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Protein

Phospholipid scramblase 4

Gene

Plscr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

Cofactori

Ca2+By similarity, Mg2+By similarity

GO - Molecular functioni

  • CD4 receptor binding Source: MGI
  • enzyme binding Source: MGI
  • phospholipid scramblase activity Source: GO_Central

GO - Biological processi

  • cellular response to lipopolysaccharide Source: UniProtKB
  • phospholipid scrambling Source: GO_Central

Keywordsi

LigandCalcium

Enzyme and pathway databases

BRENDAi3.6.99.B1 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid scramblase 4
Short name:
PL scramblase 4
Alternative name(s):
Ca(2+)-dependent phospholipid scramblase 4
Gene namesi
Name:Plscr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2143267 Plscr4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 299CytoplasmicBy similarityAdd BLAST299
Transmembranei300 – 316HelicalSequence analysisAdd BLAST17
Topological domaini317 – 326ExtracellularBy similarity10

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007931 – 326Phospholipid scramblase 4Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79Phosphotyrosine; by ABLBy similarity1
Modified residuei84Phosphotyrosine; by ABLBy similarity1
Lipidationi193S-palmitoyl cysteineBy similarity1
Lipidationi194S-palmitoyl cysteineBy similarity1
Lipidationi195S-palmitoyl cysteineBy similarity1
Lipidationi197S-palmitoyl cysteineBy similarity1
Lipidationi198S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP58196
PaxDbiP58196
PeptideAtlasiP58196
PRIDEiP58196

PTM databases

PhosphoSitePlusiP58196
SwissPalmiP58196

Expressioni

Gene expression databases

BgeeiENSMUSG00000032377 Expressed in 162 organ(s), highest expression level in brain blood vessel
CleanExiMM_PLSCR4
GenevisibleiP58196 MM

Interactioni

Subunit structurei

Interacts with PDCD6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034941

Structurei

3D structure databases

ProteinModelPortaliP58196
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 94Proline-rich domain (PRD)By similarityAdd BLAST94

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi18 – 25SH3-binding 1Sequence analysis8
Motifi30 – 33PPxY motifSequence analysis4
Motifi41 – 49SH3-binding 2Sequence analysis9
Motifi94 – 102SH3-binding 3Sequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi191 – 200Cys-rich10

Domaini

The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.By similarity

Sequence similaritiesi

Belongs to the phospholipid scramblase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0621 Eukaryota
ENOG410XSYS LUCA
GeneTreeiENSGT00390000002884
HOGENOMiHOG000237356
HOVERGENiHBG019157
InParanoidiP58196
OMAiDQMVYIV
OrthoDBiEOG091G0CUL
PhylomeDBiP58196
TreeFamiTF314939

Family and domain databases

InterProiView protein in InterPro
IPR005552 Scramblase
PANTHERiPTHR23248 PTHR23248, 1 hit
PfamiView protein in Pfam
PF03803 Scramblase, 1 hit

Sequencei

Sequence statusi: Complete.

P58196-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGLVPTAPE QPTEEMENQI KSPTAVPDAP PDYNSHFAPG PAGPVASPSA
60 70 80 90 100
GLPMGYYIPQ QPGAIPLYHP TGGTHPIQYQ PGKYPVTNQP APIMWMAGPA
110 120 130 140 150
PVPNCPPGLE YLAQLDNIHV LQHVEPLELM TRFETNNRYD IKNNIDQMVY
160 170 180 190 200
IVTEDTDDFT RNAYRNLRPF VLRVTDCLGR EIMTMQRPFR CTCCCFCCPC
210 220 230 240 250
ARQELEVQCP PGVTIGFVAE HWNLCRASYS IQNEKKESMM RVRGPCATYG
260 270 280 290 300
CGSDSVFEIN SLDGVSNIGS IIRKWNGFLS TMVNADHFEI RFPLALDVKM
310 320
KAMIFGSCFL IDFMYFERPP PRRMSR
Length:326
Mass (Da):36,579
Last modified:July 19, 2005 - v2
Checksum:i4798174B69DD7555
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035919 mRNA Translation: BAC29242.1
AK082330 mRNA Translation: BAC38468.1
AK141580 mRNA Translation: BAE24748.1
AK165919 mRNA Translation: BAE38460.1
BC052067 mRNA Translation: AAH52067.1
CCDSiCCDS23407.1
RefSeqiNP_848826.1, NM_178711.3
UniGeneiMm.55289

Genome annotation databases

EnsembliENSMUST00000034941; ENSMUSP00000034941; ENSMUSG00000032377
GeneIDi235527
KEGGimmu:235527
UCSCiuc009ras.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035919 mRNA Translation: BAC29242.1
AK082330 mRNA Translation: BAC38468.1
AK141580 mRNA Translation: BAE24748.1
AK165919 mRNA Translation: BAE38460.1
BC052067 mRNA Translation: AAH52067.1
CCDSiCCDS23407.1
RefSeqiNP_848826.1, NM_178711.3
UniGeneiMm.55289

3D structure databases

ProteinModelPortaliP58196
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034941

PTM databases

PhosphoSitePlusiP58196
SwissPalmiP58196

Proteomic databases

MaxQBiP58196
PaxDbiP58196
PeptideAtlasiP58196
PRIDEiP58196

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034941; ENSMUSP00000034941; ENSMUSG00000032377
GeneIDi235527
KEGGimmu:235527
UCSCiuc009ras.1 mouse

Organism-specific databases

CTDi57088
MGIiMGI:2143267 Plscr4

Phylogenomic databases

eggNOGiKOG0621 Eukaryota
ENOG410XSYS LUCA
GeneTreeiENSGT00390000002884
HOGENOMiHOG000237356
HOVERGENiHBG019157
InParanoidiP58196
OMAiDQMVYIV
OrthoDBiEOG091G0CUL
PhylomeDBiP58196
TreeFamiTF314939

Enzyme and pathway databases

BRENDAi3.6.99.B1 3474

Miscellaneous databases

PROiPR:P58196
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032377 Expressed in 162 organ(s), highest expression level in brain blood vessel
CleanExiMM_PLSCR4
GenevisibleiP58196 MM

Family and domain databases

InterProiView protein in InterPro
IPR005552 Scramblase
PANTHERiPTHR23248 PTHR23248, 1 hit
PfamiView protein in Pfam
PF03803 Scramblase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLS4_MOUSE
AccessioniPrimary (citable) accession number: P58196
Secondary accession number(s): Q3TMI2, Q8BH62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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