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Protein

Phospholipid scramblase 1

Gene

Plscr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation (By similarity).By similarity

Cofactori

Ca2+By similarity

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • defense response to virus Source: UniProtKB
  • immune response Source: RGD
  • negative regulation of viral genome replication Source: UniProtKB
  • phosphatidylserine exposure on apoptotic cell surface Source: GO_Central
  • phospholipid scrambling Source: UniProtKB
  • phospholipid transport Source: RGD
  • positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity Source: UniProtKB
  • positive regulation of innate immune response Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • regulation of Fc receptor mediated stimulatory signaling pathway Source: UniProtKB
  • regulation of mast cell activation Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processAntiviral defense
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid scramblase 1
Short name:
PL scramblase 1
Alternative name(s):
Ca(2+)-dependent phospholipid scramblase 1
Gene namesi
Name:Plscr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620521 Plscr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 305CytoplasmicSequence analysisAdd BLAST305
Transmembranei306 – 322HelicalSequence analysisAdd BLAST17
Topological domaini323 – 335ExtracellularSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007861 – 335Phospholipid scramblase 1Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91Phosphotyrosine; by ABLBy similarity1
Modified residuei178Phosphothreonine; by PKCBy similarity1
Lipidationi201S-palmitoyl cysteineBy similarity1
Lipidationi202S-palmitoyl cysteineBy similarity1
Lipidationi205S-palmitoyl cysteineBy similarity1
Lipidationi206S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP58195
PRIDEiP58195

Expressioni

Gene expression databases

BgeeiENSRNOG00000008048
ExpressionAtlasiP58195 baseline and differential
GenevisibleiP58195 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053569

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 2917
Repeati30 – 3627
Repeati37 – 4337
Repeati44 – 5047
Repeati51 – 5757
Repeati58 – 6467
Repeati65 – 717; approximate7

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 101Proline-rich domain (PRD)By similarityAdd BLAST101
Regioni23 – 717 X 7 AA tandem repeats of Q-G-P-Y-[AP]-G-PAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 72SH3-binding 1Sequence analysis9
Motifi101 – 109SH3-binding 2Sequence analysis9
Motifi274 – 283Nuclear localization signalBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi106 – 109Poly-Pro4
Compositional biasi198 – 206Cys-rich9

Domaini

The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.By similarity

Sequence similaritiesi

Belongs to the phospholipid scramblase family.Curated

Keywords - Domaini

Repeat, SH3-binding, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0621 Eukaryota
ENOG410XSYS LUCA
GeneTreeiENSGT00390000002884
HOGENOMiHOG000237356
HOVERGENiHBG019157
InParanoidiP58195

Family and domain databases

InterProiView protein in InterPro
IPR005552 Scramblase
PANTHERiPTHR23248 PTHR23248, 1 hit
PfamiView protein in Pfam
PF03803 Scramblase, 1 hit

Sequencei

Sequence statusi: Complete.

P58195-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKHGPPEHA AYPIPQADYQ GSQGPYPGPQ GPYPGPQGPY AGPQGPYPGP
60 70 80 90 100
QGPYAGPQGP YPGPQPGYPV PPGSYAGGDP SGFPVQHQPA YNHPGGPGGT
110 120 130 140 150
PWMQAPPPPL DCPPGLEYLT QIDQILVHQQ IELLEVLTGF ETNNKYEIKN
160 170 180 190 200
SLGQRVYFAV EDTDCCTRNC CGASRPFTLR ILDNMGREVM TLERPLRCSS
210 220 230 240 250
CCFPCCLQEI EIQAPPGVPV GYVIQTWHPC LPKFTLQNEK RQDVLKVVGP
260 270 280 290 300
CVVCSCCSDI DFELKSLDEE SVVGKISKQW SGFVREAFTD ADNFGIQFPL
310 320 330
DLDVKMKAVM LGACFLIDFM FFERTGNEEQ RSGVW
Length:335
Mass (Da):36,711
Last modified:June 20, 2001 - v1
Checksum:i7A674DDE7F2759EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY024347 mRNA Translation: AAK00575.1
RefSeqiNP_476542.1, NM_057194.1
XP_006243600.1, XM_006243538.3
UniGeneiRn.96807

Genome annotation databases

EnsembliENSRNOT00000010689; ENSRNOP00000010689; ENSRNOG00000008048
GeneIDi117540
KEGGirno:117540
UCSCiRGD:620521 rat

Similar proteinsi

Entry informationi

Entry nameiPLS1_RAT
AccessioniPrimary (citable) accession number: P58195
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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