysis1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processInflammatory response
    LigandCopper, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:ENSG00000115318-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		1.4.3.13, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		P58215

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-1566948, Elastic fibre formation
    R-HSA-2243919, Crosslinking of collagen fibrils

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Lysyl oxidase homolog 3Curated (EC:1.4.3.-1 Publication, EC:1.4.3.131 Publication)
    Alternative name(s):
    Lysyl oxidase-like protein 31 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:LOXL31 PublicationImported
    Synonyms:LOXL1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:13869, LOXL3

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		607163, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P58215

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000115318.11

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Defects in LOXL3 are found in a family with an autosomal recessive form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence and sensorineural deafness (PubMed:25663169). Pierre Robin sequence includes an opening in the roof of the mouth (a cleft palate) (PubMed:25663169). The degree of hearing loss varies among affected individuals and may become more severe over time (PubMed:25663169). Syndrome expressivity is variable (PubMed:25663169). Ocular disorders include non-progressive myopia with associated chorioretinal degeneration (PubMed:25663169). Defects in LOXL3 are found in another family with early-onset high myopia (PubMed:26957899). The disease may be caused by variants affecting the gene represented in this entry (PubMed:25663169, PubMed:26957899).2 Publications

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi83C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-214; A-345 and A-459. 1 Publication1
    Mutagenesisi214C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-83; A-345 and A-459. 1 Publication1
    Mutagenesisi345C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-83; A-214 and A-459. 1 Publication1
    Mutagenesisi376C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-446 and A-492. 1 Publication1
    Mutagenesisi446C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-376 and A-492. 1 Publication1
    Mutagenesisi459C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-83; A-214 and A-345. 1 Publication1
    Mutagenesisi492C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-376 and A-446. 1 Publication1
    Mutagenesisi607 – 609HGH → QGQ: Impaired ability to mediate deacetylation of STAT3. 1 Publication3

    Keywords - Diseasei

    Deafness, Stickler syndrome

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		84695

    MalaCards human disease database

    More...    MalaCardsi    		LOXL3

    Open Targets

    More...    OpenTargetsi    		ENSG00000115318

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...    Orphaneti    		250984, Autosomal recessive Stickler syndrome

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA30430

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P58215, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL4105989

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		LOXL3

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		14916616

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001853326 – 753Lysyl oxidase homolog 3Add BLAST728

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi70 ↔ 134PROSITE-ProRule annotation
    Disulfide bondi83 ↔ 144PROSITE-ProRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi114 ↔ 124PROSITE-ProRule annotation
    Disulfide bondi201 ↔ 271PROSITE-ProRule annotation
    Disulfide bondi214 ↔ 281PROSITE-ProRule annotation
    Disulfide bondi248 ↔ 258PROSITE-ProRule annotation
    Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi332 ↔ 396PROSITE-ProRule annotation
    Disulfide bondi345 ↔ 406PROSITE-ProRule annotation
    Disulfide bondi376 ↔ 386PROSITE-ProRule annotation
    Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi446 ↔ 511PROSITE-ProRule annotation
    Disulfide bondi459 ↔ 524PROSITE-ProRule annotation
    Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi492 ↔ 502PROSITE-ProRule annotation
    Disulfide bondi554 ↔ 560PROSITE-ProRule annotation
    Disulfide bondi606 ↔ 654PROSITE-ProRule annotation
    Glycosylationi625N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki634 ↔ 670Lysine tyrosylquinone (Lys-Tyr)By similarity
    Disulfide bondi638 ↔ 644PROSITE-ProRule annotation
    Disulfide bondi666 ↔ 676PROSITE-ProRule annotation
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6702',4',5'-topaquinoneBy similarity1
    Disulfide bondi713 ↔ 727PROSITE-ProRule annotation

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, LTQ, TPQ

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P58215

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P58215

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P58215

    PeptideAtlas

    More...    PeptideAtlasi    		P58215

    PRoteomics IDEntifications database

    More...    PRIDEi    		P58215

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		57056 [P58215-1]
    66450

    PTM databases

    GlyConnect protein glycosylation platform

    More...    GlyConnecti    		1481, 3 N-Linked glycans (1 site)

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...    GlyGeni    		P58215, 5 sites

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P58215

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P58215

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Isoform 1: Predominantly detected in the heart, placenta, lung, and small intestine (PubMed:17018530). Isoform 2: Highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung (PubMed:17018530). In eye, present in all layers of corneas as well as in the limbus and conjunctiva (at protein level) (PubMed:26218558).2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000115318, Expressed in tibia and 180 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P58215, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P58215, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000115318, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with STAT3 (PubMed:28065600).

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		124210, 12 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P58215, 5 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000264094

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P58215

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P58215, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P58215

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 145SRCR 1PROSITE-ProRule annotationAdd BLAST102
    Domaini169 – 282SRCR 2PROSITE-ProRule annotationAdd BLAST114
    Domaini307 – 407SRCR 3PROSITE-ProRule annotationAdd BLAST101
    Domaini417 – 525SRCR 4PROSITE-ProRule annotationAdd BLAST109

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni529 – 732Lysyl-oxidase likeAdd BLAST204

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the lysyl oxidase family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		ENOG502QSX8, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000158157

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P58215

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		GVRCTGS

    Database of Orthologous Groups

    More...    OrthoDBi    		815466at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P58215

    TreeFam database of animal gene trees

    More...    TreeFami    		TF326061

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.10.250.10, 4 hits

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR001695, Lysyl_oxidase
    IPR019828, Lysyl_oxidase_CS
    IPR001190, SRCR
    IPR017448, SRCR-like_dom
    IPR036772, SRCR-like_dom_sf

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF01186, Lysyl_oxidase, 1 hit
    PF00530, SRCR, 4 hits

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00074, LYSYLOXIDASE
    PR00258, SPERACTRCPTR

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00202, SR, 4 hits

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF56487, SSF56487, 4 hits

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00926, LYSYL_OXIDASE, 1 hit
    PS00420, SRCR_1, 1 hit
    PS50287, SRCR_2, 4 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P58215-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP 
            60         70         80         90        100
    RKPYEGRVEI QRAGEWGTIC DDDFTLQAAH ILCRELGFTE ATGWTHSAKY 
           110        120        130        140        150
    GPGTGRIWLD NLSCSGTEQS VTECASRGWG NSDCTHDEDA GVICKDQRLP 
           160        170        180        190        200
    GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR PLPVTEGLVE VRLPDGWSQV 
           210        220        230        240        250
    CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS FGLHGVACVG 
           260        270        280        290        300
    TEAHLSLCSL EFYRANDTAR CPGGGPAVVS CVPGPVYAAS SGQKKQQQSK 
           310        320        330        340        350
    PQGEARVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLHA ASVVCRELGF 
           360        370        380        390        400
    GSAREALSGA RMGQGMGAIH LSEVRCSGQE LSLWKCPHKN ITAEDCSHSQ 
           410        420        430        440        450
    DAGVRCNLPY TGAETRIRLS GGRSQHEGRV EVQIGGPGPL RWGLICGDDW 
           460        470        480        490        500
    GTLEAMVACR QLGLGYANHG LQETWYWDSG NITEVVMSGV RCTGTELSLD 
           510        520        530        540        550
    QCAHHGTHIT CKRTGTRFTA GVICSETASD LLLHSALVQE TAYIEDRPLH 
           560        570        580        590        600
    MLYCAAEENC LASSARSANW PYGHRRLLRF SSQIHNLGRA DFRPKAGRHS 
           610        620        630        640        650
    WVWHECHGHY HSMDIFTHYD ILTPNGTKVA EGHKASFCLE DTECQEDVSK 
           660        670        680        690        700
    RYECANFGEQ GITVGCWDLY RHDIDCQWID ITDVKPGNYI LQVVINPNFE 
           710        720        730        740        750
    VAESDFTNNA MKCNCKYDGH RIWVHNCHIG DAFSEEANRR FERYPGQTSN 

    QII
    Length:753
    Mass (Da):83,166
    Last modified:July 11, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i582C46DA25E05A69
    GO
    Isoform 2 (identifier: P58215-2) [UniParc]FASTAAdd to basket
    Also known as: LOXL3-sv11 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1-361: Missing.

    Note: Misses three SRCR domains.Curated
    Show »
    Length:392
    Mass (Da):44,049
    Checksum:iEF83ED2AB3CE9EC0
    GO
    Isoform 3 (identifier: P58215-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         159-303: Missing.

    Show »
    Length:608
    Mass (Da):67,445
    Checksum:iB33B22A417B184DD
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    B8ZZT6B8ZZT6_HUMAN
    Lysyl oxidase homolog
    LOXL3
    		471Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7END4E7END4_HUMAN
    Lysyl oxidase homolog
    LOXL3
    		697Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B9A025B9A025_HUMAN
    Lysyl oxidase homolog
    LOXL3
    		586Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C248H7C248_HUMAN
    Lysyl oxidase homolog 3
    LOXL3
    		180Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9J5M1C9J5M1_HUMAN
    Lysyl oxidase homolog 3
    LOXL3
    		303Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159E → K in AAK91134 (PubMed:11334717).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050011615I → F. Corresponds to variant dbSNP:rs17010021EnsemblClinVar.1
    Natural variantiVAR_077909676C → Y Found in patients with Stickler syndrome; sporadic case; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs786204838EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0544171 – 361Missing in isoform 2. 1 PublicationAdd BLAST361
    Alternative sequenceiVSP_054418159 – 303Missing in isoform 3. 1 PublicationAdd BLAST145

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF282619 mRNA Translation: AAK51671.1
    AF311313 mRNA Translation: AAK63205.1
    AF284815 mRNA Translation: AAK91134.1
    DQ378059 mRNA Translation: ABD23013.1
    AC005033 Genomic DNA No translation available.
    AC005041 Genomic DNA No translation available.
    CH471053 Genomic DNA Translation: EAW99615.1
    CH471053 Genomic DNA Translation: EAW99616.1
    BC071865 mRNA Translation: AAH71865.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS1953.1 [P58215-1]
    CCDS74527.1 [P58215-3]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001276093.1, NM_001289164.2 [P58215-3]
    NP_001276094.1, NM_001289165.1 [P58215-2]
    NP_115992.1, NM_032603.4 [P58215-1]
    XP_011531436.1, XM_011533134.2 [P58215-1]
    XP_016860601.1, XM_017005112.1 [P58215-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000264094; ENSP00000264094; ENSG00000115318 [P58215-1]
    ENST00000393937; ENSP00000377512; ENSG00000115318 [P58215-3]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		84695

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:84695

    UCSC genome browser

    More...    UCSCi    		uc002smp.3, human [P58215-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF282619 mRNA Translation: AAK51671.1
    AF311313 mRNA Translation: AAK63205.1
    AF284815 mRNA Translation: AAK91134.1
    DQ378059 mRNA Translation: ABD23013.1
    AC005033 Genomic DNA No translation available.
    AC005041 Genomic DNA No translation available.
    CH471053 Genomic DNA Translation: EAW99615.1
    CH471053 Genomic DNA Translation: EAW99616.1
    BC071865 mRNA Translation: AAH71865.1
    CCDSiCCDS1953.1 [P58215-1]
    CCDS74527.1 [P58215-3]
    RefSeqiNP_001276093.1, NM_001289164.2 [P58215-3]
    NP_001276094.1, NM_001289165.1 [P58215-2]
    NP_115992.1, NM_032603.4 [P58215-1]
    XP_011531436.1, XM_011533134.2 [P58215-1]
    XP_016860601.1, XM_017005112.1 [P58215-2]

    3D structure databases

    SMRiP58215
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi124210, 12 interactors
    IntActiP58215, 5 interactors
    STRINGi9606.ENSP00000264094

    Chemistry databases

    BindingDBiP58215
    ChEMBLiCHEMBL4105989

    PTM databases

    GlyConnecti1481, 3 N-Linked glycans (1 site)
    GlyGeniP58215, 5 sites
    iPTMnetiP58215
    PhosphoSitePlusiP58215

    Genetic variation databases

    BioMutaiLOXL3
    DMDMi14916616

    Proteomic databases

    jPOSTiP58215
    MassIVEiP58215
    PaxDbiP58215
    PeptideAtlasiP58215
    PRIDEiP58215
    ProteomicsDBi57056 [P58215-1]
    66450

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		31582, 178 antibodies

    Genome annotation databases

    EnsembliENST00000264094; ENSP00000264094; ENSG00000115318 [P58215-1]
    ENST00000393937; ENSP00000377512; ENSG00000115318 [P58215-3]
    GeneIDi84695
    KEGGihsa:84695
    UCSCiuc002smp.3, human [P58215-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		84695
    DisGeNETi84695

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		LOXL3
    HGNCiHGNC:13869, LOXL3
    HPAiENSG00000115318, Low tissue specificity
    MalaCardsiLOXL3
    MIMi607163, gene
    neXtProtiNX_P58215
    OpenTargetsiENSG00000115318
    Orphaneti250984, Autosomal recessive Stickler syndrome
    PharmGKBiPA30430
    VEuPathDBiHostDB:ENSG00000115318.11

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiENOG502QSX8, Eukaryota
    GeneTreeiENSGT00940000158157
    InParanoidiP58215
    OMAiGVRCTGS
    OrthoDBi815466at2759
    PhylomeDBiP58215
    TreeFamiTF326061

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000115318-MONOMER
    BRENDAi1.4.3.13, 2681
    PathwayCommonsiP58215
    ReactomeiR-HSA-1566948, Elastic fibre formation
    R-HSA-2243919, Crosslinking of collagen fibrils

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		84695, 4 hits in 991 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		LOXL3, human

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		LOXL3

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		84695
    PharosiP58215, Tbio

    Protein Ontology

    More...    PROi    		PR:P58215
    RNActiP58215, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000115318, Expressed in tibia and 180 other tissues
    ExpressionAtlasiP58215, baseline and differential
    GenevisibleiP58215, HS

    Family and domain databases

    Gene3Di3.10.250.10, 4 hits
    InterProiView protein in InterPro
    IPR001695, Lysyl_oxidase
    IPR019828, Lysyl_oxidase_CS
    IPR001190, SRCR
    IPR017448, SRCR-like_dom
    IPR036772, SRCR-like_dom_sf
    PfamiView protein in Pfam
    PF01186, Lysyl_oxidase, 1 hit
    PF00530, SRCR, 4 hits
    PRINTSiPR00074, LYSYLOXIDASE
    PR00258, SPERACTRCPTR
    SMARTiView protein in SMART
    SM00202, SR, 4 hits
    SUPFAMiSSF56487, SSF56487, 4 hits
    PROSITEiView protein in PROSITE
    PS00926, LYSYL_OXIDASE, 1 hit
    PS00420, SRCR_1, 1 hit
    PS50287, SRCR_2, 4 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLOXL3_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58215
    Secondary accession number(s): D6W5J1
    , Q2EHP2, Q6IPL7, Q96RS1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: July 11, 2001
    Last modified: April 7, 2021
    This is version 173 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with genetic variants
      List of human entries with genetic variants
    3. Human variants curated from literature reports
      Index of human variants curated from literature reports
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families
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