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Protein

Olfactory receptor 12D2

Gene

OR12D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 12D2
Alternative name(s):
Hs6M1-20
Olfactory receptor OR6-28
Gene namesi
Name:OR12D2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000168787.6
HostDB:ENSG00000280236.1
HGNCiHGNC:8178 OR12D2
neXtProtiNX_P58182

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 215Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini216 – 236CytoplasmicSequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 307CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26529
OpenTargetsiENSG00000280236
PharmGKBiPA32028

Polymorphism and mutation databases

BioMutaiOR12D2
DMDMi288558820

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507281 – 307Olfactory receptor 12D2Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58182
PeptideAtlasiP58182
PRIDEiP58182
ProteomicsDBi57055

PTM databases

iPTMnetiP58182
PhosphoSitePlusiP58182

Expressioni

Gene expression databases

BgeeiENSG00000168787 Expressed in 2 organ(s), highest expression level in Ammon's horn
CleanExiHS_OR12D2
ExpressionAtlasiP58182 baseline and differential
GenevisibleiP58182 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000373047

Structurei

3D structure databases

ProteinModelPortaliP58182
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH3D Eukaryota
ENOG410YBP5 LUCA
GeneTreeiENSGT00390000018942
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiP58182
KOiK04257
OMAiMAITIWV
OrthoDBiEOG09370DTX
PhylomeDBiP58182
TreeFamiTF338273

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P58182-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNTTSVTEF LLLGVTDIQE LQPFLFVVFL TIYFISVTGN GAVLMIVISD
60 70 80 90 100
PRLHSLMYFF LGNLSYLDIC YSTVTLPKML QNFLSTHKAI SFLGCISQLH
110 120 130 140 150
FFHSLGSTES MLFAVMAFDL SVAICKPLRY TVIMNPQLCT QMAITIWVIG
160 170 180 190 200
FFHALLHSVM TSRLNFCGSN RIHHFLCDIK PLLKLACGNT ELNQWLLSTV
210 220 230 240 250
TGTIAMGPFF LTLLSYFYII TYLFFKTRSC SMLCKALSTC ASHFMVVILF
260 270 280 290 300
YAPVLFTYIH PALESFMDQD RIVAIMYTVV TPVLNPLIYT LRNKEVKGAL

GRVIRRL
Length:307
Mass (Da):34,813
Last modified:February 9, 2010 - v2
Checksum:i982907668FCFDE8A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140T9F1A0A140T9F1_HUMAN
Olfactory receptor
OR12D2
307Annotation score:
A0A140T931A0A140T931_HUMAN
Olfactory receptor
OR12D2
307Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05756947V → F. Corresponds to variant dbSNP:rs9257834Ensembl.1
Natural variantiVAR_05757056L → P. Corresponds to variant dbSNP:rs4987411Ensembl.1
Natural variantiVAR_058967104S → F4 PublicationsCorresponds to variant dbSNP:rs3128853Ensembl.1
Natural variantiVAR_057571113F → L. Corresponds to variant dbSNP:rs2073154Ensembl.1
Natural variantiVAR_057572120L → R. Corresponds to variant dbSNP:rs2073153Ensembl.1
Natural variantiVAR_057573121S → C. Corresponds to variant dbSNP:rs2073152Ensembl.1
Natural variantiVAR_057574132V → G. Corresponds to variant dbSNP:rs11752608Ensembl.1
Natural variantiVAR_057575159V → I. Corresponds to variant dbSNP:rs2073151Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004171 Genomic DNA No translation available.
AL035542 Genomic DNA Translation: CAB44510.1
AL645927 Genomic DNA No translation available.
AL662869 Genomic DNA No translation available.
CR759808 Genomic DNA No translation available.
BX927232 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03191.1
BC069123 mRNA Translation: AAH69123.1
BC101742 mRNA Translation: AAI01743.1
BC101746 mRNA Translation: AAI01747.1
BK004523 Genomic DNA Translation: DAA04921.1
RefSeqiNP_039224.2, NM_013936.3
UniGeneiHs.247862

Genome annotation databases

EnsembliENST00000377140; ENSP00000366345; ENSG00000204690
ENST00000414415; ENSP00000414137; ENSG00000233481
ENST00000438569; ENSP00000415065; ENSG00000235966
ENST00000623183; ENSP00000485112; ENSG00000280236
ENST00000642051; ENSP00000493463; ENSG00000280236
GeneIDi26529
KEGGihsa:26529
UCSCiuc003nmf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004171 Genomic DNA No translation available.
AL035542 Genomic DNA Translation: CAB44510.1
AL645927 Genomic DNA No translation available.
AL662869 Genomic DNA No translation available.
CR759808 Genomic DNA No translation available.
BX927232 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03191.1
BC069123 mRNA Translation: AAH69123.1
BC101742 mRNA Translation: AAI01743.1
BC101746 mRNA Translation: AAI01747.1
BK004523 Genomic DNA Translation: DAA04921.1
RefSeqiNP_039224.2, NM_013936.3
UniGeneiHs.247862

3D structure databases

ProteinModelPortaliP58182
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000373047

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP58182
PhosphoSitePlusiP58182

Polymorphism and mutation databases

BioMutaiOR12D2
DMDMi288558820

Proteomic databases

PaxDbiP58182
PeptideAtlasiP58182
PRIDEiP58182
ProteomicsDBi57055

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377140; ENSP00000366345; ENSG00000204690
ENST00000414415; ENSP00000414137; ENSG00000233481
ENST00000438569; ENSP00000415065; ENSG00000235966
ENST00000623183; ENSP00000485112; ENSG00000280236
ENST00000642051; ENSP00000493463; ENSG00000280236
GeneIDi26529
KEGGihsa:26529
UCSCiuc003nmf.4 human

Organism-specific databases

CTDi26529
DisGeNETi26529
EuPathDBiHostDB:ENSG00000168787.6
HostDB:ENSG00000280236.1
GeneCardsiOR12D2
H-InvDBiHIX0166173
HIX0166712
HIX0166973
HIX0167454
HIX0207641
HIX0207710
HIX0207764
HGNCiHGNC:8178 OR12D2
neXtProtiNX_P58182
OpenTargetsiENSG00000280236
PharmGKBiPA32028
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH3D Eukaryota
ENOG410YBP5 LUCA
GeneTreeiENSGT00390000018942
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiP58182
KOiK04257
OMAiMAITIWV
OrthoDBiEOG09370DTX
PhylomeDBiP58182
TreeFamiTF338273

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR12D2
GenomeRNAii26529
PROiPR:P58182

Gene expression databases

BgeeiENSG00000168787 Expressed in 2 organ(s), highest expression level in Ammon's horn
CleanExiHS_OR12D2
ExpressionAtlasiP58182 baseline and differential
GenevisibleiP58182 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO12D2_HUMAN
AccessioniPrimary (citable) accession number: P58182
Secondary accession number(s): B0S862, Q5SUN9, Q6IET9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: February 9, 2010
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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