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UniProtKB - P58215 (LOXL3_HUMAN)

Entry version 175 (29 Sep 2021)
Sequence version 1 (11 Jul 2001)
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Protein

Lysyl oxidase homolog 3

Gene

LOXL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600).

Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530).

Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity).

Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600).

Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).

Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600).

By similarity2 Publications

Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII (PubMed:17018530).

1 Publication

Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV (PubMed:17018530).

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.058 sec(-1) with STAT3 acetylated at 'Lys-685' (for deacetylation activity). kcat is 0.022 sec(-1) with STAT3 acetylated at 'Lys-685' (for lysine 6-oxidase activity).1 Publication
  1. KM=6.72 µM for STAT3 acetylated at 'Lys-685' (for deacetylation activity)1 Publication
  2. KM=1.59 µM for STAT3 acetylated at 'Lys-685' (for lysine 6-oxidase activity)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi607CopperSequence analysis1
Metal bindingi609CopperSequence analysis1
Metal bindingi611CopperSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processInflammatory response
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:ENSG00000115318-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.4.3.13, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P58215

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1566948, Elastic fibre formation
R-HSA-2243919, Crosslinking of collagen fibrils

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysyl oxidase homolog 3Curated (EC:1.4.3.-1 Publication, EC:1.4.3.131 Publication)
Alternative name(s):
Lysyl oxidase-like protein 31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOXL31 PublicationImported
Synonyms:LOXL1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13869, LOXL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607163, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P58215

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000115318

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in LOXL3 are found in a family with an autosomal recessive form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence and sensorineural deafness (PubMed:25663169). Pierre Robin sequence includes an opening in the roof of the mouth (a cleft palate) (PubMed:25663169). The degree of hearing loss varies among affected individuals and may become more severe over time (PubMed:25663169). Syndrome expressivity is variable (PubMed:25663169). Ocular disorders include non-progressive myopia with associated chorioretinal degeneration (PubMed:25663169). Defects in LOXL3 are found in another family with early-onset high myopia (PubMed:26957899). The disease may be caused by variants affecting the gene represented in this entry (PubMed:25663169, PubMed:26957899).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi83C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-214; A-345 and A-459. 1 Publication1
Mutagenesisi214C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-83; A-345 and A-459. 1 Publication1
Mutagenesisi345C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-83; A-214 and A-459. 1 Publication1
Mutagenesisi376C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-446 and A-492. 1 Publication1
Mutagenesisi446C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-376 and A-492. 1 Publication1
Mutagenesisi459C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-83; A-214 and A-345. 1 Publication1
Mutagenesisi492C → A: Impaired ability to mediate deacetylation of STAT3; when associated with A-376 and A-446. 1 Publication1
Mutagenesisi607 – 609HGH → QGQ: Impaired ability to mediate deacetylation of STAT3. 1 Publication3

Keywords - Diseasei

Deafness, Stickler syndrome

Organism-specific databases

DisGeNET

More...DisGeNETi		84695

MalaCards human disease database

More...MalaCardsi		LOXL3

Open Targets

More...OpenTargetsi		ENSG00000115318

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		250984, Autosomal recessive Stickler syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30430

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P58215, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105989

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LOXL3

Domain mapping of disease mutations (DMDM)

More...DMDMi		14916616

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001853326 – 753Lysyl oxidase homolog 3Add BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi70 ↔ 134PROSITE-ProRule annotation
Disulfide bondi83 ↔ 144PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 124PROSITE-ProRule annotation
Disulfide bondi201 ↔ 271PROSITE-ProRule annotation
Disulfide bondi214 ↔ 281PROSITE-ProRule annotation
Disulfide bondi248 ↔ 258PROSITE-ProRule annotation
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi332 ↔ 396PROSITE-ProRule annotation
Disulfide bondi345 ↔ 406PROSITE-ProRule annotation
Disulfide bondi376 ↔ 386PROSITE-ProRule annotation
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi446 ↔ 511PROSITE-ProRule annotation
Disulfide bondi459 ↔ 524PROSITE-ProRule annotation
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi492 ↔ 502PROSITE-ProRule annotation
Disulfide bondi554 ↔ 560PROSITE-ProRule annotation
Disulfide bondi606 ↔ 654PROSITE-ProRule annotation
Glycosylationi625N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki634 ↔ 670Lysine tyrosylquinone (Lys-Tyr)By similarity
Disulfide bondi638 ↔ 644PROSITE-ProRule annotation
Disulfide bondi666 ↔ 676PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6702',4',5'-topaquinoneBy similarity1
Disulfide bondi713 ↔ 727PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, LTQ, TPQ

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P58215

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P58215

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P58215

PeptideAtlas

More...PeptideAtlasi		P58215

PRoteomics IDEntifications database

More...PRIDEi		P58215

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57056 [P58215-1]
66450

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1481, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P58215, 5 sites, 3 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P58215

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P58215

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1: Predominantly detected in the heart, placenta, lung, and small intestine (PubMed:17018530). Isoform 2: Highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung (PubMed:17018530). In eye, present in all layers of corneas as well as in the limbus and conjunctiva (at protein level) (PubMed:26218558).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000115318, Expressed in tibia and 181 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P58215, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P58215, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000115318, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STAT3 (PubMed:28065600).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124210, 12 interactors

Protein interaction database and analysis system

More...IntActi		P58215, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000264094

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P58215

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P58215, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P58215

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 145SRCR 1PROSITE-ProRule annotationAdd BLAST102
Domaini169 – 282SRCR 2PROSITE-ProRule annotationAdd BLAST114
Domaini307 – 407SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini417 – 525SRCR 4PROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni290 – 315DisorderedSequence analysisAdd BLAST26
Regioni529 – 732Lysyl-oxidase likeAdd BLAST204

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lysyl oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSX8, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158157

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P58215

Identification of Orthologs from Complete Genome Data

More...OMAi		GVRCTGS

Database of Orthologous Groups

More...OrthoDBi		815466at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P58215

TreeFam database of animal gene trees

More...TreeFami		TF326061

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.250.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001695, Lysyl_oxidase
IPR019828, Lysyl_oxidase_CS
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01186, Lysyl_oxidase, 1 hit
PF00530, SRCR, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00074, LYSYLOXIDASE
PR00258, SPERACTRCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00202, SR, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56487, SSF56487, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00926, LYSYL_OXIDASE, 1 hit
PS00420, SRCR_1, 1 hit
PS50287, SRCR_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P58215-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP 
        60         70         80         90        100
RKPYEGRVEI QRAGEWGTIC DDDFTLQAAH ILCRELGFTE ATGWTHSAKY 
       110        120        130        140        150
GPGTGRIWLD NLSCSGTEQS VTECASRGWG NSDCTHDEDA GVICKDQRLP 
       160        170        180        190        200
GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR PLPVTEGLVE VRLPDGWSQV 
       210        220        230        240        250
CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS FGLHGVACVG 
       260        270        280        290        300
TEAHLSLCSL EFYRANDTAR CPGGGPAVVS CVPGPVYAAS SGQKKQQQSK 
       310        320        330        340        350
PQGEARVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLHA ASVVCRELGF 
       360        370        380        390        400
GSAREALSGA RMGQGMGAIH LSEVRCSGQE LSLWKCPHKN ITAEDCSHSQ 
       410        420        430        440        450
DAGVRCNLPY TGAETRIRLS GGRSQHEGRV EVQIGGPGPL RWGLICGDDW 
       460        470        480        490        500
GTLEAMVACR QLGLGYANHG LQETWYWDSG NITEVVMSGV RCTGTELSLD 
       510        520        530        540        550
QCAHHGTHIT CKRTGTRFTA GVICSETASD LLLHSALVQE TAYIEDRPLH 
       560        570        580        590        600
MLYCAAEENC LASSARSANW PYGHRRLLRF SSQIHNLGRA DFRPKAGRHS 
       610        620        630        640        650
WVWHECHGHY HSMDIFTHYD ILTPNGTKVA EGHKASFCLE DTECQEDVSK 
       660        670        680        690        700
RYECANFGEQ GITVGCWDLY RHDIDCQWID ITDVKPGNYI LQVVINPNFE 
       710        720        730        740        750
VAESDFTNNA MKCNCKYDGH RIWVHNCHIG DAFSEEANRR FERYPGQTSN 

QII
Length:753
Mass (Da):83,166
Last modified:July 11, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i582C46DA25E05A69
GO
Isoform 2 (identifier: P58215-2) [UniParc]FASTAAdd to basket
Also known as: LOXL3-sv11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-361: Missing.

Note: Misses three SRCR domains.Curated
Show »
Length:392
Mass (Da):44,049
Checksum:iEF83ED2AB3CE9EC0
GO
Isoform 3 (identifier: P58215-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-303: Missing.

Show »
Length:608
Mass (Da):67,445
Checksum:iB33B22A417B184DD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZT6B8ZZT6_HUMAN
Lysyl oxidase homolog
LOXL3
471Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7END4E7END4_HUMAN
Lysyl oxidase homolog
LOXL3
697Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9A025B9A025_HUMAN
Lysyl oxidase homolog
LOXL3
586Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C248H7C248_HUMAN
Lysyl oxidase homolog 3
LOXL3
180Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5M1C9J5M1_HUMAN
Lysyl oxidase homolog 3
LOXL3
303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159E → K in AAK91134 (PubMed:11334717).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050011615I → F. Corresponds to variant dbSNP:rs17010021EnsemblClinVar.1
Natural variantiVAR_077909676C → Y Found in patients with Stickler syndrome; sporadic case; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs786204838EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0544171 – 361Missing in isoform 2. 1 PublicationAdd BLAST361
Alternative sequenceiVSP_054418159 – 303Missing in isoform 3. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF282619 mRNA Translation: AAK51671.1
AF311313 mRNA Translation: AAK63205.1
AF284815 mRNA Translation: AAK91134.1
DQ378059 mRNA Translation: ABD23013.1
AC005033 Genomic DNA No translation available.
AC005041 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99615.1
CH471053 Genomic DNA Translation: EAW99616.1
BC071865 mRNA Translation: AAH71865.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1953.1 [P58215-1]
CCDS74527.1 [P58215-3]

NCBI Reference Sequences

More...RefSeqi		NP_001276093.1, NM_001289164.2 [P58215-3]
NP_001276094.1, NM_001289165.1 [P58215-2]
NP_115992.1, NM_032603.4 [P58215-1]
XP_011531436.1, XM_011533134.2 [P58215-1]
XP_016860601.1, XM_017005112.1 [P58215-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264094; ENSP00000264094; ENSG00000115318 [P58215-1]
ENST00000393937; ENSP00000377512; ENSG00000115318 [P58215-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84695

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84695

UCSC genome browser

More...UCSCi		uc002smp.3, human [P58215-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282619 mRNA Translation: AAK51671.1
AF311313 mRNA Translation: AAK63205.1
AF284815 mRNA Translation: AAK91134.1
DQ378059 mRNA Translation: ABD23013.1
AC005033 Genomic DNA No translation available.
AC005041 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99615.1
CH471053 Genomic DNA Translation: EAW99616.1
BC071865 mRNA Translation: AAH71865.1
CCDSiCCDS1953.1 [P58215-1]
CCDS74527.1 [P58215-3]
RefSeqiNP_001276093.1, NM_001289164.2 [P58215-3]
NP_001276094.1, NM_001289165.1 [P58215-2]
NP_115992.1, NM_032603.4 [P58215-1]
XP_011531436.1, XM_011533134.2 [P58215-1]
XP_016860601.1, XM_017005112.1 [P58215-2]

3D structure databases

SMRiP58215
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124210, 12 interactors
IntActiP58215, 5 interactors
STRINGi9606.ENSP00000264094

Chemistry databases

BindingDBiP58215
ChEMBLiCHEMBL4105989

PTM databases

GlyConnecti1481, 3 N-Linked glycans (1 site)
GlyGeniP58215, 5 sites, 3 N-linked glycans (1 site)
iPTMnetiP58215
PhosphoSitePlusiP58215

Genetic variation databases

BioMutaiLOXL3
DMDMi14916616

Proteomic databases

jPOSTiP58215
MassIVEiP58215
PaxDbiP58215
PeptideAtlasiP58215
PRIDEiP58215
ProteomicsDBi57056 [P58215-1]
66450

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31582, 184 antibodies

The DNASU plasmid repository

More...DNASUi		84695

Genome annotation databases

EnsembliENST00000264094; ENSP00000264094; ENSG00000115318 [P58215-1]
ENST00000393937; ENSP00000377512; ENSG00000115318 [P58215-3]
GeneIDi84695
KEGGihsa:84695
UCSCiuc002smp.3, human [P58215-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84695
DisGeNETi84695

GeneCards: human genes, protein and diseases

More...GeneCardsi		LOXL3
HGNCiHGNC:13869, LOXL3
HPAiENSG00000115318, Low tissue specificity
MalaCardsiLOXL3
MIMi607163, gene
neXtProtiNX_P58215
OpenTargetsiENSG00000115318
Orphaneti250984, Autosomal recessive Stickler syndrome
PharmGKBiPA30430
VEuPathDBiHostDB:ENSG00000115318

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSX8, Eukaryota
GeneTreeiENSGT00940000158157
InParanoidiP58215
OMAiGVRCTGS
OrthoDBi815466at2759
PhylomeDBiP58215
TreeFamiTF326061

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000115318-MONOMER
BRENDAi1.4.3.13, 2681
PathwayCommonsiP58215
ReactomeiR-HSA-1566948, Elastic fibre formation
R-HSA-2243919, Crosslinking of collagen fibrils

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84695, 5 hits in 1013 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LOXL3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LOXL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84695
PharosiP58215, Tbio

Protein Ontology

More...PROi		PR:P58215
RNActiP58215, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000115318, Expressed in tibia and 181 other tissues
ExpressionAtlasiP58215, baseline and differential
GenevisibleiP58215, HS

Family and domain databases

Gene3Di3.10.250.10, 4 hits
InterProiView protein in InterPro
IPR001695, Lysyl_oxidase
IPR019828, Lysyl_oxidase_CS
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf
PfamiView protein in Pfam
PF01186, Lysyl_oxidase, 1 hit
PF00530, SRCR, 4 hits
PRINTSiPR00074, LYSYLOXIDASE
PR00258, SPERACTRCPTR
SMARTiView protein in SMART
SM00202, SR, 4 hits
SUPFAMiSSF56487, SSF56487, 4 hits
PROSITEiView protein in PROSITE
PS00926, LYSYL_OXIDASE, 1 hit
PS00420, SRCR_1, 1 hit
PS50287, SRCR_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLOXL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P58215
Secondary accession number(s): D6W5J1
, Q2EHP2, Q6IPL7, Q96RS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: July 11, 2001
Last modified: September 29, 2021
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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