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UniProtKB - P58196 (PLS4_MOUSE)
Protein
Phospholipid scramblase 4
Gene
Plscr4
Organism
Mus musculus (Mouse)
Status
Functioni
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Cofactori
GO - Molecular functioni
- CD4 receptor binding Source: MGI
- enzyme binding Source: MGI
- phospholipid scramblase activity Source: GO_Central
GO - Biological processi
- cellular response to lipopolysaccharide Source: UniProtKB
- plasma membrane phospholipid scrambling Source: GO_Central
Keywordsi
Ligand | Calcium |
Enzyme and pathway databases
BRENDAi | 7.6.2.1, 3474 |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipid scramblase 4Short name: PL scramblase 4 Alternative name(s): Ca(2+)-dependent phospholipid scramblase 4 |
Gene namesi | Name:Plscr4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2143267, Plscr4 |
VEuPathDBi | HostDB:ENSMUSG00000032377 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type II membrane protein By similarity
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 299 | CytoplasmicBy similarityAdd BLAST | 299 | |
Transmembranei | 300 – 316 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 317 – 326 | ExtracellularBy similarity | 10 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000100793 | 1 – 326 | Phospholipid scramblase 4Add BLAST | 326 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 79 | Phosphotyrosine; by ABLBy similarity | 1 | |
Modified residuei | 84 | Phosphotyrosine; by ABLBy similarity | 1 | |
Lipidationi | 193 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 194 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 195 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 197 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 198 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
MaxQBi | P58196 |
PaxDbi | P58196 |
PeptideAtlasi | P58196 |
PRIDEi | P58196 |
ProteomicsDBi | 289626 |
PTM databases
PhosphoSitePlusi | P58196 |
SwissPalmi | P58196 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032377, Expressed in brain blood vessel and 191 other tissues |
Genevisiblei | P58196, MM |
Interactioni
Subunit structurei
Interacts with PDCD6.
By similarityGO - Molecular functioni
- CD4 receptor binding Source: MGI
- enzyme binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034941 |
Miscellaneous databases
RNActi | P58196, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 94 | Proline-rich domain (PRD)By similarityAdd BLAST | 94 | |
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 18 – 25 | SH3-binding 1Sequence analysis | 8 | |
Motifi | 30 – 33 | PPxY motifSequence analysis | 4 | |
Motifi | 41 – 49 | SH3-binding 2Sequence analysis | 9 | |
Motifi | 94 – 102 | SH3-binding 3Sequence analysis | 9 |
Domaini
The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.By similarity
Sequence similaritiesi
Belongs to the phospholipid scramblase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0621, Eukaryota |
GeneTreei | ENSGT00940000161947 |
HOGENOMi | CLU_053024_0_0_1 |
InParanoidi | P58196 |
OMAi | GTHPIQY |
OrthoDBi | 1015148at2759 |
PhylomeDBi | P58196 |
TreeFami | TF314939 |
Family and domain databases
InterProi | View protein in InterPro IPR005552, Scramblase |
PANTHERi | PTHR23248, PTHR23248, 1 hit |
Pfami | View protein in Pfam PF03803, Scramblase, 1 hit |
i Sequence
Sequence statusi: Complete.
P58196-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGLVPTAPE QPTEEMENQI KSPTAVPDAP PDYNSHFAPG PAGPVASPSA
60 70 80 90 100
GLPMGYYIPQ QPGAIPLYHP TGGTHPIQYQ PGKYPVTNQP APIMWMAGPA
110 120 130 140 150
PVPNCPPGLE YLAQLDNIHV LQHVEPLELM TRFETNNRYD IKNNIDQMVY
160 170 180 190 200
IVTEDTDDFT RNAYRNLRPF VLRVTDCLGR EIMTMQRPFR CTCCCFCCPC
210 220 230 240 250
ARQELEVQCP PGVTIGFVAE HWNLCRASYS IQNEKKESMM RVRGPCATYG
260 270 280 290 300
CGSDSVFEIN SLDGVSNIGS IIRKWNGFLS TMVNADHFEI RFPLALDVKM
310 320
KAMIFGSCFL IDFMYFERPP PRRMSR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK035919 mRNA Translation: BAC29242.1 AK082330 mRNA Translation: BAC38468.1 AK141580 mRNA Translation: BAE24748.1 AK165919 mRNA Translation: BAE38460.1 BC052067 mRNA Translation: AAH52067.1 |
CCDSi | CCDS23407.1 |
RefSeqi | NP_848826.1, NM_178711.3 |
Genome annotation databases
Ensembli | ENSMUST00000034941; ENSMUSP00000034941; ENSMUSG00000032377 |
GeneIDi | 235527 |
KEGGi | mmu:235527 |
UCSCi | uc009ras.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK035919 mRNA Translation: BAC29242.1 AK082330 mRNA Translation: BAC38468.1 AK141580 mRNA Translation: BAE24748.1 AK165919 mRNA Translation: BAE38460.1 BC052067 mRNA Translation: AAH52067.1 |
CCDSi | CCDS23407.1 |
RefSeqi | NP_848826.1, NM_178711.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034941 |
PTM databases
PhosphoSitePlusi | P58196 |
SwissPalmi | P58196 |
Proteomic databases
MaxQBi | P58196 |
PaxDbi | P58196 |
PeptideAtlasi | P58196 |
PRIDEi | P58196 |
ProteomicsDBi | 289626 |
Protocols and materials databases
Antibodypediai | 948, 130 antibodies from 26 providers |
DNASUi | 235527 |
Genome annotation databases
Ensembli | ENSMUST00000034941; ENSMUSP00000034941; ENSMUSG00000032377 |
GeneIDi | 235527 |
KEGGi | mmu:235527 |
UCSCi | uc009ras.1, mouse |
Organism-specific databases
CTDi | 57088 |
MGIi | MGI:2143267, Plscr4 |
VEuPathDBi | HostDB:ENSMUSG00000032377 |
Phylogenomic databases
eggNOGi | KOG0621, Eukaryota |
GeneTreei | ENSGT00940000161947 |
HOGENOMi | CLU_053024_0_0_1 |
InParanoidi | P58196 |
OMAi | GTHPIQY |
OrthoDBi | 1015148at2759 |
PhylomeDBi | P58196 |
TreeFami | TF314939 |
Enzyme and pathway databases
BRENDAi | 7.6.2.1, 3474 |
Miscellaneous databases
BioGRID-ORCSi | 235527, 2 hits in 67 CRISPR screens |
PROi | PR:P58196 |
RNActi | P58196, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032377, Expressed in brain blood vessel and 191 other tissues |
Genevisiblei | P58196, MM |
Family and domain databases
InterProi | View protein in InterPro IPR005552, Scramblase |
PANTHERi | PTHR23248, PTHR23248, 1 hit |
Pfami | View protein in Pfam PF03803, Scramblase, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLS4_MOUSE | |
Accessioni | P58196Primary (citable) accession number: P58196 Secondary accession number(s): Q3TMI2, Q8BH62 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | July 19, 2005 | |
Last modified: | February 23, 2022 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families