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Protein

Olfactory receptor 10A3

Gene

OR10A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

  • sensory perception of smell Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A3
Alternative name(s):
HTPCRX12
Olfactory receptor OR11-97
Gene namesi
Name:OR10A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170683.5
HGNCiHGNC:8162 OR10A3
neXtProtiNX_P58181

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170683
PharmGKBiPA31951

Polymorphism and mutation databases

BioMutaiOR10A3
DMDMi14423787

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506851 – 314Olfactory receptor 10A3Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58181
PeptideAtlasiP58181
PRIDEiP58181
ProteomicsDBi57054

PTM databases

iPTMnetiP58181
PhosphoSitePlusiP58181

Expressioni

Gene expression databases

BgeeiENSG00000170683 Expressed in 5 organ(s), highest expression level in skin of leg
CleanExiHS_OR10A3
ExpressionAtlasiP58181 baseline and differential
GenevisibleiP58181 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353988

Structurei

3D structure databases

ProteinModelPortaliP58181
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK8 Eukaryota
ENOG410YDA3 LUCA
GeneTreeiENSGT00760000119002
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiP58181
KOiK04257
OMAiVMFSWIS
OrthoDBiEOG091G0FFM
PhylomeDBiP58181
TreeFamiTF337350

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P58181-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRQNQSCVV EFILLGFSNF PELQVQLFGV FLVIYVVTLM GNAIITVIIS
60 70 80 90 100
LNQSLHVPMY LFLLNLSVVE VSFSAVITPE MLVVLSTEKT MISFVGCFAQ
110 120 130 140 150
MYFILLFGGT ECFLLGAMAY DRFAAICHPL NYPVIMNRGV FMKLVIFSWI
160 170 180 190 200
SGIMVATVQT TWVFSFPFCG PNEINHLFCE TPPVLELVCA DTFLFEIYAF
210 220 230 240 250
TGTILIVMVP FLLILLSYIR VLFAILKMPS TTGRQKAFST CASHLTSVTL
260 270 280 290 300
FYGTANMTYL QPKSGYSPET KKLISLAYTL LTPLLNPLIY SLRNSEMKRT
310
LIKLWRRKVI LHTF
Length:314
Mass (Da):35,535
Last modified:June 20, 2001 - v1
Checksum:i3355B17F4AFBF647
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05326220F → V. Corresponds to variant dbSNP:rs16934214Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065768 Genomic DNA Translation: BAC05988.1
AC044810 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68641.1
BC137031 mRNA Translation: AAI37032.1
BC137032 mRNA Translation: AAI37033.1
AF399634 Genomic DNA Translation: AAK95119.1
X64986 mRNA No translation available.
BK004404 Genomic DNA Translation: DAA04802.1
CCDSiCCDS31421.1
RefSeqiNP_001003745.1, NM_001003745.1
UniGeneiHs.381322

Genome annotation databases

EnsembliENST00000360759; ENSP00000353988; ENSG00000170683
ENST00000612788; ENSP00000484096; ENSG00000273953
ENST00000626843; ENSP00000487530; ENSG00000281680
ENST00000641438; ENSP00000493029; ENSG00000281680
ENST00000642047; ENSP00000493303; ENSG00000170683
GeneIDi26496
KEGGihsa:26496
UCSCiuc010rbi.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065768 Genomic DNA Translation: BAC05988.1
AC044810 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68641.1
BC137031 mRNA Translation: AAI37032.1
BC137032 mRNA Translation: AAI37033.1
AF399634 Genomic DNA Translation: AAK95119.1
X64986 mRNA No translation available.
BK004404 Genomic DNA Translation: DAA04802.1
CCDSiCCDS31421.1
RefSeqiNP_001003745.1, NM_001003745.1
UniGeneiHs.381322

3D structure databases

ProteinModelPortaliP58181
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353988

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP58181
PhosphoSitePlusiP58181

Polymorphism and mutation databases

BioMutaiOR10A3
DMDMi14423787

Proteomic databases

PaxDbiP58181
PeptideAtlasiP58181
PRIDEiP58181
ProteomicsDBi57054

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360759; ENSP00000353988; ENSG00000170683
ENST00000612788; ENSP00000484096; ENSG00000273953
ENST00000626843; ENSP00000487530; ENSG00000281680
ENST00000641438; ENSP00000493029; ENSG00000281680
ENST00000642047; ENSP00000493303; ENSG00000170683
GeneIDi26496
KEGGihsa:26496
UCSCiuc010rbi.3 human

Organism-specific databases

CTDi26496
EuPathDBiHostDB:ENSG00000170683.5
GeneCardsiOR10A3
HGNCiHGNC:8162 OR10A3
neXtProtiNX_P58181
OpenTargetsiENSG00000170683
PharmGKBiPA31951
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKK8 Eukaryota
ENOG410YDA3 LUCA
GeneTreeiENSGT00760000119002
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiP58181
KOiK04257
OMAiVMFSWIS
OrthoDBiEOG091G0FFM
PhylomeDBiP58181
TreeFamiTF337350

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10A3
GenomeRNAii26496
PROiPR:P58181

Gene expression databases

BgeeiENSG00000170683 Expressed in 5 organ(s), highest expression level in skin of leg
CleanExiHS_OR10A3
ExpressionAtlasiP58181 baseline and differential
GenevisibleiP58181 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10A3_HUMAN
AccessioniPrimary (citable) accession number: P58181
Secondary accession number(s): B9EH39, Q6IF58, Q96R11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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